Organocatalytic Asymmetric Formal [3+2] Cycloaddition Reaction of Isocyanoesters to Nitroolefins Leading to Highly Optically Active Dihydropyrroles

2008 ◽  
Vol 47 (18) ◽  
pp. 3414-3417 ◽  
Author(s):  
Chang Guo ◽  
Meng-Xia Xue ◽  
Ming-Kui Zhu ◽  
Liu-Zhu Gong
Keyword(s):  
Cycloaddition Reaction ◽  
Optically Active

Synthesis of Optically Active 2,3-Disubstituted Indoline ­Derivatives through Cycloaddition Reactions between Benzynes and α,β-Unsaturated γ-Aminobutyronitriles

Synlett ◽  
2018 ◽  
Vol 29 (04) ◽  
pp. 530-536 ◽  
Author(s):  
Takashi Ikawa ◽  
Shuji Akai ◽  
Yuta Sumii ◽  
Shigeaki Masuda ◽  
Ding Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cycloaddition Reaction ◽  
Optically Active ◽  
Amino Acid Derivatives ◽  
Cycloaddition Reactions

We report a method for synthesizing optically active 2,3-disubstituted indolines by the cycloaddition reaction of benzynes with various 4-[(4-toluenesulfonyl)amino]-(E)-but-2-enenitriles, which are readily prepared from the corresponding l-amino acid derivatives.

The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2′-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

2015 ◽  
Vol 51 (42) ◽  
pp. 8789-8792 ◽  
Author(s):  
Mingxia Ma ◽  
Yuanyuan Zhu ◽  
Quantao Sun ◽  
Xiaoyuan Li ◽  
Jinhuan Su ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Building Block ◽  
Cycloaddition Reaction ◽  
Optically Active ◽  
Dipolar Cycloaddition ◽  
New Strategy

A new strategy for the construction of optically active 5′-CF3 spiro[pyrrolidin-3,2′-oxindole] was described by using CF3CH2NH2 as a building block.

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