ChemInform Abstract: Double C(sp3)-H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles.

ChemInform ◽  
2014 ◽  
Vol 45 (39) ◽  
pp. no-no
Author(s):  
Keiji Mori ◽  
Kazuki Kurihara ◽  
Shinnosuke Yabe ◽  
Masahiro Yamanaka ◽  
Takahiko Akiyama
Keyword(s):  
Bond Functionalization ◽  
Hydride Shift ◽  
Cyclization Process

Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp3)–H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process

2018 ◽  
Vol 140 (20) ◽  
pp. 6203-6207 ◽  
Author(s):  
Keiji Mori ◽  
Ryo Isogai ◽  
Yuto Kamei ◽  
Masahiro Yamanaka ◽  
Takahiko Akiyama
Keyword(s):  
Bond Functionalization ◽  
Hydride Shift ◽  
Cyclization Process

Double C(sp3)–H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles

2014 ◽  
Vol 136 (10) ◽  
pp. 3744-3747 ◽  
Author(s):  
Keiji Mori ◽  
Kazuki Kurihara ◽  
Shinnosuke Yabe ◽  
Masahiro Yamanaka ◽  
Takahiko Akiyama
Keyword(s):  
Bond Functionalization ◽  
Hydride Shift ◽  
Cyclization Process

C–H Bond Functionalization via [1,5]-Hydride Shift/Cyclization Sequence: Approach to Spiroindolenines

2015 ◽  
Vol 80 (2) ◽  
pp. 1155-1162 ◽  
Author(s):  
Peng-Fei Wang ◽  
Chun-Huan Jiang ◽  
Xiaoan Wen ◽  
Qing-Long Xu ◽  
Hongbin Sun
Keyword(s):  
Bond Functionalization ◽  
Hydride Shift

scholarly journals Stereoselective Synthesis of Highly-Congested Tetralin-Fused Spirooxindoles with Hydroxyl Group: Net Oxygen Atom Induced Hydride Shift/cyclization Process.

2021 ◽  
Author(s):  
Dan Sakai ◽  
mizuki machida ◽  
Keiji Mori
Keyword(s):  
Reaction Mechanism ◽  
Nitrogen Atom ◽  
Oxygen Atom ◽  
Stereoselective Synthesis ◽  
Hydroxyl Group ◽  
Target Structure ◽  
Hydride Shift ◽  
Cyclization Process ◽  
Stereogenic Centers

Highly stereoselective synthesis of tetralin-fused spirooxindoles with two contiguous stereogenic centers. In the present reaction, not only [1,5]-hydride shift/cyclization process, but also replacemnt of nitrogen atom to oxygen atom ocurred smoothly to give target structure with hydroxy grop in good chemical yields with good to excellent diastereoselectivities (up to d.r. = >20:1). Investigation of the reaction mechanism suggested that this “atom-replacement” event ocurred via the iminium cation intermediates.

Catalyst-free construction of spiro [benzoquinolizidine-chromanones] via a tandem condensation/1,5-hydride transfer/cyclization process

2020 ◽  
Vol 18 (43) ◽  
pp. 8839-8843
Author(s):  
Siyuan Liu ◽  
Hang Wang ◽  
Baomin Wang
Keyword(s):  
Hydride Transfer ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Hydride Shift ◽  
Cyclization Process ◽  
Free Construction

A highly efficient and quite mild protocol to achieve spiro [benzoquinoline-chromanones] through a catalyst-free condensation/[1,5]-hydride shift/6-endo cyclization sequence was developed.

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