A facile approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives via a three-component domino reaction

2015 ◽  
Vol 13 (35) ◽  
pp. 9181-9185 ◽  
Author(s):  
Yuvaraj Dommaraju ◽  
Shruti Bora ◽  
Dipak Prajapati
Keyword(s):  
Aromatic Aldehyde ◽  
Domino Reaction ◽  
Pyrimidine Derivatives ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
First Time

A concise and efficient approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been accomplished for the first-time by a three-component reaction involving alkylsulfonyl acetonitrile, an aromatic aldehyde, and 6-aminouracil.

scholarly journals Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction

2019 ◽  
Vol 15 ◽  
pp. 874-880
Author(s):  
Razieh Navari ◽  
Saeed Balalaie ◽  
Saber Mehrparvar ◽  
Fatemeh Darvish ◽  
Frank Rominger ◽  
...  
Keyword(s):  
Room Temperature ◽  
High Selectivity ◽  
Domino Reaction ◽  
Primary Amines ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
High Yields

An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.

scholarly journals One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous Media

2010 ◽  
Vol 7 (3) ◽  
pp. 779-784 ◽  
Author(s):  
Sheng-Hui Li ◽  
Yan-Hong Shen ◽  
Na Gao ◽  
Ji-Tai Li
Keyword(s):  
Aromatic Aldehyde ◽  
Sodium Lauryl Sulfate ◽  
Aqueous Media ◽  
Lauryl Sulfate ◽  
Pyrimidine Derivatives ◽  
Reaction Conditions ◽  
One Pot ◽  
Environmental Friendly ◽  
Three Component Reaction ◽  
Work Up

A series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three-component reaction of aromatic aldehyde, malononitrile and 6-amino-4-hydroxy-2-mercaptopyrimidine catalyzed by sodium lauryl sulfate (SDS) in aqueous media. It was interesting that further aromatization took place automatically. This method provides several advantages such as easier work-up, milder reaction conditions and environmental friendly.

scholarly journals Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2835 ◽  
Author(s):  
Wei Lin ◽  
Cangwei Zhuang ◽  
Xiuxiu Hu ◽  
Juanjuan Zhang ◽  
Juxian Wang
Keyword(s):  
Sulfuric Acid ◽  
Domino Reaction ◽  
Coumarin Derivatives ◽  
Silica Sulfuric Acid ◽  
One Pot ◽  
Short Reaction Time ◽  
Three Component Reaction ◽  
Key Features ◽  
High Yields ◽  
First Time

A concise and efficient approach to synthesizing coumarin-fused pyrazolo[3,4-b]pyridine via silica sulfuric acid (SSA) catalyzed three-component domino reaction under microwave irradiation has been demonstrated. Participation of various alcohols in construction of coumarin derivatives has been described for the first time. Short reaction time, high yields, one-pot procedure, usage of eco-friendly catalyst, and solvent are the key features of this method.

Nucleophilic Phosphine-Promoted Domino Reaction of Dialkyl Acetylenedicarboxylates and 3-Arylamino-1-methyl-1H-pyrrole-2,5-diones

Synthesis ◽  
2018 ◽  
Vol 50 (18) ◽  
pp. 3715-3722 ◽  
Author(s):  
Ying Han ◽  
Chao-Guo Yan ◽  
Chang-Zhou Liu ◽  
Yuan-Yuan Zhang ◽  
Jing Sun
Keyword(s):  
Room Temperature ◽  
Domino Reaction ◽  
Dimethyl Acetylenedicarboxylate ◽  
Dialkyl Acetylenedicarboxylates ◽  
Three Component Reaction

The three-component reaction of triphenylphosphine, dimethyl acetylenedicarboxylate and 3-arylamino-1-methyl-1H-pyrrole-2,5-diones in CH2Cl2 at room temperature resulted in functionalized 3-(triphenyl-λ5-phosphanylidene)succinates in nearly quantitative yields. However, tri(n-butyl)phosphine promoted reaction of dialkyl acetylenedicarboxylates and 3-arylamino-1-methyl-1H-pyrrole-2,5-diones in CH2Cl2 afforded functionalized pyrrolo[3,4-b]pyridine-4-carboxylates in satisfactory yields.

Sustainable Passerini-tetrazole three component reaction (PT-3CR): selective synthesis of oxaborol-tetrazoles

2021 ◽  
Vol 57 (76) ◽  
pp. 9708-9711
Author(s):  
Akansha Singh ◽  
Ravindra Kumar
Keyword(s):  
Solvent Free ◽  
Selective Synthesis ◽  
Three Component Reaction ◽  
First Time

A sustainable catalyst- and solvent-free Passerini-tetrazole three component reaction (PT-3CR) has been developed for the selective synthesis of benzoxaborol-tetrazoles for the first time.

Synthesis of New Methano[1,5]dioxocines via a Domino Reaction of 4-Hydroxy-2H-pyran-2-ones / 4-Hydroxy-2H-chromen-2-ones with Acyclic 1,3-Diketones

2008 ◽  
Vol 63 (7) ◽  
pp. 871-876 ◽  
Author(s):  
Heiko Leutbecher ◽  
Jürgen Conrad ◽  
Uwe Beifus
Keyword(s):  
Domino Reaction ◽  
Three Component Reaction ◽  
Troger's Base

New methano[1,5]dioxocines, O-heterocycles with a framework similar to Tröger’s base, were prepared by means of a three-component reaction. The scope of this domino reaction was studied.

PTSA-Catalyzed One Pot Domino Synthesis of Dihydropyrido[2,3-d]pyrimidine Derivatives and their Antimicrobial Activity

2021 ◽  
Vol 6 (3) ◽  
pp. 222-227
Author(s):  
Krishna A. Bhensdadia ◽  
Prakash L. Kalavadiya ◽  
Nilam H. Lalavani ◽  
Shipra H. Baluja
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
In Vitro Antimicrobial Activity ◽  
Aryl Aldehydes ◽  
Three Component Reaction ◽  
The One

A novel series of dihydropyrido[2,3-d]pyrimidine derivatives were synthesized by multicomponent domino cyclization via the one-pot three component reaction of 6-amino uracil, substituted aryl aldehydes and N-methyl-1-(methylthio)-2-nitroethenamine in the presence of PTSA 10 mol% as a catalyst. The structures of these synthesized compounds were characterized by spectral analysis. Further the synthesized compounds screened for in vitro antimicrobial activity. Among all the compounds, compound 4b containing flouro substitution exhibited good inhibition against the tested species.

scholarly journals Conditional symmetries and exact solutions of a nonlinear three-component reaction-diffusion model

2020 ◽  
pp. 1-21
Author(s):  
R. M. CHERNIHA ◽  
V. V. DAVYDOVYCH
Keyword(s):  
Asymptotic Behaviour ◽  
Exact Solutions ◽  
Reaction Diffusion ◽  
Hunter Gatherers ◽  
Classical Symmetry ◽  
Classical Symmetries ◽  
Reaction Diffusion Model ◽  
Three Component Reaction ◽  
Biological Interpretation ◽  
First Time

Abstract Q-conditional (non-classical) symmetries of the known three-component reaction-diffusion (RD) system [K. Aoki et al. Theor. Popul. Biol. 50, 1–17 (1996)] modelling interaction between farmers and hunter-gatherers are constructed for the first time. A wide variety of Q-conditional symmetries are found, and it is shown that these symmetries are not equivalent to the Lie symmetries. Some operators of Q-conditional (non-classical) symmetry are applied for finding exact solutions of the RD system in question. Properties of the exact solutions (in particular, their asymptotic behaviour) are identified and possible biological interpretation is discussed.

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