Conformationally Locked Aryl C-Nucleosides: Synthesis of Phosphoramidite Monomers and Incorporation into Single-Stranded DNA and LNA (Locked Nucleic Acid).

ChemInform ◽  
2003 ◽  
Vol 34 (15) ◽  
Author(s):  
B. Ravindra Babu ◽  
Ashok K. Prasad ◽  
Smriti Trikha ◽  
Niels Thorup ◽  
Virinder S. Parmar ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Single Stranded Dna ◽  
Conformationally Locked

Leak-free million-fold DNA amplification with locked nucleic acid and targeted hybridization in one pot

2019 ◽  
Vol 17 (23) ◽  
pp. 5708-5713 ◽  
Author(s):  
K. Komiya ◽  
M. Komori ◽  
C. Noda ◽  
S. Kobayashi ◽  
T. Yoshimura ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Amplification ◽  
Locked Nucleic Acid ◽  
One Pot ◽  
Single Stranded Dna ◽  
Free Dna ◽  
Amplification Reaction

The leak-free DNA amplification reaction supplies a large quantity of single-stranded DNA for directing molecular nanodevices in response to nucleic acid stimuli.

Novel nucleic acid architectures involving locked nucleic acid (LNA) and pyrene residues: Results from an Indo-Danish collaboration

2005 ◽  
Vol 77 (1) ◽  
pp. 319-326 ◽  
Author(s):  
B. Ravindra Babu ◽  
Mads D. Sørensen ◽  
Patrick J. Hrdlicka ◽  
Smriti Trikha ◽  
Ashok K. Prasad ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Synthesis ◽  
Surface Area ◽  
Locked Nucleic Acid ◽  
Planar Surface ◽  
Dna Duplex ◽  
Fluorescent Tag ◽  
Conformationally Locked ◽  
Covalently Bound

We report herein our results for locked nucleic acid (LNA)-type oligonucleotides containing pyrene residues. Pyrene has a large hydrophobic and planar surface area and is therefore a potential intercalating unit; furthermore, it is interesting as a fluorescent tag when covalently bound to DNA. Synthesis and hybridization of conformationally locked universal base surrogates are described together with efficient interstrand communication as shown by the formation of pyrene excimer bands for duplexes containing 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers positioned in a zipper-like manner within a DNA duplex.

scholarly journals A mini DNA-RNA hybrid origami nanobrick

2021 ◽  
Author(s):  
Lifeng Zhou ◽  
Arun Richard Chandrasekaran ◽  
Mengwen Yan ◽  
Vibhav A. Valsangkar ◽  
Jeremy I. Feldblyum ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Dna Origami ◽  
Complex Geometries ◽  
Single Stranded Dna ◽  
Dna Scaffold

DNA origami is typically used to fold a long single-stranded DNA scaffold into nanostructures with complex geometries using many short DNA staple strands. Integration of RNA into nucleic acid nanostructures...

Trinucleotide Cap Analogue Bearing a Locked Nucleic Acid Moiety: Synthesis, mRNA Modification, and Translation for Therapeutic Applications

2021 ◽  
Author(s):  
Annamalai Senthilvelan ◽  
Tyson Vonderfecht ◽  
Muthian Shanmugasundaram ◽  
Indra Pal ◽  
Jason Potter ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Acid Moiety ◽  
Therapeutic Applications

Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology

2009 ◽  
Vol 121 (17) ◽  
pp. 3145-3149 ◽  
Author(s):  
Jakob T. Nielsen ◽  
Khalil Arar ◽  
Michael Petersen
Keyword(s):  
Nucleic Acid ◽  
Solution Structure ◽  
Locked Nucleic Acid

i-Motif Formation with Locked Nucleic Acid (LNA)

2007 ◽  
Vol 119 (48) ◽  
pp. 9380-9382 ◽  
Author(s):  
Niti Kumar ◽  
Jakob T. Nielsen ◽  
Souvik Maiti ◽  
Michael Petersen
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid

A Locked Nucleic Acid-Based Nanocrawler: Designed and Reversible Movement Detected by Multicolor Fluorescence

2013 ◽  
Vol 135 (7) ◽  
pp. 2423-2426 ◽  
Author(s):  
I. Kira Astakhova ◽  
Karol Pasternak ◽  
Meghan A. Campbell ◽  
Pankaj Gupta ◽  
Jesper Wengel
Keyword(s):  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Multicolor Fluorescence
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