ChemInform Abstract: 9-Carboxymethyl-5H,10H-imidazo[1,2-a]indeno [1,2-e]pyrazin-4-one-2-carbocylic Acid (RPR117824): Selective Anticonvulsive and Neuroprotective AMPA Antagonist.

ChemInform ◽  
2010 ◽  
Vol 33 (20) ◽  
pp. no-no
Author(s):  
Serge Mignani ◽  
et al. et al.
Keyword(s):  
Ampa Antagonist

Thin-layer chromatographic characterization of metabolites formed from an AMPA antagonist drug candidate

2001 ◽  
Vol 14 (4) ◽  
pp. 266-271 ◽  
Author(s):  
Katalin Migléczi ◽  
István Hazai ◽  
Katalin Jemnitz ◽  
Márta Pátfalusi
Keyword(s):  
Thin Layer ◽  
Drug Candidate ◽  
Ampa Antagonist ◽  
Chromatographic Characterization

The AMPA antagonist NBQX protects thalamic reticular neurons from degeneration following cardiac arrest in rats

1995 ◽  
Vol 683 (1) ◽  
pp. 117-128 ◽  
Author(s):  
Douglas T. Ross ◽  
Jane Brasko ◽  
Pete Patrikios
Keyword(s):  
Cardiac Arrest ◽  
Ampa Antagonist ◽  
Reticular Neurons

YM90K, an AMPA Antagonist, Has No Neurotoxic Effects on Cerebrocortical Neurons in Rats

1995 ◽  
Vol 134 (2) ◽  
pp. 199-204 ◽  
Author(s):  
Nobuyuki Izumisawa ◽  
Akio Kawakami ◽  
Takeji Ohata ◽  
Takanori Hanada ◽  
Riki Okeda
Keyword(s):  
Ampa Antagonist ◽  
Neurotoxic Effects

Cholinergic and electrical motoneuron-to-motoneuron synapses contribute to on-cycle excitation during swimming in Xenopus embryos

1995 ◽  
Vol 73 (3) ◽  
pp. 1005-1012 ◽  
Author(s):  
R. Perrins ◽  
A. Roberts
Keyword(s):  
Nicotinic Receptors ◽  
Local Application ◽  
Intracellular Recordings ◽  
Spinal Motoneurons ◽  
Electrical Synapses ◽  
Ampa Antagonist ◽  
Xenopus Embryos ◽  
Fast Excitation ◽  
Spiking Activity

1. We have previously shown that Xenopus spinal motoneurons make both chemical and electrical synapses with neighboring motoneurons. Because motoneurons are active during swimming, these synapses would be expected to contribute excitation to their neighbors. The significance of central motoneuron to motoneuron synapses was therefore investigated by analyzing the composition of the fast on-cycle excitation underlying spiking activity during fictive swimming in spinal motoneurons. To accomplish this we developed a method for very local application of drugs around a caudal recorded neuron while still being able to evoke and record essentially unaltered fictive swimming rostrally. 2. Intracellular recordings were made from spinal motoneurons during fictive swimming. Bicuculline (40 microM) and strychnine (2 microM) were used continuously to block inhibitory potentials locally around the motoneurons. The amplitude and duration of the fast excitation underlying spiking activity was measured before and during local applications of excitatory antagonists. 3. The nicotinic antagonists d-tubocurarine (10 microM) and dihydro-beta-erythroidine (10 microM) reduced the amplitude of this excitation by approximately 20%. Nicotinic antagonists also reduced the duration of this fast on-cycle excitation. The kainate/alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 microM) reduced the amplitude (by approximately 30%) but not the duration of the on-cycle excitation. In the presence of 100 microM Cd2+, which blocks all chemically mediated transmission, a considerable amount (50%) of on-cycle excitation remained. 4. These results suggest that 20% of the on-cycle excitation comes from activation of nicotinic receptors by naturally released acetylcholine (ACh), presumably from other motoneurons.(ABSTRACT TRUNCATED AT 250 WORDS)

The AMPA Antagonist ZK 200775 in Patients with Acute Ischaemic Stroke: A Double-Blind, Multicentre, Placebo-Controlled Safety and Tolerability Study

2005 ◽  
Vol 20 (5) ◽  
pp. 304-309 ◽  
Author(s):  
M.R. Walters ◽  
Markku Kaste ◽  
K.R. Lees ◽  
Hans C. Diener ◽  
M. Hommel ◽  
...  
Keyword(s):  
Ischaemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Double Blind ◽  
Ampa Antagonist

Talampanel, a Novel Noncompetitive AMPA Antagonist, is Neuroprotective after Traumatic Brain Injury in Rats

2001 ◽  
Vol 18 (10) ◽  
pp. 1031-1038 ◽  
Author(s):  
Ludmila Belayev ◽  
Ofelia F. Alonso ◽  
Yitao Liu ◽  
Amy S. Chappell ◽  
Weizhao Zhao ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Ampa Antagonist
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