ChemInform Abstract: Diastereoselective Enzymatic Synthesis of Highly Substituted 3,4-Dihydropyridin-2-ones via Domino Knoevenagel Condensation-Michael Addition-Intramolecular Cyclization

ChemInform ◽  
2012 ◽  
Vol 43 (15) ◽  
pp. no-no
Author(s):  
Zhi-Qiang Liu ◽  
Bo-Kai Liu ◽  
Qi Wu ◽  
Xian-Fu Lin
Keyword(s):  
Intramolecular Cyclization ◽  
Michael Addition ◽  
Enzymatic Synthesis ◽  
Knoevenagel Condensation

Nmp-based ionic liquids: Recyclable catalysts for both hetero-Michael addition and Knoevenagel condensation in water

2018 ◽  
Vol 48 (9) ◽  
pp. 1060-1067 ◽  
Author(s):  
Pengkun Yang ◽  
Yawei Liu ◽  
Ling Chai ◽  
Zhenzhen Lai ◽  
Xiaomin Fang ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Recyclable Catalysts

Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues

2021 ◽  
Author(s):  
Chao Liu ◽  
Ruiqi Zhao ◽  
Liangliang Song ◽  
Zhenghua Li ◽  
Guilong Tian ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
Michael Addition ◽  
Highly Efficient ◽  
Palladium Catalyzed

A palladium-catalyzed intramolecular cyclization of Ugi-adducts via a cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the...

Diversity-Oriented Synthesis via Catalyst-Free Addition of Ketones to [e]-Fused 1H-Pyrrole-2,3-diones

Synthesis ◽  
2018 ◽  
Vol 50 (24) ◽  
pp. 4897-4904 ◽  
Author(s):  
Ekaterina Stepanova ◽  
Andrey Maslivets ◽  
Svetlana Kasatkina ◽  
Maksim Dmitriev
Keyword(s):  
Intramolecular Cyclization ◽  
Aromatic Hydrocarbons ◽  
Michael Addition ◽  
Aldol Reaction ◽  
Synthetic Approach ◽  
Reaction Conditions ◽  
Diversity Oriented Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Reaction Proceeds

A facile synthetic approach towards two distinct pyrrole-based heterocyclic scaffolds has been developed by the interaction of 1H-pyrrole-2,3-diones fused at the [e]-side to a 1,4-benzoxazin-2-one or quinoxalin-2(1H)-one moiety with ketones. The described interaction proceeds either as an aldol reaction or as a Michael addition/intramolecular cyclization depending on the reaction conditions. The disclosed aldol reaction proceeds with good diastereoselectivity under catalyst-free conditions when the reaction is carried out in aromatic hydrocarbons. Products of the cascade Michael addition/intramolecular cyclization reaction are predominantly formed under catalyst-free and solvent-free conditions. The proposed strategy provides facile access to pharmaceutically interesting pyrrole-based polyheterocycles.

scholarly journals Enzymatic synthesis of unsaturated polyesters: functionalization and reversibility of the aza-Michael addition of pendants

2019 ◽  
Vol 10 (7) ◽  
pp. 843-851 ◽  
Author(s):  
Alessandro Pellis ◽  
Polly Ann Hanson ◽  
James W. Comerford ◽  
James H. Clark ◽  
Thomas J. Farmer
Keyword(s):  
Michael Addition ◽  
Enzymatic Synthesis ◽  
Temperature Dependent ◽  
Unsaturated Polyesters ◽  
Diethyl Amine

Enzymatic synthesis of unsaturated polyesters and the temperature-dependent reversibility of the aza-Michael addition of diethyl amine pendants.

Water-prompted synthesis of alkyl nitrile derivatives via Knoevenagel condensation and Michael addition reaction

2011 ◽  
Vol 13 (3) ◽  
pp. 566 ◽  
Author(s):  
Ebrahim Soleimani ◽  
Mohammad Mehdi Khodaei ◽  
Nasim Batooie ◽  
Mostafa Baghbanzadeh
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Knoevenagel Condensation ◽  
Michael Addition Reaction
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