Synthesis and Biological Activity of Phencyclidine Homologues with para-Hydroxy-Group in the Aromatic Ring.

ChemInform ◽  
2005 ◽  
Vol 36 (34) ◽  
Author(s):  
V. A. Glushkov ◽  
L. V. Anikina ◽  
Yu. B. Vikharev ◽  
O. G. Stryapunina ◽  
Yu. V. Shklyaev ◽  
...  
Keyword(s):  
Biological Activity ◽  
Aromatic Ring ◽  
Hydroxy Group

scholarly journals Tandem MS-Based Metabolite Profiling of 19,20-Epoxycytochalasin C Reveals the Importance of a Hydroxy Group at the C7 Position for Biological Activity

ACS Omega ◽  
2021 ◽  
Vol 6 (5) ◽  
pp. 3717-3726
Author(s):  
Manoj Kushwaha ◽  
Arem Qayum ◽  
Shreyans K. Jain ◽  
Jasvinder Singh ◽  
Amit Kumar Srivastava ◽  
...  
Keyword(s):  
Biological Activity ◽  
Hydroxy Group ◽  
Metabolite Profiling ◽  
Tandem Ms

scholarly journals Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 57 ◽  
Author(s):  
Olga Ivanova ◽  
Vladimir Andronov ◽  
Irina Levina ◽  
Alexey Chagarovskiy ◽  
Leonid Voskressensky ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aromatic Ring ◽  
Hydroxy Group ◽  
Fine Chemicals ◽  
Simple Method ◽  
Convenient Synthesis ◽  
Donor Acceptor

A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring.

Synthesis and Biological Activity of New 16,17-Secoestrone Derivatives

2000 ◽  
Vol 65 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Suzana Jovanović-Šanta ◽  
Silvana Andrić ◽  
Radmila Kovačević ◽  
Vjera Pejanović
Keyword(s):  
Biological Activity ◽  
Hydroxy Group ◽  
Sodium Borohydride ◽  
Estrogenic Activity ◽  
Complete Loss ◽  
Borohydride Reduction ◽  
Experimental Animals ◽  
Biological Tests ◽  
Sodium Borohydride Reduction

Starting from estrone 3-benzyloxy-17β-hydroxyestra-1,3,5(10)-trien-16-one oxime (3b) was synthesized, which underwent Beckmann fragmentation giving the 3-benzyloxy-17-oxo- 16,17-secoestra-1,3,5(10)-triene-16-nitrile (4b). Sodium borohydride reduction of this compound afforded 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile (5b). The deprotection of the 3-hydroxy group was achieved by action of hydrogen upon derivatives 4b and 5b in presence of Pd/C as a catalyst, yielding 3-hydroxy-17-oxo-16,17-secoestra- 1,3,5(10)-triene-16-nitrile (4a) and 3,17-dihydroxy-16,17-secoestra-1,3,5(10)-triene-16-nitrile (5a). In biological tests on experimental animals, compounds 4a, 4b, 5a and 5b showed virtually a complete loss of estrogenic activity, whereas compounds 4a, 5a and 5b exhibited moderate antiestrogenic effect.

scholarly journals Selective Synthesis of Ortho-substituted 3-Cyclohexyl-2-phenyl-1,3-thiazolidin-4-one Sulfoxides and Sulfones by S-Oxidation with Oxone

2015 ◽  
Vol 7 (2) ◽  
pp. 73 ◽  
Author(s):  
Kevin Cannon ◽  
Deepa Gandla ◽  
Samantha Lauro ◽  
Lee Silverberg ◽  
John Tierney ◽  
...  
Keyword(s):  
Biological Activity ◽  
High Temperature ◽  
Aromatic Ring ◽  
Selective Oxidation ◽  
1H Nmr ◽  
Room Temperature ◽  
Selective Synthesis ◽  
Wide Range ◽  
Synthetic Routes ◽  
S Oxidation

1,3-thiazolidin-4-ones, also known as thiazolidin-4-ones, are known to have a very wide range of biological activity. The corresponding S-oxides may show enhanced activity, and therefore viable synthetic routes to these S-oxides are required. S-oxidation of 3-cyclohexyl-2-phenyl-1,3-thiazolidin-4-ones with Oxone® was investigated. For all compounds evaluated, selective oxidation to the sulfoxide was realized using 3 equivalents of Oxone® at room temperature. Alternatively, the sulfone was prepared selectively at high temperature by increasing the equivalents of Oxone® used; the extent of this selectivity was affected by the substituent of the aromatic ring. In those cases in which the reaction produced a mixture of the sulfoxide and sulfone, the ratio of the products was quantified by 1H NMR.

Magnesium and biological activity of oxytocin analogues modified on aromatic ring of amino acid in position 2

2001 ◽  
Vol 7 (8) ◽  
pp. 413-424 ◽  
Author(s):  
Jiřina Slaninová ◽  
Lenka Maletínská ◽  
Jiří Vondrášek ◽  
Zdenko Procházka
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Aromatic Ring
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