Applied Suzuki Cross-Coupling Reaction for the Syntheses of Biologically Active Compounds

ChemInform ◽  
2006 ◽  
Vol 37 (36) ◽  
Author(s):  
V. M. Dembitsky ◽  
H. Abu Ali ◽  
M. Srebnik
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Cross Coupling Reaction

scholarly journals Metal Catalyzed Suzuki-Miyaura Cross-Coupling– Efficient Methodology for Synthesis the Natural and non-Natural biological active Molecules

2017 ◽  
Author(s):  
Hira Israr ◽  
Shazia Kaousar ◽  
Nasir Rasool ◽  
Gulraiz Ahmad ◽  
Muhammad Nazirul Mubin Aziz ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Transition Metal ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Biologically Active ◽  
Polymer Chemistry ◽  
Active Compounds ◽  
New Class ◽  
Cross Coupling Reaction ◽  
Metal Catalyzed

New class of biologically active and non-active compounds can be synthesized via transition metal mediated Suzuki cross coupling reaction that has a great impact on the advancement of organic chemistry. These resulted products can lend a helping hand in pharmaceutical and polymer chemistry for the betterment of mankind. Suzuki-Miyaura cross coupling reaction is one of the best tools through which many natural and non-natural compounds can be synthesized.

Copper-Catalyzed C–S Cross-Coupling Reaction: S-Arylation of Arylthioureas

Synthesis ◽  
2017 ◽  
Vol 49 (23) ◽  
pp. 5211-5216
Author(s):  
Hui Zhu ◽  
Xing Liu ◽  
Cai-Zhu Chang ◽  
Zhi-Bing Dong
Keyword(s):  
Reaction Time ◽  
Good Yield ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Biologically Active ◽  
Active Compounds ◽  
Short Reaction Time ◽  
Cross Coupling Reaction ◽  
Ligand Free ◽  
Convenient Preparation

A simple and efficient copper-catalyzed S-arylation of aryl­thioureas was developed. Arylthioureas were smoothly converted into aryl-isothioureas with good yield by copper-catalyzed S-arylation. The features of this method include the use of a ligand-free catalyst, good yield, short reaction time, and broad substrate scope. The method provides a facile and convenient preparation of some potentially biologically active compounds.

scholarly journals Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Masakazu Nambo ◽  
Jacky C.-H. Yim ◽  
Luiza B. O. Freitas ◽  
Yasuyo Tahara ◽  
Zachary T. Ariki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Late Stage ◽  
Recent Progress ◽  
Cross Coupling ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Arylboronic Acids ◽  
Modular Synthesis ◽  
Synthetic Routes

Abstract α-Fluoromethylarenes are common substructures in pharmaceuticals and agrochemicals, with the introduction of fluorine often resulting in improved biological activity and stability. Despite recent progress, synthetic routes to α-fluorinated diarylmethanes are still rare. Herein we describe the Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diarylmethanes. The ease of synthesis of fluorinated triflones as the key starting materials enables powerful late-stage transformations of known biologically active compounds into fluorinated analogs.

Chemoselective reactions: Toward the synthesis of biologically active natural products with anticancer activities

2008 ◽  
Vol 80 (8) ◽  
pp. 1683-1691 ◽  
Author(s):  
Sébastien Reymond ◽  
Laurent Ferrié ◽  
Amandine Guérinot ◽  
Patrice Capdevielle ◽  
Janine Cossy
Keyword(s):  
Natural Products ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Biologically Active ◽  
Synthetic Approach ◽  
Anticancer Activities ◽  
Leucascandrolide A ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed ◽  
Active Natural

Leucascandrolide A and migrastatin were synthesized efficiently by using chemoselective reactions such as olefin metatheses. The use of an iron-catalyzed cross-coupling reaction overcame difficulties encountered with palladium-catalyzed processes in our synthetic approach toward spirangien A.

scholarly journals Suzuki-Type Cross-Coupling Reaction of Unprotected 3-Iodoindazoles with Pinacol Vinyl Boronate: An Expeditive C-3 Vinylation of Indazoles under Microwave Irradiation

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2051 ◽  
Author(s):  
Gonzalo Vera ◽  
Benjamín Diethelm ◽  
Claudio Terraza ◽  
Gonzalo Recabarren-Gajardo
Keyword(s):  
Microwave Irradiation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Biologically Active ◽  
Cross Coupling Reaction ◽  
Synthetic Intermediates

Herein we report an expeditive C-3 vinylation of unprotected 3-iodoindazoles under microwave irradiation. Ten C-5 substituted 3-vinylindazole derivatives, nine of them novel, were synthesized through this method, which proceeds in moderate to excellent yields starting from C-5 substituted 3-iodoindazole derivatives. In all cases, the C-3 vinylated derivative was the only isolated product. This methodology allows access to 3-vinylated indazoles selectively and directly without the need of N-protection. 3-Vinylindazoles could be interesting synthetic intermediates allowing access to biologically active molecules.

Access to 2-substituted-2H-indazoles via a copper-catalyzed regioselective cross-coupling reaction

2018 ◽  
Vol 16 (11) ◽  
pp. 1816-1822 ◽  
Author(s):  
Rong Zhang ◽  
Zheng Liu ◽  
Qiujun Peng ◽  
Yijun Zhou ◽  
Lanting Xu ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Biologically Active ◽  
Hypervalent Iodine ◽  
Cross Coupling Reaction

A copper-catalyzed C–N cross-coupling reaction using commercially available 1H-indazoles with hypervalent iodine reagents to afford biologically active 2-substituted-2H-indazole is described.

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