scholarly journals Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 57 ◽  
Author(s):  
Olga Ivanova ◽  
Vladimir Andronov ◽  
Irina Levina ◽  
Alexey Chagarovskiy ◽  
Leonid Voskressensky ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aromatic Ring ◽  
Hydroxy Group ◽  
Fine Chemicals ◽  
Simple Method ◽  
Convenient Synthesis ◽  
Donor Acceptor

A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring.

Evaluation of the Elbs Persulfate Oxidation Reaction for the Preparation of Aryloxyphenoxypropionate Herbicides

1995 ◽  
Vol 48 (8) ◽  
pp. 1503 ◽  
Author(s):  
KG Watson ◽  
A Serban
Keyword(s):  
Acetic Acid ◽  
Hydroxy Group ◽  
Good Yield ◽  
Oxidation Reaction ◽  
Aryl Halides ◽  
Simple Method ◽  
Free Hydroxy Group ◽  
Persulfate Oxidation ◽  
Mild Hydrolysis ◽  
Hydrolysis Of

A new, simple method for the preparation of several 4-( aryloxy )phenols (2a-d) and alkyl 2-(4-hydroxyphenoxy)propionates (3a,b) is described. These compounds are key precursors for the synthesis of important aryloxyphenoxypropionate herbicides (1a-d). The method uses the Elbs persulfate oxidation to convert phenol into 4-hydroxyphenyl sulfate (5). The free hydroxy group is then reacted with various aryl halides and alkyl 2-halopropionates. Mild hydrolysis of the sulfate group with boiling acetic acid then gives the products (2a-d) and (3a,b), generally in modest to good yield.

scholarly journals Visual inspection of cervix with acetic acid as a feasible screening test for cervical neoplasia among women attending at OPD in Rajshahi Medical College Hospital

KYAMC Journal ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. 56-60
Author(s):  
Nahid Yusuf ◽  
Md Ahmed Ali ◽  
Nazmun Nahar ◽  
Shipra Chaudhury ◽  
Md Zillur Rahman
Keyword(s):  
Acetic Acid ◽  
Predictive Value ◽  
Urban Areas ◽  
Visual Inspection ◽  
Pap Smear ◽  
Low Cost ◽  
Low Grade ◽  
College Hospital ◽  
Health Care Centre ◽  
Simple Method

Background: Visual inspection of cervix after application of 3-5% acetic acid (VIA) is a potential alternative to Pap smear cytology for screening of cervical cancer in resource poor settings.Objectives: This study was to evaluate the performance of visual inspection based screening approach in the detection of precancerous and early cancerous lesions of the cervix.Materials & Methods: VIA was carried out in 540 eligible women attending Gynae OPD. Detection of well-defined, opaque, acetowhite lesion close to squamocolumnar junction or in transitional zone of the cervix constituted positive VIA. All screened women evaluated by colposcopy and biopsy were taken from colposcopically suspected areas. The final diagnosis was based on histology.Results: Out of 540 patients, 328 were VIA negative and 212 were VIA positive. Colposcopy showed normal results in 340 cases, low grade CIN in 138 cases, high grade CIN in 44 cases and cancer in 18 cases. There were biopsy proven chronic cervicitis and metaplastic changes in 423 cases, CIN I in 66 cases, CIN II in 25 cases, CIN III / carcinoma-in-situ in 5 cases. The sensitivity of VIA was 74.36%, specificity 70.45%, positive predictive value 41.04%, & negative predictive value 90.85%.Conclusion: VIA can differentiate a normal cervix from a precancerous cervix with reasonable accuracy. As it is low cost and simple method, it can be set in any hospital or any health care centre of rural or urban areas of poor resource settings.KYAMC Journal Vol. 9, No.-2, July 2018, Page 56-60

The Reaction of 2-(Acylamino)benzonitriles with Primary Aromatic Amines: A Convenient Synthesis of 2-Substituted 4-(Arylamino)quinazolines

Synthesis ◽  
2015 ◽  
Vol 47 (11) ◽  
pp. 1623-1632 ◽  
Author(s):  
Elina Marinho ◽  
M. Proença
Keyword(s):  
Acetic Acid ◽  
Trifluoroacetic Acid ◽  
Aromatic Amines ◽  
Room Temperature ◽  
Ethyl Chloroformate ◽  
Convenient Synthesis ◽  
Primary Aromatic Amines

2-Substituted 4-(arylamino)quinazolines were prepared from 2-(acylamino)benzonitriles and primary arylamines by refluxing in either ethanol using trifluoroacetic acid as a catalyst or acetic acid. The 2-aminobenzonitrile was acylated by reaction with anhydrides, isocyanates, or ethyl chloroformate at room temperature.

Benzylic oxidation by sodium bismuthate in acetic acid: A simple method for the synthesis of polycyclic aromatic ketones

1998 ◽  
Vol 39 (40) ◽  
pp. 7247-7250 ◽  
Author(s):  
Bimal K. Banik ◽  
M.S. Venkatraman ◽  
Chhanda Mukhopadhyay ◽  
Frederick F. Becker
Keyword(s):  
Acetic Acid ◽  
Simple Method ◽  
Aromatic Ketones ◽  
Benzylic Oxidation ◽  
Polycyclic Aromatic ◽  
Sodium Bismuthate
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