ChemInform Abstract: Locked Nucleic Acids: Promising Nucleic Acid Analogues for Therapeutic Applications

ChemInform ◽  
2010 ◽  
Vol 41 (24) ◽  
pp. no-no
Author(s):  
Rakesh N. Veedu ◽  
Jesper Wengel
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Therapeutic Applications ◽  
Locked Nucleic Acids ◽  
Nucleic Acid Analogues

scholarly journals Bridged Nucleic Acids Reloaded

2019 ◽  
Author(s):  
Alfonso Soler-Bistué ◽  
Angeles Zorreguieta ◽  
Marcelo E. Tolmasky
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
First Generation ◽  
Second Generation ◽  
Nucleotide Analogs ◽  
Great Hope ◽  
Locked Nucleic Acids ◽  
Near Future

Oligonucleotides are key compounds widely used for research, diagnostics, and therapeutics. The rapid increase in oligonucleotide-based applications, together with the progress in nucleic acids research, led to the design of nucleotide analogs that when being part of these oligomers enhance their efficiency, bioavailability, or stability. One of the most useful nucleotide analogs are the first-generation bridge nucleic acids (BNA), also known as locked nucleic acids (LNA), which were used in combination with ribonucleotides, deoxyribonucleotides, or other analogs to construct oligomers with diverse applications. However, there is still room to improve their efficiency, bioavailability, stability, and, importantly, toxicity. A second generation BNA, BNANC (2'-O,4'-aminoethylene bridged nucleic acid), has been recently made available. Oligomers containing these analogs not only showed less toxicity when compared to LNA-containing compounds but in some cases also exhibited higher specificity. Although there are still few applications where BNANC-containing compounds were researched, the results are very promising warranting more efforts in incorporating these analogs for other applications. Furthermore, newer BNA compounds will be introduced in the near future offering great hope to oligonucleotide-based fields of research and applications.

scholarly journals Bridged Nucleic Acids Reloaded

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2297 ◽  
Author(s):  
Alfonso Soler-Bistué ◽  
Angeles Zorreguieta ◽  
Marcelo E. Tolmasky
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
First Generation ◽  
Second Generation ◽  
Nucleotide Analogs ◽  
Great Hope ◽  
Locked Nucleic Acids ◽  
Near Future

Oligonucleotides are key compounds widely used for research, diagnostics, and therapeutics. The rapid increase in oligonucleotide-based applications, together with the progress in nucleic acids research, has led to the design of nucleotide analogs that, when part of these oligomers, enhance their efficiency, bioavailability, or stability. One of the most useful nucleotide analogs is the first-generation bridged nucleic acids (BNA), also known as locked nucleic acids (LNA), which were used in combination with ribonucleotides, deoxyribonucleotides, or other analogs to construct oligomers with diverse applications. However, there is still room to improve their efficiency, bioavailability, stability, and, importantly, toxicity. A second-generation BNA, BNANC (2′-O,4′-aminoethylene bridged nucleic acid), has been recently made available. Oligomers containing these analogs not only showed less toxicity when compared to LNA-containing compounds but, in some cases, also exhibited higher specificity. Although there are still few applications where BNANC-containing compounds have been researched, the promising results warrant more effort in incorporating these analogs for other applications. Furthermore, newer BNA compounds will be introduced in the near future, offering great hope to oligonucleotide-based fields of research and applications.

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

1998 ◽  
pp. 455-456 ◽  
Author(s):  
Sanjay K. Singh ◽  
Alexei A. Koshkin ◽  
Jesper Wengel ◽  
Poul Nielsen
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
High Affinity ◽  
Locked Nucleic Acids

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Tetrahedron ◽  
1998 ◽  
Vol 54 (14) ◽  
pp. 3607-3630 ◽  
Author(s):  
Alexei A. Koshkin ◽  
Sanjay K. Singh ◽  
Poul Nielsen ◽  
Vivek K. Rajwanshi ◽  
Ravindra Kumar ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Locked Nucleic Acids

ChemInform Abstract: LNA (Locked Nucleic Acids): Synthesis and High-Affinity Nucleic Acid Recognition.

ChemInform ◽  
2010 ◽  
Vol 29 (26) ◽  
pp. no-no
Author(s):  
S. K. SINGH ◽  
P. NIELSEN ◽  
A. A. KOSHKIN ◽  
J. WENGEL
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
High Affinity ◽  
Locked Nucleic Acids

Biological applications of xeno nucleic acids

2017 ◽  
Vol 13 (2) ◽  
pp. 235-245 ◽  
Author(s):  
Kunihiko Morihiro ◽  
Yuuya Kasahara ◽  
Satoshi Obika
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Antisense Oligonucleotides ◽  
Biological Applications ◽  
Chemically Modified ◽  
Nucleic Acid Analogues

Xeno nucleic acids (XNAs) are a group of chemically modified nucleic acid analogues that have been applied to various biological technologies such as antisense oligonucleotides, siRNAs and aptamers.

Scaffolding along Nucleic Acid Duplexes Using 2′-Amino-Locked Nucleic Acids

2014 ◽  
Vol 47 (6) ◽  
pp. 1768-1777 ◽  
Author(s):  
I. Kira Astakhova ◽  
Jesper Wengel
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Locked Nucleic Acids
Sign in / Sign up

Export Citation Format

Share Document