ChemInform Abstract: Recent Advances in the Development of Synthetic Chemical Probes for Glycosidase Enzymes

ChemInform ◽  
2015 ◽  
Vol 46 (33) ◽  
pp. no-no
Author(s):  
Helen M. Burke ◽  
Thorfinnur Gunnlaugsson ◽  
Eoin M. Scanlan
Keyword(s):  
Chemical Probes ◽  
Recent Advances

scholarly journals Recent Advances in Chemical Biology of Mitochondria Targeting

2021 ◽  
Vol 9 ◽  
Author(s):  
Haiwei Wang ◽  
Bin Fang ◽  
Bo Peng ◽  
Limin Wang ◽  
Yufei Xue ◽  
...  
Keyword(s):  
Cell Function ◽  
Cell Metabolism ◽  
Mitochondrial Activity ◽  
Biological Applications ◽  
Chemical Probes ◽  
Recent Advances ◽  
Selective Targeting ◽  
Pros And Cons ◽  
Mitochondria Targeting ◽  
Time Acquisition

Mitochondria are vital subcellular organelles that generate most cellular chemical energy, regulate cell metabolism and maintain cell function. Mitochondrial dysfunction is directly linked to numerous diseases including neurodegenerative disorders, diabetes, thyroid squamous disease, cancer and septicemia. Thus, the design of specific mitochondria-targeting molecules and the realization of real-time acquisition of mitochondrial activity are powerful tools in the study and treatment of mitochondria dysfunction in related diseases. Recent advances in mitochondria-targeting agents have led to several important mitochondria chemical probes that offer the opportunity for selective targeting molecules, novel biological applications and therapeutic strategies. This review details the structural and physiological functional characteristics of mitochondria, and comprehensively summarizes and classifies mitochondria-targeting agents. In addition, their pros and cons and their related chemical biological applications are discussed. Finally, the potential biomedical applications of these agents are briefly prospected.

scholarly journals Recent advances in the development of synthetic chemical probes for glycosidase enzymes

2015 ◽  
Vol 51 (53) ◽  
pp. 10576-10588 ◽  
Author(s):  
Helen M. Burke ◽  
Thorfinnur Gunnlaugsson ◽  
Eoin M. Scanlan
Keyword(s):  
Chemical Probes ◽  
Recent Advances

A review of synthetic glycoconjugates as chemical probes for the detection of glycosidase enzymes and recent applications.

Recent advances in target identification by natural product based chemical probes

2016 ◽  
Vol 59 (9) ◽  
pp. 1088-1092 ◽  
Author(s):  
Benke Hong ◽  
Ting Dong ◽  
Xiaoguang Lei
Keyword(s):  
Natural Product ◽  
Target Identification ◽  
Chemical Probes ◽  
Recent Advances

scholarly journals Recent Advances in Chemical Biology Using Benzophenones and Diazirines as Radical Precursors

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2285 ◽  
Author(s):  
Muhammad Murtaza Hassan ◽  
Olasunkanmi O. Olaoye
Keyword(s):  
Chemical Biology ◽  
Biological Interactions ◽  
Chemical Probes ◽  
Cellular Mechanisms ◽  
Recent Advances ◽  
Acid Protein ◽  
Protein Nucleic Acid ◽  
The 1960S ◽  
Factor Interactions ◽  
Insight Into

The use of light-activated chemical probes to study biological interactions was first discovered in the 1960s, and has since found many applications in studying diseases and gaining deeper insight into various cellular mechanisms involving protein–protein, protein–nucleic acid, protein–ligand (drug, probe), and protein–co-factor interactions, among others. This technique, often referred to as photoaffinity labelling, uses radical precursors that react almost instantaneously to yield spatial and temporal information about the nature of the interaction and the interacting partner(s). This review focuses on the recent advances in chemical biology in the use of benzophenones and diazirines, two of the most commonly known light-activatable radical precursors, with a focus on the last three years, and is intended to provide a solid understanding of their chemical and biological principles and their applications.

Recent Advances in High Dispersion Spectroscopy of Globular Cluster Stars

1988 ◽  
Vol 132 ◽  
pp. 525-530
Author(s):  
Raffaele G. Gratton
Keyword(s):  
Globular Cluster ◽  
Globular Clusters ◽  
High Dispersion ◽  
Photographic Material ◽  
Recent Advances ◽  
Metal Abundances ◽  
Ccd Detectors ◽  
Major Progress

The use CCD detectors has allowed a major progress in abundance derivations for globular cluster stars in the last years. Abundances deduced from high dispersion spectra now correlates well with other abundance indicators. I discuss some problems concerning the derivation of accurate metal abundances for globular clusters using high dispersion spectra from both the old photographic and the most recent CCD data. The discrepant low abundances found by Cohen (1980), from photographic material for M71 giants, are found to be due to the use of too high microturbulences.

Chelation-assisted transition metal-catalysed C–H chalcogenylations

2020 ◽  
Vol 7 (8) ◽  
pp. 1022-1060 ◽  
Author(s):  
Wenbo Ma ◽  
Nikolaos Kaplaneris ◽  
Xinyue Fang ◽  
Linghui Gu ◽  
Ruhuai Mei ◽  
...  
Keyword(s):  
Transition Metal ◽  
Recent Advances ◽  
Site Selectivity ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This review summarizes recent advances in C–S and C–Se formations via transition metal-catalyzed C–H functionalization utilizing directing groups to control the site-selectivity.

Nucleosome dynamics

2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  
Keyword(s):  
High Resolution ◽  
Chromatin Structure ◽  
Current Knowledge ◽  
Dynamic Properties ◽  
Structure And Dynamics ◽  
Nucleosome Dynamics ◽  
Sharp Focus ◽  
Recent Advances ◽  
Insight Into ◽  
Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

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