Solute—Solvent Interactions Examined by the Nuclear Overhauser Effect

ChemInform ◽  
2007 ◽  
Vol 38 (37) ◽  
Author(s):  
J. T. Gerig
Keyword(s):  
Nuclear Overhauser Effect ◽  
Solvent Interactions ◽  
Overhauser Effect ◽  
Nuclear Overhauser

Applications of the intermolecular nuclear Overhauser effect. II. The operation of solute-site factors in the interaction of polar solutes with the solvent benzene

1983 ◽  
Vol 36 (11) ◽  
pp. 2227 ◽  
Author(s):  
GR Smith ◽  
B Ternai
Keyword(s):  
Nuclear Overhauser Effect ◽  
Proton Relaxation ◽  
Relaxation Rates ◽  
Site Factors ◽  
Aromatic Solvent ◽  
Proton Proton ◽  
Solvent Interactions ◽  
Overhauser Effect ◽  
Polar Solutes ◽  
Nuclear Overhauser

By considering the technique involving the measurement of aromatic solvent-induced shifts, and the models which have been proposed from the results of such measurements, it is suggested that the use of the solvent-induced solute proton intermolecular relaxation rate [(1/T1)solvinter] is a better method to study local solvation of solute molecules. Proton relaxation rates obtained for simple solutes in the solvent benzene are analysed in terms of an interaction parameter I, which treats (1/T1)solvinter] in terms of a proton-proton pair distribution function. The resultant dependence between I and a calculated measure of the local polarity of the observed solute is discussed in terms of previously proposed models of solute-solvent interactions.

1H NMR studies of [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in dimethylsulfoxide by nuclear Overhauser effect (NOE) enhancement spectroscopy: cis-trans Isomerism of the His-Pro bond

1990 ◽  
Vol 55 (4) ◽  
pp. 1106-1111 ◽  
Author(s):  
John Matsoukas ◽  
Paul Cordopatis ◽  
Raghav Yamdagni ◽  
Graham J. Moore
Keyword(s):  
1H Nmr ◽  
Nuclear Overhauser Effect ◽  
Nmr Studies ◽  
Restricted Rotation ◽  
Overhauser Effect ◽  
Major Isomer ◽  
Conformational Properties ◽  
Nuclear Overhauser

The conformational properties of the Sarmesin analogues [N-MeAib1, Tyr(Me)4]ANGII and [N-MeAib1, Tyr(Me)4, Ile8]ANGII in hexadeutero-dimethysulfoxide were investigated by Nuclear Overhauser Effect (NOE) Enhancement Studies. Cis-trans isomers (ratio 1 : 6) due to restricted rotation of the His-Pro bond were observed. Interresidue interactions between the His Cα proton and the two Pro Cδ protons revealed that the major isomer was the trans.

scholarly journals Cylindromicin from Arctic-Derived Fungus Tolypocladium sp. SCSIO 40433

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1080
Author(s):  
Imran Khan ◽  
Jing Peng ◽  
Zhuangjie Fang ◽  
Wei Liu ◽  
Wenjun Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Nuclear Overhauser Effect ◽  
Inhibition Activity ◽  
Tyrosinase Inhibition ◽  
Bioactive Natural Products ◽  
Chemical Structures ◽  
Overhauser Effect ◽  
Spectroscopic Analyses ◽  
Potential Resource ◽  
Nuclear Overhauser

The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2–8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.

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