A computational study of the chromatographic separation of racemic mixtures

1995 ◽  
Vol 41 (5-6) ◽  
pp. 161-166 ◽  
Author(s):  
A. M. Edge ◽  
D. M. Heaton ◽  
K. D. Bartle ◽  
A. A. Clifford ◽  
P. Myers
Keyword(s):  
Chromatographic Separation ◽  
Computational Study ◽  
Racemic Mixtures

A computational study of the chromatographic separation of racemic mixtures

1995 ◽  
Vol 41 (3-4) ◽  
pp. 161-166 ◽  
Author(s):  
A. M. Edge ◽  
D. M. Heaton ◽  
K. D. Bartle ◽  
A. A. Clifford ◽  
P. Myers
Keyword(s):  
Chromatographic Separation ◽  
Computational Study ◽  
Racemic Mixtures

scholarly journals Computational study of the chromatographic enantioseparation of tris(acetylacetonato)cobalt(III) complexes on an arginine complex of cobalt(III) acting as a chiral selector

2002 ◽  
Vol 67 (11) ◽  
pp. 735-744 ◽  
Author(s):  
Ljiljana Cuckovic ◽  
Ismet Hodzic ◽  
Svetozar Niketic
Keyword(s):  
Total Energy ◽  
Chromatographic Separation ◽  
Predictive Power ◽  
Computational Study ◽  
Stationary Phases ◽  
Chiral Selector ◽  
Experimental Results ◽  
Elution Order ◽  
Practical Applications ◽  
Energy Of Interaction

Acomputational procedure for the modelling of chromatographic separation of neutral tris(acetylacetonato)cobalt(III) into enantiomers on a dinitrobis(arginine)cobalt(III) complex as a chiral selector is described. Predicted elution order calculated from the differences in total energy of interaction for ? and ? selectands is in agreement with the experimental results. Predictive power of the method and its possible practical applications in designing efficient chiral stationary phases is demonstrated.

DETERMINATION OF MICRO-AMOUNTS OF 5β-PREGNAN-3α-OL-20-ONE IN URINE USING INFRARED-SPECTROMETRY

1962 ◽  
Vol 41 (2) ◽  
pp. 234-246 ◽  
Author(s):  
H. J. van der Molen
Keyword(s):  
Infrared Spectrum ◽  
Quantitative Determination ◽  
Acid Hydrolysis ◽  
Chromatographic Separation ◽  
Pure Form ◽  
Infrared Spectrometry ◽  
Hydrolysis Of

ABSTRACT A procedure for the quantitative determination of 5β-pregnan-3α-ol-20-one in urine is described. After acid hydrolysis of the pregnanolone-conjugates in urine, the free steroids are extracted with toluene. Pregnanolone is isolated in a pure form as its acetate; after chromatographic separation of the free steroids on alumina, the fraction containing pregnanolone is acetylated and rechromatographed on alumina. Quantitative determination of the isolated pregnanolone-acetate is carried out with the aid of the infrared spectrum recorded by a micro KBr-wafermethod. The reliability of the method under various conditions is discussed under the headings, specificity, accuracy, precision and sensitivity. It is possible to determine 30–40 μg pregnanolone in a 24-hours urine portion with a precision of 25%.

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