ChemInform Abstract: Cyclopalladated Compounds as Resolving Agents for Racemic Mixtures of Ligands

ChemInform ◽  
2010 ◽  
Vol 41 (10) ◽  
Author(s):  
Jean-Pierre Djukic
Keyword(s):  
Racemic Mixtures ◽  
Resolving Agents ◽  
Cyclopalladated Compounds

scholarly journals Resolution of Racemic Mixtures by Phase Transition of PEGylated Resolving Agents

ACS Omega ◽  
2017 ◽  
Vol 2 (12) ◽  
pp. 8717-8722
Author(s):  
Javad Mokhtari ◽  
Sahar Azarnoosh ◽  
Khashayar Karimian
Keyword(s):  
Phase Transition ◽  
Racemic Mixtures ◽  
Resolving Agents

scholarly journals Syntheses, Characterization, Resolution, and Biological Studies of Coordination Compounds of Aspartic Acid and Glycine

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Temitayo Aiyelabola ◽  
Ezekiel Akinkunmi ◽  
Isaac Ojo ◽  
Efere Obuotor ◽  
Clement Adebajo ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Coordination Compounds ◽  
Biological Activities ◽  
Enantiomeric Purity ◽  
Cytotoxic Agents ◽  
Cytotoxic Activities ◽  
Biological Studies ◽  
Racemic Mixtures ◽  
Resolving Agents ◽  
Metal Ligand

Enantiomerically enriched coordination compounds of aspartic acid and racemic mixtures of coordination compounds of glycine metal-ligand ratio 1 : 3 were synthesized and characterized using infrared and UV-Vis spectrophotometric techniques and magnetic susceptibility measurements. Five of the complexes were resolved using (+)-cis-dichlorobis(ethylenediamine)cobalt(III) chloride, (+)-bis(glycinato)(1,10-phenanthroline)cobalt(III) chloride, and (+)-tris(1,10-phenanthroline)nickel(II) chloride as resolving agents. The antimicrobial and cytotoxic activities of these complexes were then determined. The results obtained indicated that aspartic acid and glycine coordinated in a bidentate fashion. The enantiomeric purity of the compounds was in the range of 22.10–32.10%, with (+)-cis-dichlorobis(ethylenediamine)cobalt(III) complex as the more efficient resolving agent. The resolved complexes exhibited better activity in some cases compared to the parent complexes for both biological activities. It was therefore inferred that although the increase in the lipophilicity of the complexes may assist in the permeability of the complexes through the cell membrane of the pathogens, the enantiomeric purity of the complexes is also of importance in their activity as antimicrobial and cytotoxic agents.

Separation and Characterization of Standard Propoxyphene Diastereomers and Their Determination in Pharmaceutical and Illicit Preparations

1981 ◽  
Vol 64 (4) ◽  
pp. 875-883
Author(s):  
Shiv K Soni ◽  
Daniel Van Gelder
Keyword(s):  
High Pressure ◽  
Optical Isomers ◽  
Gold Chloride ◽  
Melting Points ◽  
Eutectic Melting ◽  
Racemic Mixtures ◽  
The Individual ◽  
Isomeric Mixtures ◽  
Asymmetric Carbon

Abstract Due to the existence of 2 asymmetric carbon atoms in: the propoxyphene molecule, there are 4 diastereomers: alpha dextro, alpha levo, beta dextro, and beta levo. Only α-d-propoxyphene is included under the federal Controlled Substances Act. Baseline separations of propoxyphene from various incipients (aspirin, caffeine, phenacetin, and acetaminophen) present in pharmaceutical and illicit preparations, and between the alpha and beta diastereomers, were achieved by high pressure liquid chromatography. The column eluant was collected and propoxyphene was extracted. The optical isomers were differentiated and characterized by melting points and by chemical microcrystalline tests. Using hot stage thermomicroscopy, the eutectic melting points of binary isomeric mixtures of propoxyphene bases and salts were found to be depressed about 10° and 15-30°C, respectively, below the individual isomer melting points. The characteristic microcrystals formed with the alpha racemic mixtures by using a glycerin-aqueous gold chloride reagent were not produced by the beta racemic mixtures.

A computational study of the chromatographic separation of racemic mixtures

1995 ◽  
Vol 41 (5-6) ◽  
pp. 161-166 ◽  
Author(s):  
A. M. Edge ◽  
D. M. Heaton ◽  
K. D. Bartle ◽  
A. A. Clifford ◽  
P. Myers
Keyword(s):  
Chromatographic Separation ◽  
Computational Study ◽  
Racemic Mixtures
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