Total Synthesis of Polycavernoside A (I), a Lethal Toxin of the Red Alga Polycavernosa tsudai.

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...  

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The total synthesis of the recently isolated bicyclic sesquiterpenoid drechslerine B (2), isolated from the algicolous fungus Drechslera dematioidearare in the marine red alga Liagora viscida, has been achieved, starting from ( S)-carvone (8), via an intramolecular aldol reaction and palladium-catalyzed carbon monoxide insertion as key reactions.


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Mari Yotsu-Yamashita ◽  
Robert L. Haddock ◽  
Takeshi Yasumoto

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