ChemInform Abstract: Unexpected Formation of 4,4,6-Trimethyl-2-oxo-1-phenyl-1,2,3,4-tetrahydropyridine-3-carbonitrile via Tandem Knoevenagel Condensation-Michael Addition-Intramolecular Cyclization.

ChemInform ◽  
2010 ◽  
Vol 41 (20) ◽  
Author(s):  
A. A. Nikishin ◽  
V. D. Dyachenko ◽  
A. N. Chernega
Keyword(s):  
Intramolecular Cyclization ◽  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Unexpected Formation

Nmp-based ionic liquids: Recyclable catalysts for both hetero-Michael addition and Knoevenagel condensation in water

2018 ◽  
Vol 48 (9) ◽  
pp. 1060-1067 ◽  
Author(s):  
Pengkun Yang ◽  
Yawei Liu ◽  
Ling Chai ◽  
Zhenzhen Lai ◽  
Xiaomin Fang ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Recyclable Catalysts

Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues

2021 ◽  
Author(s):  
Chao Liu ◽  
Ruiqi Zhao ◽  
Liangliang Song ◽  
Zhenghua Li ◽  
Guilong Tian ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
Michael Addition ◽  
Highly Efficient ◽  
Palladium Catalyzed

A palladium-catalyzed intramolecular cyclization of Ugi-adducts via a cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the...

Diversity-Oriented Synthesis via Catalyst-Free Addition of Ketones to [e]-Fused 1H-Pyrrole-2,3-diones

Synthesis ◽  
2018 ◽  
Vol 50 (24) ◽  
pp. 4897-4904 ◽  
Author(s):  
Ekaterina Stepanova ◽  
Andrey Maslivets ◽  
Svetlana Kasatkina ◽  
Maksim Dmitriev
Keyword(s):  
Intramolecular Cyclization ◽  
Aromatic Hydrocarbons ◽  
Michael Addition ◽  
Aldol Reaction ◽  
Synthetic Approach ◽  
Reaction Conditions ◽  
Diversity Oriented Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Reaction Proceeds

A facile synthetic approach towards two distinct pyrrole-based heterocyclic scaffolds has been developed by the interaction of 1H-pyrrole-2,3-diones fused at the [e]-side to a 1,4-benzoxazin-2-one or quinoxalin-2(1H)-one moiety with ketones. The described interaction proceeds either as an aldol reaction or as a Michael addition/intramolecular cyclization depending on the reaction conditions. The disclosed aldol reaction proceeds with good diastereoselectivity under catalyst-free conditions when the reaction is carried out in aromatic hydrocarbons. Products of the cascade Michael addition/intramolecular cyclization reaction are predominantly formed under catalyst-free and solvent-free conditions. The proposed strategy provides facile access to pharmaceutically interesting pyrrole-based polyheterocycles.

Water-prompted synthesis of alkyl nitrile derivatives via Knoevenagel condensation and Michael addition reaction

2011 ◽  
Vol 13 (3) ◽  
pp. 566 ◽  
Author(s):  
Ebrahim Soleimani ◽  
Mohammad Mehdi Khodaei ◽  
Nasim Batooie ◽  
Mostafa Baghbanzadeh
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Knoevenagel Condensation ◽  
Michael Addition Reaction
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