Tetrapetalone A, a Novel Lipoxygenase Inhibitor from Streptomyces sp.

Toshikazu Komoda; Yasumasa Sugiyama; Naoki Abe; Misako Imachi; Hiroshi Hirota; Akira Hirota

doi:10.1002/chin.200320234

Tetrapetalone A, a Novel Lipoxygenase Inhibitor from Streptomyces sp.

ChemInform ◽

10.1002/chin.200320234 ◽

2003 ◽

Vol 34 (20) ◽

Author(s):

Toshikazu Komoda ◽

Yasumasa Sugiyama ◽

Naoki Abe ◽

Misako Imachi ◽

Hiroshi Hirota ◽

...

Keyword(s):

Lipoxygenase Inhibitor ◽

Streptomyces Sp ◽

Tetrapetalone A

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Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.

Tetrahedron Letters ◽

10.1016/s0040-4039(03)00007-8 ◽

2003 ◽

Vol 44 (8) ◽

pp. 1659-1661 ◽

Cited By ~ 35

Author(s):

Toshikazu Komoda ◽

Yasumasa Sugiyama ◽

Naoki Abe ◽

Misako Imachi ◽

Hiroshi Hirota ◽

...

Keyword(s):

Lipoxygenase Inhibitor ◽

Streptomyces Sp ◽

Tetrapetalone A

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P3276 Cardioprotective effect of lipoxygenase inhibitor Quercetin in acute myocardial infarction with left-ventricular heart failure

European Heart Journal ◽

10.1016/s0195-668x(03)95902-1 ◽

2003 ◽

Vol 24 (5) ◽

pp. 620

Author(s):

S KOZHUKHOV

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Acute Myocardial Infarction ◽

Left Ventricular ◽

Cardioprotective Effect ◽

Lipoxygenase Inhibitor

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Structure determination and biosynthesis of the antifungal butyrolactols from Streptomyces sp.

Planta Medica ◽

10.1055/s-0036-1596637 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381 ◽

Cited By ~ 1

Author(s):

K Ko ◽

HM Ge ◽

J Shin ◽

DC Oh

Keyword(s):

Structure Determination ◽

Streptomyces Sp

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Platelet Aggregation in Whole Blood: The Role of Thromboxane A2 and Adenosine Diphosphate

Thrombosis and Haemostasis ◽

10.1055/s-0038-1660081 ◽

1985 ◽

Vol 54 (03) ◽

pp. 612-616 ◽

Cited By ~ 17

Author(s):

A J Carter ◽

S Heptinstall

Keyword(s):

Platelet Aggregation ◽

Whole Blood ◽

Adenosine Diphosphate ◽

Blood Platelet ◽

Thromboxane B2 ◽

Lipoxygenase Inhibitor ◽

Thromboxane Synthase Inhibitor ◽

Synthase Inhibitor

SummaryThe platelet aggregation that occurred in whole blood in response to several aggregating agents (collagen, arachidonic acid, adenosine diphosphate, adrenaline and thrombin) was measured using an Ultra-Flo 100 Whole Blood Platelet Counter. The amounts of thromboxane B2 produced were measured by radioimmunoassay. The effects of various inhibitors of thromboxane synthesis and the effects of apyrase, an enzyme that destroys adenosine diphosphate, were determined.Platelet aggregation was always accompanied by the production of thromboxane B2, and the amounts produced depended on the nature and concentration of the aggregating agent used. The various inhibitors of thromboxane synthesis - aspirin and flurbiprofen (cyclo-oxygenase inhibitors), BW755C (a cyclo-oxygenase and lipoxygenase inhibitor) and dazoxiben (a selective thromboxane synthase inhibitor) - did not markedly inhibit aggregation. Results obtained using apyrase showed that adenosine diphosphate contributed to the aggregation process, and that its role must be acknowledged when devising means of inhibiting platelet aggregation in vivo.

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