Treatment of hyperkeratotic skin diseases with R 68151, a topical 5-lipoxygenase inhibitor: four case reports

1992 ◽  
Vol 128 (7) ◽  
pp. 993-994 ◽  
Author(s):  
K. Marien
Keyword(s):  
Skin Diseases ◽  
Case Reports ◽  
Lipoxygenase Inhibitor

Autoimmune Bullous Skin Diseases Occurring under Anti-Tumor Necrosis Factor Therapy: Two Case Reports

Dermatology ◽  
2010 ◽  
Vol 221 (3) ◽  
pp. 201-205 ◽  
Author(s):  
L. Boussemart ◽  
S. Jacobelli ◽  
F. Batteux ◽  
C. Goulvestre ◽  
P. Grange ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Skin Diseases ◽  
Case Reports ◽  
Factor Therapy ◽  
Bullous Skin Diseases ◽  
Necrosis Factor

scholarly journals CUTANEOUS MICROABSCESSES BY MYCOBACTERIUM CHELONAE : CASE REPORTS FROM A TERTIARY CARE CENTRE, TRIPURA

2021 ◽  
Vol 9 (10) ◽  
pp. 713-716
Author(s):  
Sibabrata Bhattacharya ◽  
◽  
Ashmita Banik ◽  
Tapan Majumdar ◽  
Banti Das ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Subcutaneous Tissue ◽  
Case Reports ◽  
Tertiary Care ◽  
Mycobacterial Infection ◽  
Tertiary Care Centre ◽  
Mycobacterium Chelonae ◽  
First Case ◽  
Nontuberculous Mycobacterial Infection ◽  
History Of

Nontuberculous mycobacterial (NTM) infections are on the rise. They often cause skin diseases that are misdiagnosed.Two cases of Mycobacterium chelonae infection in immunocompetent patients were presented. First case showed infection of cutaneous and subcutaneous tissue without any preceeding history of skin injury by any intervention like trauma or injection, which was a rare manifestation. The second case showed M chelonae infection as a port site infection in a non healing ulcer. The history and clinical presentation of both the cases were documented. Treatment was also reported with subsequent output during further follow ups. Here both the cases showed resistance to commonly used amtimicrobial agents which increased the suspicion of nontuberculous mycobacterial infection among clinicians and microbiologist and made the diagnosis easier.

The Role of Psychological Stress in Skin Disease

2001 ◽  
Vol 5 (2) ◽  
pp. 140-145 ◽  
Author(s):  
Arash Kimyai-Asadi ◽  
Adil Usman
Keyword(s):  
Psychological Stress ◽  
Skin Disease ◽  
Basic Science ◽  
Skin Diseases ◽  
Case Reports ◽  
Numerous Case ◽  
Psychotherapeutic Interventions ◽  
Eczematous Dermatitis ◽  
Science Evidence

Background: Numerous case reports and studies have suggested that psychological stress may have a role in the onset or exacerbation of a variety of skin diseases. Objective: We review the literature pertaining to the role of psychological stress in the exacerbation of psoriasis, urticaria, eczematous dermatitis, herpesvirus infections, and other skin diseases; discuss potential mechanisms of stress-induced skin disease; and review studies and case reports of psychotherapeutic interventions that have been found helpful in the therapy of skin diseases. Conclusions: There is evidence linking psychological stress to exacerbation of certain skin diseases. Both the clinical and the basic science evidence, however, can be hard to interpret in light of the difficulty of defining and quantifying psychological stress as well as the questions regarding the etiologic significance of neuroimmunologic findings in skin diseases.

scholarly journals Clinical Application of Development of Nonantibiotic Macrolides That Correct Inflammation-Driven Immune Dysfunction in Inflammatory Skin Diseases

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Carmen Rodriguez-Cerdeira ◽  
Elena Sanchez-Blanco ◽  
Alberto Molares-Vila
Keyword(s):  
Lupus Erythematosus ◽  
Skin Diseases ◽  
Case Reports ◽  
Immune Dysfunction ◽  
Neutrophilic Dermatosis ◽  
Immunomodulatory Activity ◽  
Activated T Cells ◽  
Inflammatory Skin Diseases ◽  
Autoimmune Urticaria ◽  
Anti Inflammatory

Background. Inflammation-driven immune dysfunction supports the development of several chronic human disorders including skin diseases. Nonantibiotic macrolides have anti-inflammatory and/or immunomodulatory activity that suggests the exploitation of these in the treatment of skin diseases characterized by inflammatory disorders.Materials and Methods. We performed an extensive review of the nonantibiotic macrolide literature published between 2005 and 2012, including cross-references of any retrieved articles. We also included some data from our own experience.Results. Calcineurin antagonists such as tacrolimus and ascomycins (e.g., pimecrolimus) act by inhibiting the activation of the nuclear factor for activated T cells (NFAT). There are new applications for these macrolides that have been available for several years and have been applied to skin and hair disorders such as atopic dermatitis, oral lichen planus, vitiligo, chronic autoimmune urticaria, rosacea, alopecia areata, pyoderma gangrenosum, Behcet’s disease, neutrophilic dermatosis, and lupus erythematosus. We also reviewed new macrolides, like rapamycin, everolimus, and temsirolimus. In addition to the literature review, we report a novel class of nonantibiotic 14-member macrocycle with anti-inflammatory and immunomodulatory effects.Conclusions. This paper summarizes the most important clinical studies and case reports dealing with the potential benefits of nonantibiotic macrolides which have opened new avenues in the development of anti-inflammatory strategies in the treatment of cutaneous disorders.

scholarly journals Immunocompromised Districts of Skin: A Case Series and a Literature Review

2019 ◽  
Vol 7 (18) ◽  
pp. 2969-2975 ◽  
Author(s):  
Aleksandra Vojvodic ◽  
Michael Tirant ◽  
Veronica Di Nardo ◽  
Torello Lotti ◽  
Uwe Wollina
Keyword(s):  
Literature Review ◽  
Skin Diseases ◽  
Case Reports ◽  
Case Series ◽  
Skin Disorders

BACKGROUND: The concept of immunocompromised districts of skin has been developed by Ruocco and helps to explain certain aspects of the macromorphology of skin diseases. This concept unites the isomorphic response of Koebner and the isotopic response of Wolf. CASE REPORTS: We present different cutaneous conditions which can lead to immunocompromised districts of skin such as scars, radiodermatitis, lymphedema, disturbed innervation or mechanical friction etc. Typical and rarer skin disorders associated with them are discussed and illustrated by their observations. CONCLUSION: At this moment, we wish to inform dermatologists and non-dermatologists about Ruocco’s concept and its implications.  

scholarly journals Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1436
Author(s):  
Karina Polak ◽  
Antal Jobbágy ◽  
Tomasz Muszyński ◽  
Kamila Wojciechowska ◽  
Aleksandra Frątczak ◽  
...  
Keyword(s):  
Therapeutic Approach ◽  
Skin Diseases ◽  
Ex Vivo ◽  
Case Reports ◽  
Seborrheic Dermatitis ◽  
Final Analysis ◽  
Research Attention ◽  
Microbiome Composition ◽  
Chronic Skin ◽  
Chronic Skin Diseases

There is a growing quantity of evidence on how skin and gut microbiome composition impacts the course of various dermatological diseases. The strategies involving the modulation of bacterial composition are increasingly in the focus of research attention. The aim of the present review was to analyze the literature available in PubMed (MEDLINE) and EMBASE databases on the topic of microbiome modulation in skin diseases. The effects and possible mechanisms of action of probiotics, prebiotics and synbiotics in dermatological conditions including atopic dermatitis (AD), psoriasis, chronic ulcers, seborrheic dermatitis, burns and acne were analyzed. Due to the very limited number of studies available regarding the topic of microbiome modulation in all skin diseases except for AD, the authors decided to also include case reports and original studies concerning oral administration and topical application of the pro-, pre- and synbiotics in the final analysis. The evaluated studies mostly reported significant health benefits to the patients or show promising results in animal or ex vivo studies. However, due to a limited amount of research and unambiguous results, the topic of microbiome modulation as a therapeutic approach in skin diseases still warrants further investigation.

scholarly journals Impact of Psoriasis and Hidradenitis Suppurativa in Pregnancy, a Systematic Review

2021 ◽  
Vol 10 (24) ◽  
pp. 5894
Author(s):  
Maria-Angeles Ferrer-Alcala ◽  
Manuel Sánchez-Díaz ◽  
Salvador Arias-Santiago ◽  
Alejandro Molina-Leyva
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Hidradenitis Suppurativa ◽  
Skin Diseases ◽  
Case Reports ◽  
Scientific Evidence ◽  
Acne Inversa ◽  
Inflammatory Skin Diseases ◽  
Search Terms ◽  
The Impact

Psoriasis and hidradenitis suppurativa (HS) are chronic inflammatory skin diseases that frequently develop in young women. The aim of this study is to evaluate how hidradenitis suppurativa and psoriasis impact women desiring to conceive, and their influence on fertility and gestation. A systematic review of articles dating from January 2015 to April 2021 was performed using the Scopus (Elsevier) database. The search terms were (psoriasis and (birth or pregnancy or fertility)) and ((hidradenitis suppurativa or acne inversa) and (birth or pregnancy or fertility)). The search was limited to human data. Systematic reviews, case reports, clinical practice guidelines, expert consensus and conference papers were excluded. The impact of HS on pregnancy includes an impaired desire for pregnancy, a decrease in fertility, the worsening of the disease during pregnancy and potential adverse events during pregnancy. Moreover, the pregnancy might imply a change on the treatment of HS. The impact of psoriasis on pregnancy includes a decrease in fertility, potential adverse events during pregnancy and an unpredictable evolution of the disease. Moreover, the pregnancy might imply a change on the treatment of psoriasis, although biologic therapies do not appear to increase the risk of adverse events. In conclusion, both HS and psoriasis have an impact on pregnancy. A decrease of fertility has been reported. Moreover, both diseases have an unpredictable evolution during pregnancy. Pregnant women who are under biologic therapy do not seem to have a higher rate of adverse events. Treatment of both conditions is usually halted during pregnancy since scientific evidence about their safety is not conclusive, or teratogenic risk has been proven.

scholarly journals The Skin in Celiac Disease Patients: The Other Side of the Coin

Medicina ◽  
2019 ◽  
Vol 55 (9) ◽  
pp. 578 ◽  
Author(s):  
Ludovico Abenavoli ◽  
Stefano Dastoli ◽  
Luigi Bennardo ◽  
Luigi Boccuto ◽  
Maria Passante ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Celiac Disease ◽  
Skin Diseases ◽  
Case Reports ◽  
Case Series ◽  
The Other ◽  
Gluten Free ◽  
Controlled Clinical Trials ◽  
Cutaneous Manifestations ◽  
Small Intestinal

Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every association between CD and cutaneous manifestations. An abnormal small intestinal permeability seems to be implicated in various dermatological manifestations. However, most of the associations between CD and cutaneous diseases is based on case reports and case series and a few controlled studies. To better assess the real involvement of the cutaneous district in CD patients, large multicentric controlled clinical trials are required.

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