ChemInform Abstract: Iodine Catalyzed One-Pot Synthesis of Highly Substituted N-Methyl Pyrroles via [3 + 2] Annulation and Their in vitro Evaluation as Antibacterial Agents.

ChemInform ◽  
2015 ◽  
Vol 46 (49) ◽  
pp. no-no
Author(s):  
Biguvu Balachandra ◽  
Sivakumar Shanmugam ◽  
Thillaichidambaram Muneeswaran ◽  
Muthiah Ramakritinan
Keyword(s):  
Antibacterial Agents ◽  
One Pot ◽  
In Vitro Evaluation ◽  
One Pot Synthesis

Iodine catalyzed one-pot synthesis of highly substituted N-methyl pyrroles via [3 + 2] annulation and their in vitro evaluation as antibacterial agents

RSC Advances ◽  
2015 ◽  
Vol 5 (79) ◽  
pp. 64781-64789 ◽  
Author(s):  
Biguvu Balachandra ◽  
Sivakumar Shanmugam ◽  
Thillaichidambaram Muneeswaran ◽  
Muthiah Ramakritinan
Keyword(s):  
Efficient Method ◽  
Antibacterial Agents ◽  
Environmentally Friendly ◽  
One Pot ◽  
In Vitro Evaluation ◽  
New Class ◽  
One Pot Synthesis ◽  
Substituted Pyrroles

A new class of highly substituted pyrroles have been synthesized via a simple, fast, and efficient method using environmentally friendly iodine catalyzed [3 + 2] annulation.

New Di(heteroaryl)ethenes as Apoptotic Anti‐proliferative Agents Towards Breast Cancer: Design, One‐Pot Synthesis and In Vitro Evaluation

2020 ◽  
Vol 5 (8) ◽  
pp. 2581-2587
Author(s):  
Carmela Bonaccorso ◽  
Irina Naletova ◽  
Cristina Satriano ◽  
Giorgia Spampinato ◽  
Vincenza Barresi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
One Pot ◽  
In Vitro Evaluation ◽  
One Pot Synthesis

One-pot synthesis of chelator-free 89Zr-incorporated hierarchical hematite nanoclusters for in vitro evaluation

2019 ◽  
Vol 21 (11) ◽  
Author(s):  
Pyeong Seok Choi ◽  
Jun Young Lee ◽  
Chirag K. Vyas ◽  
Seung Dae Yang ◽  
Sang Wook Kim ◽  
...  
Keyword(s):  
One Pot ◽  
In Vitro Evaluation ◽  
One Pot Synthesis

scholarly journals One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4152
Author(s):  
Jessica Bais ◽  
Fabio Benedetti ◽  
Federico Berti ◽  
Iole Cerminara ◽  
Sara Drioli ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Biginelli Reaction ◽  
Guanidine Hydrochloride ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
One Pot Synthesis ◽  
Bace 1

A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea. Selected 2-thiooxo and 2-imino analogs were also obtained with the Biginelli reaction from thiourea and guanidine hydrochloride, respectively. The products were screened in vitro for their β-secretase inhibitory activity. The majority of the compounds resulted to be active, with IC50 in the range 100 nM–50 μM.

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