ChemInform Abstract: The Spirotetrahydrofuran Motif: Its Role in Enhancing Ligation in Belted Ionophores, Biasing Cyclohexane Conformation, and Restricting Nucleoside/Nucleotide Conformation

ChemInform ◽  
2010 ◽  
Vol 33 (16) ◽  
pp. no-no
Author(s):  
Leo A. Paquette
Keyword(s):  
Nucleotide Conformation

Involvement of the “Occluded Nucleotide Conformation” of P-Glycoprotein in the Catalytic Pathway†

Biochemistry ◽  
2005 ◽  
Vol 44 (38) ◽  
pp. 12879-12886 ◽  
Author(s):  
Gregory Tombline ◽  
Alma Muharemagić ◽  
Lori Bartholomew White ◽  
Alan E. Senior
Keyword(s):  
P Glycoprotein ◽  
Nucleotide Conformation

scholarly journals Determination of the nucleotide conformation in the productive enzyme-substrate complexes of RNA-depolymerases

FEBS Letters ◽  
1997 ◽  
Vol 404 (2-3) ◽  
pp. 169-172 ◽  
Author(s):  
G.P Moiseyev ◽  
G.I Yakovlev ◽  
Yu.P Lysov ◽  
A.A Chernyi ◽  
K.M Polyakov ◽  
...  
Keyword(s):  
Enzyme Substrate ◽  
Nucleotide Conformation

scholarly journals A study into the effects of protein binding on nucleotide conformation

1993 ◽  
Vol 21 (6) ◽  
pp. 1369-1380 ◽  
Author(s):  
Stuart L. Moodie ◽  
Janet M. Thornton
Keyword(s):  
Protein Binding ◽  
Nucleotide Conformation

The Occluded Nucleotide Conformation of P-Glycoprotein

2005 ◽  
Vol 37 (6) ◽  
pp. 497-500 ◽  
Author(s):  
Gregory Tombline ◽  
Alan E. Senior
Keyword(s):  
P Glycoprotein ◽  
Nucleotide Conformation

scholarly journals The nature of the circular-dichoric spectra of complexes between ribonuclease A and nucleotides

1977 ◽  
Vol 167 (3) ◽  
pp. 749-757 ◽  
Author(s):  
S M Dudkin ◽  
L V Karabashyan ◽  
M Y Karpeisky ◽  
S N Mikhailov ◽  
N S Padyukova ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Ribonuclease A ◽  
Circular Dichroic Spectrum ◽  
Nucleotide Conformation ◽  
Anti Conformation ◽  
Two Factors ◽  
Wavelength Absorption ◽  
Comparison Of The Results ◽  
Circular Dichroïsm ◽  
Circular Dichroic

The circular-dichroism and proton-magnetic-resonance spectra of complexes of ribonuclease A with dihydrouridine 3′-phosphate, 2′- and 3′-CMP, arabinosyl-3′-CMP, 1-(2-hydroxyethyl)cytosine 2′-phosphate and 1-(3-hydroxypropyl)cytosine 3′-phosphate were studied. Comparison of the results shows that non-additivity of the circular-dichroic spectrum of an enzyme-nucleotide complex may be due to: (a), alteration of the circular dichroic spectrum of the nucleotide under the influence of the asymmetric protein matrix (induced dichroism), and (b) a change in the nucleotide conformation. The contribution of each of the two factors was estimated to calculate the circular-dichoroic spectra of 2′-CMP and 3′-CMP in complex with ribonuclease A. 3′-CMP in this complex was characterized by negative circular dichroism in the long-wavelength absorption band of the nucleotide, whereas 2′-CMP was characterized by positive circular dichroism. Since both nucleotides in the complex are known to be in an anti conformation, it follows that even small changes in the conformation considerably modify the circular-dichroic spectrum of the nucleotide in complex with the enzyme.

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