Mixture-Based Combinatorial Libraries: from Peptides and Peptidomimetics to Small Molecule Acyclic and Heterocyclic Compounds

ChemInform ◽  
2005 ◽  
Vol 36 (1) ◽  
Author(s):  
Cornelia E. Hoesl ◽  
Adel Nefzi ◽  
John M. Ostresh ◽  
Yongping Yu ◽  
Richard A. Houghten
Keyword(s):  
Small Molecule ◽  
Heterocyclic Compounds ◽  
Combinatorial Libraries

scholarly journals Combinatorial Libraries of Bis-heterocyclic Compounds with Skeletal Diversity

2008 ◽  
Vol 10 (6) ◽  
pp. 923-933 ◽  
Author(s):  
Miroslav Soural ◽  
Isabelle Bouillon ◽  
Viktor Krchňák
Keyword(s):  
Heterocyclic Compounds ◽  
Combinatorial Libraries ◽  
Skeletal Diversity

Tetralone scaffolds and their potential therapeutic applications

2020 ◽  
Vol 17 ◽  
Author(s):  
Bhagwati Gauni ◽  
Krunal Mehariya ◽  
Anamik Shah ◽  
Srinivas Murty Duggirala
Keyword(s):  
Antitumor Activity ◽  
Organic Synthesis ◽  
Small Molecule ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Acetylcholinesterase Inhibitors ◽  
Building Blocks ◽  
Structural Features ◽  
Therapeutic Applications ◽  
Small Molecule Library

: Substituted tetralones have played a substantial role in organic synthesis due to their strong reactivity and suitability as a starting material for a range of synthetic heterocyclic compounds, pharmaceuticals along with biological activities as well as precursors of many natural products and their derivatives. Many α-tetralone derivatives are building blocks, that have been used in the synthesis of therapeutically functional compounds like some antibiotics, antidepressants, acetylcholinesterase inhibitors effective for treating Alzheimer’s disease and alkaloids possessing antitumor activity. In this review, there has been an attempt to explore the small molecule library having α-tetralone scaffold along with their diverse biological activities. Structural features of α-tetralone derivatives responsible for potential therapeutic applications are also described.

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