ChemInform Abstract: Pd-Mediated Multicomponent Synthesis of Highly Functionalized Pyridines and Consequential C-C Coupling Using Suzuki Reaction in One Pot: Their in vitro Evaluation as Potential Antibacterial Agents.

ChemInform ◽  
2015 ◽  
Vol 46 (9) ◽  
pp. no-no
Author(s):  
L. Srinivasula Reddy ◽  
T. Ram Reddy ◽  
N. C. Gangi Reddy ◽  
Reddy Bodireddy Mohan ◽  
Y. Lingappa
Keyword(s):  
Antibacterial Agents ◽  
Suzuki Reaction ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
In Vitro Evaluation

ChemInform Abstract: Iodine Catalyzed One-Pot Synthesis of Highly Substituted N-Methyl Pyrroles via [3 + 2] Annulation and Their in vitro Evaluation as Antibacterial Agents.

ChemInform ◽  
2015 ◽  
Vol 46 (49) ◽  
pp. no-no
Author(s):  
Biguvu Balachandra ◽  
Sivakumar Shanmugam ◽  
Thillaichidambaram Muneeswaran ◽  
Muthiah Ramakritinan
Keyword(s):  
Antibacterial Agents ◽  
One Pot ◽  
In Vitro Evaluation ◽  
One Pot Synthesis

Iodine catalyzed one-pot synthesis of highly substituted N-methyl pyrroles via [3 + 2] annulation and their in vitro evaluation as antibacterial agents

RSC Advances ◽  
2015 ◽  
Vol 5 (79) ◽  
pp. 64781-64789 ◽  
Author(s):  
Biguvu Balachandra ◽  
Sivakumar Shanmugam ◽  
Thillaichidambaram Muneeswaran ◽  
Muthiah Ramakritinan
Keyword(s):  
Efficient Method ◽  
Antibacterial Agents ◽  
Environmentally Friendly ◽  
One Pot ◽  
In Vitro Evaluation ◽  
New Class ◽  
One Pot Synthesis ◽  
Substituted Pyrroles

A new class of highly substituted pyrroles have been synthesized via a simple, fast, and efficient method using environmentally friendly iodine catalyzed [3 + 2] annulation.

New Di(heteroaryl)ethenes as Apoptotic Anti‐proliferative Agents Towards Breast Cancer: Design, One‐Pot Synthesis and In Vitro Evaluation

2020 ◽  
Vol 5 (8) ◽  
pp. 2581-2587
Author(s):  
Carmela Bonaccorso ◽  
Irina Naletova ◽  
Cristina Satriano ◽  
Giorgia Spampinato ◽  
Vincenza Barresi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
One Pot ◽  
In Vitro Evaluation ◽  
One Pot Synthesis

In vitro evaluation of caries inhibition promoted by self-etching adhesive systems containing antibacterial agents

2005 ◽  
Vol 75B (1) ◽  
pp. 122-127 ◽  
Author(s):  
Maristela M. Lobo ◽  
Reginaldo B. Gonçalves ◽  
Luiz André F. Pimenta ◽  
Ana Karina B. Bedran-Russo ◽  
Patrícia N. R. Pereira
Keyword(s):  
Antibacterial Agents ◽  
Adhesive Systems ◽  
In Vitro Evaluation

Ultrasound Assisted One-pot and Sequential Synthesis of 3-methyleneisoindolin- 1-ones and their in vitro Evaluation

2018 ◽  
Vol 18 (17) ◽  
pp. 1498-1505
Author(s):  
Kancharla Suman ◽  
Yarlagadda Bharath ◽  
V. Anuradha ◽  
Mandava V. Basaveswara Rao ◽  
Manojit Pal
Keyword(s):  
One Pot ◽  
In Vitro Evaluation ◽  
Ultrasound Assisted

scholarly journals Eco-Friendly Synthesis, Biological Evaluation, and In Silico Molecular Docking Approach of Some New Quinoline Derivatives as Potential Antioxidant and Antibacterial Agents

2021 ◽  
Vol 9 ◽  
Author(s):  
Ahmed M. El-Saghier ◽  
Mohamed El-Naggar ◽  
Abdel Haleem M. Hussein ◽  
Abu-Bakr A. El-Adasy ◽  
M. Olish ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Molecular Docking ◽  
In Silico ◽  
Antibacterial Agents ◽  
Dna Gyrase ◽  
Biological Evaluation ◽  
Quinoline Derivatives ◽  
One Pot ◽  
Solvent Free Conditions

A new series of quinoline derivatives 5–12 were efficiently synthesized via one-pot multicomponent reaction (MCR) of resorcinol, aromatic aldehydes, β-ketoesters, and aliphatic/aromatic amines under solvent-free conditions. All products were obtained in excellent yields, pure at low-cost processing, and short time. The structures of all compounds were characterized by means of spectral and elemental analyses. In addition, all the synthesized compounds 5–12 were in vitro screened for their antioxidant and antibacterial activity. Moreover, in silico molecular docking studies of the new quinoline derivatives with the target enzymes, human NAD (P)H dehydrogenase (quinone 1) and DNA gyrase, were achieved to endorse their binding affinities and to understand ligand–enzyme possible intermolecular interactions. Compound 9 displayed promising antioxidant and antibacterial activity, as well as it was found to have the highest negative binding energy of -9.1 and -9.3 kcal/mol for human NAD (P)H dehydrogenase (quinone 1) and DNA gyrase, respectively. Further, it complied with the Lipinski’s rule of five, Veber, and Ghose. Therefore, the quinoline analogue 9 could be promising chemical scaffold for the development of future drug candidates as antioxidant and antibacterial agents.

Microwave-Assisted One Pot Three-Component Synthesis of Novel Bioactive Thiazolyl-pyridazinediones As Potential Antimicrobial Agents against Antibiotic-Resistant Bacteria

2020 ◽  
Author(s):  
Saraa Abu-Melha ◽  
Sobhi Gomha ◽  
Amr Abouzid ◽  
Mastoura Edrees ◽  
Ahmed Abo Dena ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Biological Activities ◽  
Docking Studies ◽  
Resistant Bacteria ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Antibiotic Resistant ◽  
Naturally Occurring ◽  
High Efficient

Abstract Novel 2-thiazolyl-pyridazinedione derivatives were prepared via multicomponent synthesis under microwave irradiation as ecofriendly energy source and using the eco-friendly naturally occurring chitosan basic catalyst with high/efficient yields and short reaction time. All the prepared compounds were fully characterized by spectroscopic methods, and their in-vitro biological activities were investigated. The obtained results were compared with those of standard antibacterial/antifungal agents. DFT calculations and molecular docking studies were used to investigate the electronic properties and molecular interactions with specific microbial receptors.

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