Synthesis and in vivo Antihyperglycemic Activity of Nature-Mimicking Furanyl-2-pyranones in STZ-S Model.

ChemInform ◽  
2007 ◽  
Vol 38 (36) ◽  
Author(s):  
Fateh V. Singh ◽  
Sumit Chaurasia ◽  
Maya D. Joshi ◽  
Arvind K. Srivastava ◽  
Atul Goel
Keyword(s):  
Antihyperglycemic Activity ◽  
S Model

Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model

2007 ◽  
Vol 17 (9) ◽  
pp. 2425-2429 ◽  
Author(s):  
Fateh V. Singh ◽  
Sumit Chaurasia ◽  
Maya D. Joshi ◽  
Arvind K. Srivastava ◽  
Atul Goel
Keyword(s):  
Antihyperglycemic Activity ◽  
S Model

Phytochemical Screening, In-vitro and In-vivo Anti-diabetic Activity of Nelumbo nucifera Leaves against Alloxan-Induced Diabetic Rabbits

2019 ◽  
Author(s):  
Shahid Maqbool ◽  
Najeeb Ullah ◽  
Aqal Zaman ◽  
Atif Akbar ◽  
Saima Saeed ◽  
...  
Keyword(s):  
Body Weight ◽  
Quantitative Analysis ◽  
Cold Water ◽  
Nelumbo Nucifera ◽  
Plant Leaves ◽  
Standard Drug ◽  
Antihyperglycemic Activity ◽  
Butanol Fraction

A recent survey has demonstrated that traditional healers and herbalists frequently use Nelumbo nucifera plant to treat diabetes. The plant investigated here has been previously reported as natural folk medicine, but until now no scientific investigation of potential anti-diabetic effects have been reported. Plant leaves of Nelumbo nucifera were screened out for quantitative analysis of phytochemicals, in-vitro anti-diabetic activity (Alpha-amylase inhibitory assay) and In-vivo anti-diabetic assay of animals (rabbits). Quantitative analysis indicates that different phytochemicals were present in plant leaves extract/fractions. In-vitro antidiabetic analysis results poses that butanol fraction is significantly more active than other fractions or extract in antihyperglycemic activity with minimum IC50 value of 8.56µg/ml. For In-vivo anti-diabetic assay, animals (rabbits) were examined and animals were divided into 10 groups and except blank group all were treated with standard and plant extracts/fractions doses (25mg and 50mg per Kg body weight) as an aqueous suspension. Their blood sugar level was thoroughly recorded with a glucometer before the administration of sample and standard drug. Alloxan Monohydrate was administrated orally (as an ice-cold water solution) at dose rate 150mg/kg body weight for one week to make animals hyperglycemic. In-vivo analysis indicates that butanol fraction is the most active fraction in antihyperglycemic activity. So Leaves of N. nucifera can be used as antidiabetic remedy. So, it is strongly recommended that N. nucifera leaves should be elucidated further for isolation of active phytochemicals.

Synthesis of α-amyrin derivatives and their in vivo antihyperglycemic activity☆

2009 ◽  
Vol 44 (3) ◽  
pp. 1215-1222 ◽  
Author(s):  
T. Narender ◽  
T. Khaliq ◽  
A.B. Singh ◽  
M.D. Joshi ◽  
P. Mishra ◽  
...  
Keyword(s):  
Antihyperglycemic Activity

Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles

2005 ◽  
Vol 15 (8) ◽  
pp. 2115-2117 ◽  
Author(s):  
Ashoke Sharon ◽  
Ramendra Pratap ◽  
Priti Tiwari ◽  
Arvind Srivastava ◽  
P.R. Maulik ◽  
...  
Keyword(s):  
Antihyperglycemic Activity

scholarly journals A proposed lectin‐mediated mechanism to explain the in Vivo antihyperglycemic activity of γ‐conglutin from Lupinus albus seeds

2021 ◽  
Author(s):  
Madalena Grácio ◽  
João Rocha ◽  
Rui Pinto ◽  
Ricardo Boavida Ferreira ◽  
João Solas ◽  
...  
Keyword(s):  
Lupinus Albus ◽  
Antihyperglycemic Activity
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