ChemInform Abstract: Skin Permeation and Transdermal Delivery Systems of Drugs: History to Overcome Barrier Function in the Stratum Corneum.

ChemInform ◽  
2010 ◽  
Vol 41 (19) ◽  
Author(s):  
Masahiro Sugino ◽  
Hiroaki Todo ◽  
Kenji Sugibayashi
Keyword(s):  
Stratum Corneum ◽  
Barrier Function ◽  
Transdermal Delivery ◽  
Skin Permeation ◽  
Delivery Systems

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

Microneedle-mediated transdermal nanodelivery systems: a review

2021 ◽  
Author(s):  
Shuyao Ruan ◽  
Yong-Tai Zhang ◽  
Nian-Ping Feng
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Barrier Function ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Drug Delivery Systems

The greatest limitation in the development of transdermal drug delivery systems is that only a few drugs can permeate the skin due to the barrier function of the stratum corneum....

Comparative Controlled Skin Permeation of Nitroglycerin from Marketed Transdermal Delivery Systems

1983 ◽  
Vol 72 (8) ◽  
pp. 968-970 ◽  
Author(s):  
Yie W. Chien ◽  
Prakash R. Keshary ◽  
Yih C. Huang ◽  
Pramod P. Sarpotdar
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Delivery Systems

scholarly journals Recent Advances in Nanomaterials for Dermal and Transdermal Applications

2021 ◽  
Vol 5 (1) ◽  
pp. 18
Author(s):  
Amani Zoabi ◽  
Elka Touitou ◽  
Katherine Margulis
Keyword(s):  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Polymeric Nanoparticles ◽  
Skin Permeation ◽  
Superficial Layer ◽  
The Body ◽  
Local Concentration ◽  
Cosmetic Products ◽  
Recent Advances ◽  
The Stability

The stratum corneum, the most superficial layer of the skin, protects the body against environmental hazards and presents a highly selective barrier for the passage of drugs and cosmetic products deeper into the skin and across the skin. Nanomaterials can effectively increase the permeation of active molecules across the stratum corneum and enable their penetration into deeper skin layers, often by interacting with the skin and creating the distinct sites with elevated local concentration, acting as reservoirs. The flux of the molecules from these reservoirs can be either limited to the underlying skin layers (for topical drug and cosmeceutical delivery) or extended across all the sublayers of the epidermis to the blood vessels of the dermis (for transdermal delivery). The type of the nanocarrier and the physicochemical nature of the active substance are among the factors that determine the final skin permeation pattern and the stability of the penetrant in the cutaneous environment. The most widely employed types of nanomaterials for dermal and transdermal applications include solid lipid nanoparticles, nanovesicular carriers, microemulsions, nanoemulsions, and polymeric nanoparticles. The recent advances in the area of nanomaterial-assisted dermal and transdermal delivery are highlighted in this review.

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