ChemInform Abstract: Synthesis of Some Novel N-Alkyl/Acyl/Aroyl 2-(Chroman/6-bromochroman-2-yl)-1H-benzimidazoles Using Ionic Liquids and Their Antibacterial Activity.

ChemInform ◽  
2010 ◽  
Vol 41 (42) ◽  
Author(s):  
Changdev Namdev Raut ◽  
Sandeep Madhukar Bagul ◽  
Ravindra Ashok Janrao ◽  
Sanjay Dashrath Vaidya ◽  
Bobba Venkata Siva Kumar ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids

scholarly journals Synthesis, antibiotic structure–activity relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Shihong Liu ◽  
Michael Gonzalez ◽  
Celine Kong ◽  
Scott Weir ◽  
Aaron M. Socha
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids ◽  
Room Temperature ◽  
Oxidation Products ◽  
Cellulose Dissolution ◽  
Melting Points ◽  
E Coli ◽  
Alkyl Chains ◽  
Renewable Feedstocks ◽  
Commodity Chemicals

Abstract Background Ionic liquids (ILs) are promising pretreatment solvents for lignocellulosic biomass, but are largely prepared from petroleum precursors. Benzaldehydes from depolymerized lignin, such as vanillin, syringaldehyde, and 4-methoxy benzaldehyde, represent renewable feedstocks for the synthesis of ionic liquids. We herein report syntheses of novel lignin-derived ionic liquids, with extended N-alkyl chains, and examine their melting points, cellulose dissolution capacities, and toxicity profiles against Daphnia magna and E. coli strain 1A1. The latter organism has been engineered to produce isoprenol, a drop-in biofuel and precursor for commodity chemicals. Results The new N,N-diethyl and N,N-dipropyl methyl benzylammonium ILs were liquids at room temperature, showing 75–100 °C decreased melting points as compared to their N,N,N-trimethyl benzylammonium analog. Extension of N-alkyl chains also increased antibacterial activity threefold, while ionic liquids prepared from vanillin showed 2- to 4-fold lower toxicity as compared to those prepared from syringaldehyde and 4-methoxybenzaldehyde. The trend of antibacterial activity for anions of lignin-derived ILs was found to be methanesulfonate < acetate < hydroxide. Microcrystalline cellulose dissolution, from 2 to 4 wt% after 20 min at 100 °C, was observed in all new ILs using light microscopy and IR spectroscopy. Conclusions Ionic liquids prepared from H-, S- and G-lignin oxidation products provided differential cytotoxic activity against E. coli and D. magna, suggesting these compounds could be tailored for application specificity within a biorefinery.

In-vitro cytotoxicity, synergistic antibacterial activity and interaction studies of imidazolium-based ionic liquids with levofloxacin

2021 ◽  
Vol 325 ◽  
pp. 115125
Author(s):  
Md. Abrar Siddiquee ◽  
Juhi Saraswat ◽  
Khalid Imtiyaz ◽  
Ab Raouf Bhat ◽  
Farooq Ahmad Wani ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids ◽  
In Vitro Cytotoxicity ◽  
Interaction Studies ◽  
Synergistic Antibacterial Activity

Antibacterial Activity of Imidazolium-Based Ionic Liquids Investigated by QSAR Modeling and Experimental Studies

2016 ◽  
Vol 88 (3) ◽  
pp. 422-433 ◽  
Author(s):  
Diana Hodyna ◽  
Vasyl Kovalishyn ◽  
Sergiy Rogalsky ◽  
Volodymyr Blagodatnyi ◽  
Kirill Petko ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids ◽  
Experimental Studies ◽  
Qsar Modeling

scholarly journals New Eco-Friendly 1-Alkyl-3-(4-phenoxybutyl) Imidazolium-Based Ionic Liquids Derivatives: A Green Ultrasound-Assisted Synthesis, Characterization, Antibacterial Activity and POM Analyses

Molecules ◽  
2014 ◽  
Vol 19 (8) ◽  
pp. 11741-11759 ◽  
Author(s):  
Mouslim Messali ◽  
Mohamed Aouad ◽  
Wael El-Sayed ◽  
Adeeb Al-Sheikh Ali ◽  
Taibi Ben Hadda ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids ◽  
Pom Analyses ◽  
Ultrasound Assisted

scholarly journals Synthesis, antibiotic structure-activity-relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin

2021 ◽  
Author(s):  
Shihong Liu ◽  
Michael Gonzalez ◽  
Celine Kong ◽  
Scott Weir ◽  
Aaron Socha
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids ◽  
Room Temperature ◽  
Oxidation Products ◽  
Cellulose Dissolution ◽  
Melting Points ◽  
E Coli ◽  
Alkyl Chains ◽  
Renewable Feedstocks ◽  
Commodity Chemicals

Abstract Background: Ionic liquids (ILs) are promising pretreatment solvents for lignocellulosic biomass, but are largely prepared from petroleum precursors. Benzaldehydes from depolymerized lignin, such as vanillin, syringaldehyde, and 4-methoxy benzaldehyde, represent renewable feedstocks for the synthesis of ionic liquids. We herein report syntheses of novel lignin-derived ionic liquids, with extended N-alkyl chains, and examine their melting points, cellulose dissolution capacities, and toxicity profiles against Daphnia magna and E. coli strain 1A1. The latter organism has been engineered to produce isoprenol, a drop-in biofuel and precursor for commodity chemicals. Results: The new N,N-diethyl and N,N-dipropyl methyl benzylammonium ILs were liquids at room temperature, showing 75-100oC decreased melting points as compared to their N,N,N-trimethyl benzylammonium analog. Extension of N-alkyl chains also increased antibacterial activity 3-fold, while ionic liquids prepared from vanillin showed 2- to 4-fold lower toxicity as compared to those prepared from syringaldehyde and 4-methoxybenzaldehyde. The trend of antibacterial activity for anions of lignin-derived ILs was found to be methanesulfonate < acetate < hydroxide. Microcrystalline cellulose dissolution, from 2-4 wt% after 20 min at 100oC, was observed in all new ILs using light microscopy and IR spectroscopy.Conclusions: Ionic liquids prepared from H-, S- and G-lignin oxidation products provided differential cytotoxic activity against E.coli and D. magna, suggesting these compounds could be tailored for application specificity within a biorefinery.

Mechanism of Antibacterial Activity of Choline-Based Ionic Liquids (CAGE)

2018 ◽  
Vol 4 (7) ◽  
pp. 2370-2379 ◽  
Author(s):  
Kelly N. Ibsen ◽  
Huilin Ma ◽  
Amrita Banerjee ◽  
Eden E. L. Tanner ◽  
Shikha Nangia ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids

Bis-imidazolium and benzimidazolium based gemini-type ionic liquids structure: synthesis and antibacterial evaluation

RSC Advances ◽  
2015 ◽  
Vol 5 (112) ◽  
pp. 92602-92617 ◽  
Author(s):  
Nassir N. Al-Mohammed ◽  
Yatimah Alias ◽  
Zanariah Abdullah
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids ◽  
Structure Synthesis ◽  
Antibacterial Evaluation

The incorporated benzenesulfonamide moiety and the active side substituents in di-imidazolium and benzimidazolium cations enhanced both antibacterial activity and miscibility for the synthesized gemini type ILs.

scholarly journals Antibacterial activity of Ionic Liquids based on ampicillin against resistant bacteria

RSC Advances ◽  
2014 ◽  
Vol 4 (9) ◽  
pp. 4301-4307 ◽  
Author(s):  
Ricardo Ferraz ◽  
Vânia Teixeira ◽  
Débora Rodrigues ◽  
Rúben Fernandes ◽  
Cristina Prudêncio ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ionic Liquids ◽  
Resistant Bacteria
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