ChemInform Abstract: Catalytic Asymmetric Conjugated Addition Reactions of Organometallic Reagents

ChemInform ◽  
2010 ◽  
Vol 41 (35) ◽  
pp. no-no
Author(s):  
Fernando Lopez ◽  
Ben L. Feringa
Keyword(s):  
Addition Reactions ◽  
Organometallic Reagents ◽  
Catalytic Asymmetric

Catalytic Asymmetric Direct-Type 1,4-Addition Reactions of Simple Amides

2015 ◽  
Vol 137 (13) ◽  
pp. 4336-4339 ◽  
Author(s):  
Hirotsugu Suzuki ◽  
Io Sato ◽  
Yasuhiro Yamashita ◽  
Shu̅ Kobayashi
Keyword(s):  
Addition Reactions ◽  
Catalytic Asymmetric

A Strategy for Synthesizing Axially Chiral Naphthyl‐Indoles: Catalytic Asymmetric Addition Reactions of Racemic Substrates

2019 ◽  
Vol 131 (42) ◽  
pp. 15248-15254 ◽  
Author(s):  
Fei Jiang ◽  
Ke‐Wei Chen ◽  
Ping Wu ◽  
Yu‐Chen Zhang ◽  
Yinchun Jiao ◽  
...  
Keyword(s):  
Addition Reactions ◽  
Asymmetric Addition ◽  
Axially Chiral ◽  
Catalytic Asymmetric

Catalytic asymmetric addition reactions leading to carbon-carbon bond formation: Phenyl and alkenyl transfer to aldehydes and alkynylation of α-imino esters

2006 ◽  
Vol 78 (2) ◽  
pp. 267-274 ◽  
Author(s):  
Jian-Xin Ji ◽  
Jing Wu ◽  
Lijin Xu ◽  
Chiu-Wing Yip ◽  
Kim Hung Lam ◽  
...  
Keyword(s):  
Bond Formation ◽  
Optically Active ◽  
Amino Acid Derivatives ◽  
Addition Reactions ◽  
Terminal Alkynes ◽  
Reaction Conditions ◽  
Carbon Carbon Bond ◽  
Catalytic Asymmetric ◽  
High Yields ◽  
Imino Esters

Optically active tertiary aminonaphthol ligands were obtained by a new, convenient procedure and were found to catalyze the enantioselective alkenyl and phenyl transfer to aldehydes in high yields and excellent enantiomeric excesses (ee's). The catalytic asymmetric introduction of alkynyl functionality to α-amino acid derivatives was realized by the direct addition of terminal alkynes to α-imino ester in the presence of chiral copper(I) complex under mild reaction conditions.

Catalytic Asymmetric 1,4-Addition Reactions Using α,β-UnsaturatedN-Acylpyrroles as Highly Reactive Monodentate α,β-Unsaturated Ester Surrogates

2004 ◽  
Vol 126 (24) ◽  
pp. 7559-7570 ◽  
Author(s):  
Shigeki Matsunaga ◽  
Tomofumi Kinoshita ◽  
Shigemitsu Okada ◽  
Shinji Harada ◽  
Masakatsu Shibasaki
Keyword(s):  
Unsaturated Ester ◽  
Addition Reactions ◽  
Catalytic Asymmetric

ChemInform Abstract: Catalytic Asymmetric 1,4-Addition Reactions of Simple Alkylnitriles.

ChemInform ◽  
2016 ◽  
Vol 47 (6) ◽  
pp. no-no
Author(s):  
Yasuhiro Yamashita ◽  
Io Sato ◽  
Hirotsugu Suzuki ◽  
Shu Kobayashi
Keyword(s):  
Addition Reactions ◽  
Catalytic Asymmetric

scholarly journals Nucleophilic Dearomatization of Activated Pyridines

Catalysts ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 632 ◽  
Author(s):  
Giulio Bertuzzi ◽  
Luca Bernardi ◽  
Mariafrancesca Fochi
Keyword(s):  
Nitrogen Heterocycles ◽  
Dipolar Cycloaddition ◽  
Cycloaddition Reactions ◽  
Organometallic Reagents ◽  
Pyridine Nitrogen ◽  
Pyridinium Ylides ◽  
Catalytic Asymmetric ◽  
Synthetic Approaches ◽  
Nitrogen Functionalization ◽  
Pyridinium Ion

Amongst nitrogen heterocycles of different ring sizes and oxidation statuses, dihydropyridines (DHP) occupy a prominent role due to their synthetic versatility and occurrence in medicinally relevant compounds. One of the most straightforward synthetic approaches to polysubstituted DHP derivatives is provided by nucleophilic dearomatization of readily assembled pyridines. In this article, we collect and summarize nucleophilic dearomatization reactions of - pyridines reported in the literature between 2010 and mid-2018, complementing and updating previous reviews published in the early 2010s dedicated to various aspects of pyridine chemistry. Since functionalization of the pyridine nitrogen, rendering a (transient) pyridinium ion, is usually required to render the pyridine nucleus sufficiently electrophilic to suffer the attack of a nucleophile, the material is organized according to the type of N-functionalization. A variety of nucleophilic species (organometallic reagents, enolates, heteroaromatics, umpoled aldehydes) can be productively engaged in pyridine dearomatization reactions, including catalytic asymmetric implementations, providing useful and efficient synthetic platforms to (enantioenriched) DHPs. Conversely, pyridine nitrogen functionalization can also lead to pyridinium ylides. These dipolar species can undergo a variety of dipolar cycloaddition reactions with electron-poor dipolarophiles, affording polycyclic frameworks and embedding a DHP moiety in their structures.

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