ChemInform Abstract: Cinchona Alkaloid-Derived Thiourea-Catalyzed Diastereo- and Enantioselective [3 + 2] Cycloaddition Reaction of Isocyanoacetates to Isatins: A Facile Access to Optically Active Spirooxindole Oxazolines.

ChemInform ◽  
2013 ◽  
Vol 44 (38) ◽  
pp. no-no
Author(s):  
Mei-Xin Zhao ◽  
Hao Zhou ◽  
Wen-Hao Tang ◽  
Wei-Song Qu ◽  
Min Shi
Keyword(s):  
Cycloaddition Reaction ◽  
Optically Active ◽  
Cinchona Alkaloid

Synthesis of Optically Active 2,3-Disubstituted Indoline ­Derivatives through Cycloaddition Reactions between Benzynes and α,β-Unsaturated γ-Aminobutyronitriles

Synlett ◽  
2018 ◽  
Vol 29 (04) ◽  
pp. 530-536 ◽  
Author(s):  
Takashi Ikawa ◽  
Shuji Akai ◽  
Yuta Sumii ◽  
Shigeaki Masuda ◽  
Ding Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cycloaddition Reaction ◽  
Optically Active ◽  
Amino Acid Derivatives ◽  
Cycloaddition Reactions

We report a method for synthesizing optically active 2,3-disubstituted indolines by the cycloaddition reaction of benzynes with various 4-[(4-toluenesulfonyl)amino]-(E)-but-2-enenitriles, which are readily prepared from the corresponding l-amino acid derivatives.

Trienamine catalysis for asymmetric Diels–Alder reactions of 2,4-dienones: a theoretical investigation

2015 ◽  
Vol 13 (22) ◽  
pp. 6313-6324 ◽  
Author(s):  
Zhishan Su ◽  
Chan Kyung Kim
Keyword(s):  
Theoretical Investigation ◽  
Cycloaddition Reaction ◽  
Bifunctional Catalyst ◽  
Diels Alder ◽  
Cinchona Alkaloid

In the Diels–Alder reactions of 2,4-dienones with two dienophiles, cinchona alkaloid acts as an efficient bifunctional catalyst by generating an extended trienamine π-conjugated system and by orienting the dienophile at an appropriate position for a cycloaddition reaction.

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