Pd-Catalyzed Stereoselective Oxidation of Methyl Groups by Inexpensive Oxidants under Mild Conditions: A Dual Role for Carboxylic Anhydrides in Catalytic C—H Bond Oxidation.

ChemInform ◽  
2006 ◽  
Vol 37 (12) ◽  
Author(s):  
Ramesh Giri ◽  
Jue Liang ◽  
Jian-Guang Lei ◽  
Jiao-Jie Li ◽  
Dong-Hui Wang ◽  
...  
Keyword(s):  
Dual Role ◽  
Methyl Groups ◽  
Mild Conditions ◽  
Stereoselective Oxidation

Pd-Catalyzed Stereoselective Oxidation of Methyl Groups by Inexpensive Oxidants under Mild Conditions: A Dual Role for Carboxylic Anhydrides in Catalytic CH Bond Oxidation

2005 ◽  
Vol 117 (45) ◽  
pp. 7586-7590 ◽  
Author(s):  
Ramesh Giri ◽  
Jue Liang ◽  
Jian-Guang Lei ◽  
Jiao-Jie Li ◽  
Dong-Hui Wang ◽  
...  
Keyword(s):  
Dual Role ◽  
Methyl Groups ◽  
Mild Conditions ◽  
Stereoselective Oxidation

One-pot synthesis of novel N,N-bis(isoxazol-5-yl)methyl tertiary arylamines via sequential diprop-3-ynylation and 1,3-dipolar cycloaddition from primary amines

2019 ◽  
Vol 43 (9-10) ◽  
pp. 407-411 ◽  
Author(s):  
Xiao-Lan Zhang ◽  
Mei-Hong Wei ◽  
Shou-Ri Sheng ◽  
Xiao-Ling Liu
Keyword(s):  
Primary Amines ◽  
Dipolar Cycloaddition ◽  
Calcium Hydride ◽  
Methyl Groups ◽  
Propargyl Bromide ◽  
One Pot ◽  
Mild Conditions ◽  
Good Product ◽  
Easy Operation

A simple and efficient one-pot multicomponent approach for the synthesis of tertiary arylamines bearing N,N-bis(isoxazol-5-yl)methyl groups is developed through reactions including sequential diprop-3-ynylation of primary amines with propargyl bromide in the presence of calcium hydride in N,N-dimethylformamide, and 1,3-dipolar cycloaddition with nitrile oxides generated in situ from hydroximyl chlorides in DMF-Et3N. This protocol provides advantages such as high regioselectivity, easy operation, and moderate-to-good product yields with a wide substrate scope under mild conditions.

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

2021 ◽  
Vol 19 (1) ◽  
pp. 156-161
Author(s):  
Silvia Anselmi ◽  
Siyu Liu ◽  
Seong-Heun Kim ◽  
Sarah M. Barry ◽  
Thomas S. Moody ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Dual Role ◽  
Mild Conditions ◽  
Urea Hydrogen Peroxide ◽  
Role Of Solvent

Sulfoxides have been synthesised from various sulfide substrates under mild conditions exploiting CALB biocatalyst in the presence of urea hydrogen peroxide and AcOEt which acts with the dual role of solvent and reagent.

Direct Transformation of Cyano into Methyl Groups under Mild Conditions

Synthesis ◽  
1982 ◽  
Vol 1982 (12) ◽  
pp. 1036-1037 ◽  
Author(s):  
George R. Brown ◽  
Alan J. Foubister
Keyword(s):  
Methyl Groups ◽  
Direct Transformation ◽  
Mild Conditions

Copper-Catalyzed Oxidative Synthesis of α-Ketoamides from Aryl Methyl Ketones and N-Bromobutanimide Using N,N-Dimethylformamide as Dimethylamine Source

Synlett ◽  
2020 ◽  
Vol 31 (04) ◽  
pp. 393-397 ◽  
Author(s):  
Ying Wei ◽  
Yongxia Yan ◽  
Xiaoyan Li
Keyword(s):  
Acid Hydrolysis ◽  
Dual Role ◽  
Methyl Ketones ◽  
Mechanistic Studies ◽  
Mild Conditions ◽  
Aryl Methyl

A novel and practical Cu(OAc)2-catalyzed oxidative synthesis of α-ketoamides from aryl methyl ketones and N-bromobutanimide (NBS) using N,N-dimethylformamide (DMF) as dimethylamine (HNMe2) source and solvent has been developed under mild conditions. DMF was used as a HNMe2 source and can be easily converted into HNMe2 by acid hydrolysis. The mechanistic studies indicate that Cu(OAc)2 plays a dual role in providing both catalyst and oxidant.

scholarly journals Efficient preparation of carbamates by Rh-catalysed oxidative carbonylation: unveiling the role of the oxidant

2017 ◽  
Vol 53 (2) ◽  
pp. 404-407 ◽  
Author(s):  
Amaia Iturmendi ◽  
Manuel Iglesias ◽  
Julen Munárriz ◽  
Victor Polo ◽  
Jesús J. Pérez-Torrente ◽  
...  
Keyword(s):  
Dual Role ◽  
Oxidative Carbonylation ◽  
Mild Conditions ◽  
Three Component Reaction

A Rh(i)-catalysed three-component reaction allows access to carbamates from amines or imines under mild conditions in the presence of Oxone, which plays a dual role as a base and an oxidant.

scholarly journals A Zinc-Mediated Deprotective Annulation Approach to New Polycyclic Heterocycles

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2318
Author(s):  
Lucia Veltri ◽  
Roberta Amuso ◽  
Marzia Petrilli ◽  
Corrado Cuocci ◽  
Maria A. Chiacchio ◽  
...  
Keyword(s):  
Diffraction Analysis ◽  
Triple Bond ◽  
Dual Role ◽  
Nucleophilic Attack ◽  
X Ray Diffraction ◽  
X Ray ◽  
Tert Butyl ◽  
Mild Conditions ◽  
Carbamate Group ◽  
Straightforward Approach

A straightforward approach to new polycyclic heterocycles, 1H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-ones, is presented. It is based on the ZnCl2-promoted deprotective 6-endo-dig heterocyclization of N-Boc-2-alkynylbenzimidazoles under mild conditions (CH2Cl2, 40 °C for 3 h). The zinc center plays a dual role, as it promotes Boc deprotection (with formation of the tert-butyl carbocation, which can be trapped by substrates bearing a nucleophilic group) and activates the triple bond toward intramolecular nucleophilic attack by the carbamate group. The structure of representative products has been confirmed by X-ray diffraction analysis.

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