ChemInform Abstract: Novel Method for the Synthesis of α-Amino-α′-hydroxyalkylphosphinic Acids and Bis(α-aminoalkyl)phosphinic Acids: Nucleophilic Addition of α-Hydroxy-H-phosphinic Acids to Diimines.

ChemInform ◽  
2012 ◽  
Vol 43 (48) ◽  
pp. no-no
Author(s):  
Babak Kaboudin ◽  
Hamideh Haghighat ◽  
Saied Alaie ◽  
Tsutomu Yokomatsu
Keyword(s):  
Nucleophilic Addition ◽  
Phosphinic Acids ◽  
Novel Method

scholarly journals A novel family of (1-aminoalkyl)(trifluoromethyl)- and -(difluoromethyl)phosphinic acids – analogues of α-amino acids

2014 ◽  
Vol 10 ◽  
pp. 722-731
Author(s):  
Natalia V Pavlenko ◽  
Tatiana I Oos ◽  
Yurii L Yagupolskii ◽  
Igor I Gerus ◽  
Uwe Doeller ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ethyl Ester ◽  
Nucleophilic Addition ◽  
Phosphinic Acid ◽  
Double Bonds ◽  
Synthetic Methodology ◽  
One Pot ◽  
Phosphinic Acids

A series of novel (1-aminoalkyl)(trifluoromethyl)- and -(difluoromethyl)phosphinic acids – analogues of proteinogenic and nonproteinogenic α-amino acids were prepared. The synthetic methodology was based on nucleophilic addition of (trifluoromethyl)phosphinic acid or (difluoromethyl)phosphinic acid or its ethyl ester to substrates with C=N or activated C=C double bonds. Analogues of glycine, phenylglycine, alanine, valine, proline, aminomalonic and aspartic acids were thus prepared. Three-component one-pot reactions of (trifluoromethyl)phosphinic acid and dibenzylamine with aldehydes were also tested to prepare the title compounds.

Templated assembly of medium cyclic ethers via exo-trig nucleophilic cyclization of cyclopropenes

2016 ◽  
Vol 52 (47) ◽  
pp. 7494-7496 ◽  
Author(s):  
Bassam K. Alnasleh ◽  
Marina Rubina ◽  
Michael Rubin
Keyword(s):  
Nucleophilic Addition ◽  
Cyclic Ethers ◽  
Novel Method ◽  
Medium Rings ◽  
Nucleophilic Cyclization

A novel method for the assembly of medium heterocycles via an intramolecular nucleophilic addition to cyclopropenes is described. The exo-trig nucleophilic cyclizations were shown to proceed very efficiently and in a highly diastereoselective fashion affording cis-fused bicyclic products possessing 7 to 10-membered medium rings; starting from a diastereomeric mixtures of bromocyclopropanes.

The removal and morphology of intact biofilms from implanted venous access devices

1995 ◽  
Vol 53 ◽  
pp. 1020-1021
Author(s):  
M.A. Gregory ◽  
G.P. Hadley
Keyword(s):  
Patient Selection ◽  
Surgical Oncology ◽  
Venous Access ◽  
Common Procedure ◽  
Indwelling Catheters ◽  
Careful Patient ◽  
Novel Method ◽  
The Subject ◽  
Vascular Catheters ◽  
Venous Access Devices

The insertion of implanted venous access systems for children undergoing prolonged courses of chemotherapy has become a common procedure in pediatric surgical oncology. While not permanently implanted, the devices are expected to remain functional until cure of the primary disease is assured. Despite careful patient selection and standardised insertion and access techniques, some devices fail. The most commonly encountered problems are colonisation of the device with bacteria and catheter occlusion. Both of these difficulties relate to the development of a biofilm within the port and catheter. The morphology and evolution of biofilms in indwelling vascular catheters is the subject of ongoing investigation. To date, however, such investigations have been confined to the examination of fragments of biofilm scraped or sonicated from sections of catheter. This report describes a novel method for the extraction of intact biofilms from indwelling catheters.15 children with Wilm’s tumour and who had received venous implants were studied. Catheters were removed because of infection (n=6) or electively at the end of chemotherapy.

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