ChemInform Abstract: Oleanolic Acid Synthetic Oligoglycosides: A Review on Recent Progress in Biological Activities

ChemInform ◽  
2014 ◽  
Vol 45 (39) ◽  
pp. no-no ◽  
Author(s):  
Kuo Xu ◽  
Fuhao Chu ◽  
Guoliang Li ◽  
Xin Xu ◽  
Penglong Wang ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Recent Progress ◽  
Biological Activities

Recent Progress in Oleanolic Acid: Structural Modification and Biological Activity

2021 ◽  
Vol 21 ◽  
Author(s):  
Wang Wang ◽  
Yutong Li ◽  
Yan Li ◽  
Dejuan Sun ◽  
Hua Li ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Structural Modification ◽  
Recent Progress ◽  
Biological Activities ◽  
Biological Effects ◽  
Biologically Active ◽  
In Vivo Models ◽  
Action Mechanisms

: Natural products have been proven as the main source of biologically active compounds, which are potentially useful for drug development. As one of the most studied pentacyclic triterpenes, oleanolic acid (OA) exhibits a broad range of biological activities and serves as a good scaffold for the development of novel derivatives that could be vital in drug discovery for various ailments. Up to now, many of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes the recent reports of OA derivatives (2016-present) and their biological effects and action mechanisms in vitro and in vivo models, and discusses the design of novel and potent derivatives.

ChemInform Abstract: Recent Progress in Biological Activities of Synthesized Phenothiazines

ChemInform ◽  
2011 ◽  
Vol 42 (42) ◽  
pp. no-no
Author(s):  
Krystian Pluta ◽  
Beata Morak-Mlodawska ◽  
Malgorzata Jelen
Keyword(s):  
Recent Progress ◽  
Biological Activities

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives

2014 ◽  
Vol 12 (28) ◽  
pp. 5192-5200 ◽  
Author(s):  
Liangfeng Fu ◽  
Qi-Xian Lin ◽  
Karen T. Liby ◽  
Michael B. Sporn ◽  
Gordon W. Gribble
Keyword(s):  
Methyl Ester ◽  
Oleanolic Acid ◽  
Biological Activities ◽  
Efficient Synthesis

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester).

scholarly journals Synthesis and antitumor activity of fluorouracil – oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates

MedChemComm ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 1370-1378 ◽  
Author(s):  
Chun-Mei Liu ◽  
Jia-Yan Huang ◽  
Li-Xin Sheng ◽  
Xiao-An Wen ◽  
Ke-Guang Cheng
Keyword(s):  
Antitumor Activity ◽  
Adverse Effects ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Biological Activities ◽  
Glycyrrhetinic Acid ◽  
Antitumor Activities ◽  
Pentacyclic Triterpene ◽  
Pentacyclic Triterpenes

Due to the obvious adverse effects of 5-fluorouracil and considering the diverse biological activities of pentacyclic triterpenes, twelve pentacyclic triterpene-5-fluorouracil conjugates were synthesized and their antitumor activities were evaluated.

scholarly journals A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1888 ◽  
Author(s):  
Wenhua Chen ◽  
Huiying Tan ◽  
Qian Liu ◽  
Xiaohua Zheng ◽  
Hua Zhang ◽  
...  
Keyword(s):  
Recent Progress ◽  
Therapeutic Agent ◽  
Biological Activities ◽  
Review Article ◽  
Phellinus Linteus ◽  
Medicinal Mushroom ◽  
Asian Countries ◽  
Bioactive Components ◽  
Neuroprotective Effects ◽  
Made In

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P. linteus comprises various bioactive components, such as polysaccharides, triterpenoids, phenylpropanoids, and furans, and has proven to be an effective therapeutic agent in traditional Chinese medicine for the treatment and the prevention of various diseases. A number of studies have reported that P. linteus possesses many biological activities useful for pharmacological applications, including anticancer, anti-inflammatory, immunomodulatory, antioxidative, and antifungal activities, as well as antidiabetic, hepatoprotective, and neuroprotective effects. This review article briefly presents the recent progress made in understanding the bioactive components, biological activities, pharmacological applications, safety, and prospects of P. linteus, and provides helpful references and promising directions for further studies of P. linteus.

Recent progress in biological activities of synthesized phenothiazines

2011 ◽  
Vol 46 (8) ◽  
pp. 3179-3189 ◽  
Author(s):  
Krystian Pluta ◽  
Beata Morak-Młodawska ◽  
Małgorzata Jeleń
Keyword(s):  
Recent Progress ◽  
Biological Activities

scholarly journals Synthesis and Biological Activities of Natural Functionalized Polyamines: An Overview

2020 ◽  
Vol 27 ◽  
Author(s):  
Sophie Négrel ◽  
Jean Michel Brunel
Keyword(s):  
Recent Progress ◽  
Biological Activities ◽  
Human Use ◽  
Polyamine Derivatives ◽  
Fundamental Mechanism

: Recently, extensive researches have emphasized the fact that polyamines conjugates are becoming important in all the biological and medicinal fields. In this review we will focus our attention on natural polyamines and highlight recent progress in both fundamental mechanism studies and interest for the development and application for a therapeutic human use of polyamine derivatives.

Hypotensive effects of the triterpene oleanolic acid for cardiovascular prevention

2020 ◽  
Vol 13 ◽  
Author(s):  
A. Sureda ◽  
M. Monserrat-Mesquida ◽  
S. Pinya ◽  
P. Ferriol ◽  
S. Tejada
Keyword(s):  
Blood Pressure ◽  
Oleanolic Acid ◽  
Ex Vivo ◽  
Biological Activities ◽  
Cardiovascular Prevention ◽  
In Vivo Studies ◽  
Antihypertensive Activity ◽  
In Vitro Tests

Background:: Hypertension is a high prevalent chronic disease worldwide and a major cardiovascular risk factor. Oleanolic acid (3β-hydroxy-olea-12-en-28-oic acid) is a wide distributed bioactive pentacyclic triterpenoid with diverse biological activities such as anti-inflammatory, hepaprotective anti-diabetic or anti-hypertensive. Objective:: The aim of this study was to review and highlight the available data about antihypertensive activity of oleanolic acid and the described mechanisms of action. Method:: Extensive searches were made in the available literature on oleanolic acid and the data investigating its antihypertensive effects were analysed. Results:: Most of research has been performed on animal models of hypertension, ex vivo studies with aortic ring and some in vitro tests with cell cultures, whereas clinical trials are still lacking. Treatment of hypertensive animals with oleanolic acid significantly ameliorated the rise in the systolic blood pressure. In addition, the hypotensive effects of oleanolic acid are also related to a potent diuretic-natriuretic activity and nephroprotection. In vitro studies have characterized the participation of various signalling pathways that modulate the release of vasodilation mediators. Conclusion:: In vitro and in vivo studies suggest that oleanolic acid effectively reduce blood pressure and could be an interesting co-adjuvant to conventional treatment of hypertension.

scholarly journals A review of recent progress (2002-2012) on the biological activities of pyrazoles

ARKIVOC ◽  
2013 ◽  
Vol 2014 (2) ◽  
pp. 233-293 ◽  
Author(s):  
Ruth Pérez-Fernández ◽  
Pilar Goya ◽  
José Elguero
Keyword(s):  
Recent Progress ◽  
Biological Activities
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