Solvent-Free Organic Syntheses

ChemInform ◽  
2004 ◽  
Vol 35 (28) ◽  
Author(s):  
Juergen O. Metzger
Keyword(s):  
Solvent Free ◽  
Organic Syntheses

Solvent-free organic syntheses

1999 ◽  
Vol 1 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Rajender S. Varma
Keyword(s):  
Solvent Free ◽  
Organic Syntheses

ChemInform Abstract: Solvent-Free Organic Syntheses

ChemInform ◽  
2010 ◽  
Vol 30 (11) ◽  
pp. no-no
Author(s):  
Juergen O. Metzger
Keyword(s):  
Solvent Free ◽  
Organic Syntheses

Solvent-free accelerated organic syntheses using microwaves

2001 ◽  
Vol 73 (1) ◽  
pp. 193-198 ◽  
Author(s):  
Rajender S. Varma
Keyword(s):  
Organic Synthesis ◽  
High Speed ◽  
Multicomponent Reactions ◽  
Solvent Free ◽  
Parallel Synthesis ◽  
One Pot ◽  
Reduction Reactions ◽  
Heterocyclic Molecules ◽  
Organic Syntheses

A solvent-free approach for organic synthesis is described which involves microwave (MW) exposure of neat reactants (undiluted) either in the presence of a catalyst or catalyzed by the surfaces of inexpensive and recyclable mineral supports such as alumina, silica, clay, or "doped" surfaces, namely, Fe(NO3)3-clay (clayfen), Cu(NO3)2-clay (claycop), NH2OH-clay, PhI(OAc)2-alumina, NaIO4-silica, MnO2-silica, and NaBH4-clay. A variety of deprotection, condensation, cyclization, oxidation, and reduction reactions are presented including the efficient one-pot assembly of heterocyclic molecules from in situ generated intermediates such as enamines and a-tosyloxyketones. The application of this solvent-free MW approach to multicomponent reactions is highlighted that can be adapted for high-speed parallel synthesis of the library of dihydropyrimidine-2(1H)-ones and imidazo [1,2-a]annulated pyridines, pyrazines, and pyrimidines.

ChemInform Abstract: Solvent-Free Organic Syntheses

ChemInform ◽  
2010 ◽  
Vol 30 (27) ◽  
pp. no-no
Author(s):  
Rajender S. Varma
Keyword(s):  
Solvent Free ◽  
Organic Syntheses
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