ChemInform Abstract: Heme Peroxidases: Structure, Function, Mechanism, and Involvement in Activation of Carcinogens

ChemInform ◽  
2010 ◽  
Vol 31 (27) ◽  
pp. no-no
Author(s):  
Marie Stiborova ◽  
Marketa Miksanova ◽  
Vaclav Martinek ◽  
Eva Frei
Keyword(s):  
Structure Function ◽  
Function Mechanism ◽  
Heme Peroxidases

scholarly journals Novel insights into structure-function mechanism and tissue-specific expression profiling of full-lengthdxrgene fromCymbopogon winterianus

FEBS Open Bio ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 325-334 ◽  
Author(s):  
Kamalakshi Devi ◽  
Budheswar Dehury ◽  
Munmi Phukon ◽  
Mahendra Kumar Modi ◽  
Priyabrata Sen
Keyword(s):  
Structure Function ◽  
Expression Profiling ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Function Mechanism

Heme Peroxidases: Structure, Function, Mechanism and Involvement in Activation of Carcinogens. A Review

2000 ◽  
Vol 65 (3) ◽  
pp. 297-325 ◽  
Author(s):  
Marie Stiborová ◽  
Markéta Mikšanová ◽  
Václav Martínek ◽  
Eva Frei
Keyword(s):  
Reaction Mechanisms ◽  
Superoxide Anion ◽  
Catalytic Properties ◽  
Review Article ◽  
Peroxy Radicals ◽  
Biological Functions ◽  
Subsequent Formation ◽  
Function Mechanism ◽  
Physiological Processes ◽  
Heme Peroxidases

Peroxidases are enzymes playing an important role in large and diverse numbers of physiological processes in organisms including human. We have attempted in this article to summarize and review the important structural and catalytic properties of principal classes of heme peroxidases as well as their biological functions. Major reactions catalyzed by these enzymes (a conventional peroxidase cycle, reactions using O2 and halogenations) and their mechanism are reviewed, too. Moreover, the reaction mechanisms by which peroxidases are implicated in bioactivation of xenobiotic chemicals are presented. Numerous chemicals including protoxicants and procarcinogens are metabolized by equally numerous chemical reactions catalyzed by peroxidases. The unifying theme is the radical nature of the oxidations. The direct conventional peroxidase reaction forming reactive species is generally responsible for the activation of procarcinogenic substrates of peroxidases. The subsequent formation of a superoxide anion radical and peroxy radicals is necessary for activation of chemicals that are poor substrates for peroxidases. The significance of studies concerning the reactions catalyzed by peroxidases is underlined in the present review article. A review with 166 references.

Histidine orientation in artificial peroxidase regioisomers as determined by paramagnetic NMR shifts

2021 ◽  
Author(s):  
Ornella Maglio ◽  
Marco Chino ◽  
Claudia Vicari ◽  
Vincenzo Pavone ◽  
Ricardo O. Louro ◽  
...  
Keyword(s):  
Structure Function ◽  
Function Analysis ◽  
Axial Ligand ◽  
Empirical Approach ◽  
Paramagnetic Nmr ◽  
Ligand Orientation ◽  
Heme Peroxidases ◽  
Semi Empirical

A semi-empirical approach allows determining the His axial-ligand orientation with respect to the porphyrin plane in synthetic heme-peroxidases, for structure/function analysis.

scholarly journals Beta-Glucan in Foods and Health Benefits

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 96
Author(s):  
Seiichiro Aoe
Keyword(s):  
Structure Function ◽  
Mechanism Of Action ◽  
Health Benefits ◽  
Beta Glucan ◽  
Function Mechanism

Many articles and manuscripts focusing on the structure, function, mechanism of action, and effects of β-glucan have been published recently [...]

scholarly journals The role of CYP17A1 in prostate cancer development: structure, function, mechanism of action, genetic variations and its inhibition

2017 ◽  
Vol 36 (05) ◽  
pp. 487-499 ◽  
Author(s):  
Monika Kmeťová Sivoňová ◽  
Jana Jurečeková ◽  
Zuzana Tatarková ◽  
Peter Kaplán ◽  
Lucia Lichardusová ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Structure Function ◽  
Mechanism Of Action ◽  
Genetic Variations ◽  
Cancer Development ◽  
Function Mechanism ◽  
Prostate Cancer Development ◽  
Development Structure
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