ChemInform Abstract: An Organo-NHC Catalyzed Domino Addition Approach for the Selective Synthesis of 5-Butynylisoxazoles (III) and Subsequent Sonogashira Coupling.

ChemInform ◽  
2016 ◽  
Vol 47 (6) ◽  
pp. no-no
Author(s):  
Shravankumar Kankala ◽  
Sreekantha B. Jonnalagadda ◽  
Chandra Sekhar Vasam
Keyword(s):  
Selective Synthesis ◽  
Sonogashira Coupling

An organo-NHC catalyzed domino addition approach for the selective synthesis of 5-butynylisoxazoles and subsequent Sonogashira coupling

RSC Advances ◽  
2015 ◽  
Vol 5 (93) ◽  
pp. 76582-76587 ◽  
Author(s):  
Shravankumar Kankala ◽  
Sreekantha B. Jonnalagadda ◽  
Chandra Sekhar Vasam
Keyword(s):  
Cross Coupling ◽  
Selective Synthesis ◽  
Sonogashira Coupling ◽  
Internal Alkynes

An organo-NHC catalysed domino addition approach for the selective synthesis of 5-butynylisoxazoles and the subsequent Sonogashira cross-coupling for the selective synthesis of corresponding internal alkynes is described.

Palladium-Catalyzed One-Pot Consecutive Amination and Sonogashira Coupling for Selective Synthesis of 2-Alkynylanilines

2015 ◽  
Vol 357 (14-15) ◽  
pp. 3052-3056 ◽  
Author(s):  
Shanfei Pan ◽  
Xueji Ma ◽  
Danni Zhong ◽  
Wanzhi Chen ◽  
Miaochang Liu ◽  
...  
Keyword(s):  
Selective Synthesis ◽  
Sonogashira Coupling ◽  
One Pot ◽  
Palladium Catalyzed

ChemInform Abstract: Palladium-Catalyzed One-Pot Consecutive Amination and Sonogashira Coupling for Selective Synthesis of 2-Alkynylanilines.

ChemInform ◽  
2016 ◽  
Vol 47 (8) ◽  
pp. no-no
Author(s):  
Shanfei Pan ◽  
Xueji Ma ◽  
Danni Zhong ◽  
Wanzhi Chen ◽  
Miaochang Liu ◽  
...  
Keyword(s):  
Selective Synthesis ◽  
Sonogashira Coupling ◽  
One Pot ◽  
Palladium Catalyzed

RetroBioCat: Computer-Aided Synthesis Planning for Biocatalytic Reactions and Cascades

2020 ◽  
Author(s):  
William Finnigan ◽  
Lorna J. Hepworth ◽  
Nicholas J. Turner ◽  
Sabine Flitsch
Keyword(s):  
Organic Chemistry ◽  
Computer Aided Design ◽  
Selective Synthesis ◽  
Test Set ◽  
Synthesis Design ◽  
Computer Aided ◽  
Synthesis Planning ◽  
Enzymatic Cascades ◽  
Target Molecules ◽  
Aided Design

As the enzyme toolbox for biocatalysis has expanded, so has the potential for the construction of powerful enzymatic cascades for efficient and selective synthesis of target molecules. Additionally, recent advances in computer-aided synthesis planning (CASP) are revolutionizing synthesis design in both synthetic biology and organic chemistry. However, the potential for biocatalysis is not well captured by tools currently available in either field. Here we present RetroBioCat, an intuitive and accessible tool for computer-aided design of biocatalytic cascades, freely available at retrobiocat.com. Our approach uses a set of expertly encoded reaction rules encompassing the enzyme toolbox for biocatalysis, and a system for identifying literature precedent for enzymes with the correct substrate specificity where this is available. Applying these rules for automated biocatalytic retrosynthesis, we show our tool to be capable of identifying promising biocatalytic pathways to target molecules, validated using a test-set of recent cascades described in the literature.

Enantioselective Synthesis of Azamerone

2018 ◽  
Author(s):  
Matthew L. Landry ◽  
Grace McKenna ◽  
Noah Burns
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Selective Synthesis

A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.

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