ChemInform Abstract: Heterogeneous Asymmetric Catalysis in Water with Amphiphilic Polymer-Supported Homochiral Palladium Complexes

ChemInform ◽  
2009 ◽  
Vol 40 (1) ◽  
Author(s):  
Yasuhiro Uozumi
Keyword(s):  
Asymmetric Catalysis ◽  
Palladium Complexes ◽  
Amphiphilic Polymer ◽  
Polymer Supported ◽  
Heterogeneous Asymmetric Catalysis

scholarly journals Chiral salen complexes in polymeric main-chains for heterogeneous asymmetric catalysis - a brief account

2020 ◽  
Vol 58 (1) ◽  
pp. 29-39
Author(s):  
Hiba Dandachi ◽  
Xiang Hong ◽  
Farah Ibrahim ◽  
Houssein Nasrallah ◽  
Anaïs Zulauf ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Salen Complexes ◽  
Heterogeneous Asymmetric Catalysis ◽  
Chiral Salen Complexes

scholarly journals An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations Under Anhydrous Conditions for DNA-Encoded Library Synthesis

2019 ◽  
Author(s):  
Yves Ruff ◽  
Roberto Martinez ◽  
Xavier Pellé ◽  
Pierre Nimsgern ◽  
Pascale Fille ◽  
...  
Keyword(s):  
Small Molecules ◽  
Organic Solvents ◽  
Cross Coupling ◽  
Amphiphilic Polymer ◽  
Aryl Halides ◽  
Chemical Transformations ◽  
Library Synthesis ◽  
Catch And Release ◽  
Dna Conjugates ◽  
Polymer Supported

Herein, we describe the development of a practical catch-and release methodology utilizing a cationic, amphiphilic PEG-based polymer to perform chemical transformations on immobilized DNA conjugates under anhydrous conditions. We demonstrate the usefulness of our APTAC (<u>a</u>mphiphilic <u>p</u>olymer-facilitated <u>t</u>ransformations under <u>a</u>nhydrous <u>c</u>onditions) approach by performing several challenging transformations on DNA-conjugated small molecules in pure organic solvents: the addition of a carbanion equivalent to a DNA-conjugated ketone in tetrahydrofuran, the synthesis of saturated heterocycles using the tin (Sn) amine protocol (SnAP) in dichloromethane and the dual-catalytic (Ir/Ni) metallaphotoredox decarboxylative cross-coupling of carboxylic acids to DNA-conjugated aryl halides in DMSO. In addition, we demonstrate the feasibility of the latter in multititer-plate format.

scholarly journals Polystyrene-Supported Acyclic Diaminocarbene Palladium Complexes in Sonogashira Cross-Coupling: Stability vs. Catalytic Activity

Catalysts ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 141 ◽  
Author(s):  
Vladimir Mikhaylov ◽  
Viktor Sorokoumov ◽  
Denis Liakhov ◽  
Alexander Tskhovrebov ◽  
Irina Balova
Keyword(s):  
Catalytic Activity ◽  
High Activity ◽  
Cross Coupling ◽  
Palladium Complexes ◽  
Lower Activity ◽  
Coupling Conditions ◽  
Acyclic Diaminocarbene ◽  
Supported Palladium ◽  
Polymer Supported

Two types of immobilized on the amino-functionalized polystyrene-supported acyclic diaminocarbene palladium complexes (ADC-PdII) are investigated under Sonogashira cross-coupling conditions. Depending on substituents in the diaminocarbene fragment immobilized ADC-PdII, systems are found to have different catalytic activity and stability regarding Pd-leaching. PdII-diaminocarbenes possessing protons at both nitrogen atoms smoothly decompose into Pd0-containing species providing a catalytic “cocktail system” with high activity and ability to reuse within nine runs. Polymer-supported palladium (II) complex bearing NBn–Ccarbene–NH-moiety exhibits greater stability while noticeably lower activity under Sonogashira cross-coupling. Four molecular ADC-PdII complexes are also synthesized and investigated with the aim of confirming proposed base-promoted pathway of ADC-PdII conversion through carbodiimide into an active Pd0 forms.

scholarly journals Asymmetric reactions in continuous flow

2009 ◽  
Vol 5 ◽  
Author(s):  
Xiao Yin Mak ◽  
Paola Laurino ◽  
Peter H Seeberger
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Catalysis ◽  
Continuous Flow ◽  
Asymmetric Reactions ◽  
Heterogeneous Asymmetric Catalysis

An overview of asymmetric synthesis in continuous flow and microreactors is presented in this review. Applications of homogeneous and heterogeneous asymmetric catalysis as well as biocatalysis in flow are discussed.

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