Human mitochondrial RNA polymerase: Structure–function, mechanism and inhibition

2012 ◽  
Vol 1819 (9-10) ◽  
pp. 948-960 ◽  
Author(s):  
Jamie J. Arnold ◽  
Eric D. Smidansky ◽  
Ibrahim M. Moustafa ◽  
Craig E. Cameron
Keyword(s):  
Rna Polymerase ◽  
Structure Function ◽  
Mitochondrial Rna ◽  
Function Mechanism ◽  
Mitochondrial Rna Polymerase ◽  
Polymerase Structure

scholarly journals Assembly and Cryo-EM structure determination of yeast mitochondrial RNA polymerase initiation complex intermediates

2021 ◽  
Vol 2 (2) ◽  
pp. 100431
Author(s):  
Sergio E. Martinez ◽  
Anupam Singh ◽  
Brent De Wijngaert ◽  
Shemaila Sultana ◽  
Chhaya Dharia ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Structure Determination ◽  
Mitochondrial Rna ◽  
Initiation Complex ◽  
Mitochondrial Rna Polymerase

Direct in vitro action of thyroid hormones on mitochondrial RNA-polymerase

1986 ◽  
Vol 11 (4) ◽  
pp. 205-211 ◽  
Author(s):  
G. Martino ◽  
C. Covello ◽  
R. De Giovanni ◽  
R. Filippelli ◽  
G. Pitrelli
Keyword(s):  
Thyroid Hormones ◽  
Rna Polymerase ◽  
Mitochondrial Rna ◽  
Mitochondrial Rna Polymerase

scholarly journals Cryo-EM structures reveal transcription initiation steps by yeast mitochondrial RNA polymerase

2020 ◽  
Author(s):  
Brent De Wijngaert ◽  
Shemaila Sultana ◽  
Chhaya Dharia ◽  
Hans Vanbuel ◽  
Jiayu Shen ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Transcription Initiation ◽  
Large Scale ◽  
Rna Synthesis ◽  
Mitochondrial Rna ◽  
Initiation Complex ◽  
Mitochondrial Rna Polymerase ◽  
Catalytically Active ◽  
Promoter Melting ◽  
Antiviral Nucleosides

Cryo-EM structures of transcription pre-initiation complex (PIC) and initiation complex (IC) of yeast mitochondrial RNA polymerase show fully resolved transcription bubbles and explain promoter melting, template alignment, DNA scrunching, transition into elongation, and abortive synthesis. Promoter melting initiates in PIC with MTF1 trapping the −4 to −2 non-template (NT) bases in its NT-groove. Transition to IC is marked by a large-scale movement that aligns the template with RNA at the active site. RNA synthesis scrunches the NT strand into an NT-loop, which interacts with centrally positioned MTF1 C-tail. Steric clashes of the C-tail with RNA:DNA and NT-loop, and dynamic scrunching-unscrunching of DNA explain abortive synthesis and transition into elongation. Capturing the catalytically active IC-state with UTPαS poised for incorporation enables modeling toxicity of antiviral nucleosides/nucleotides.

scholarly journals TFB2 Is a Transient Component of the Catalytic Site of the Human Mitochondrial RNA Polymerase

Cell ◽  
2009 ◽  
Vol 139 (5) ◽  
pp. 934-944 ◽  
Author(s):  
Marina Sologub ◽  
Dmitry Litonin ◽  
Michael Anikin ◽  
Arkady Mustaev ◽  
Dmitry Temiakov
Keyword(s):  
Rna Polymerase ◽  
Catalytic Site ◽  
Mitochondrial Rna ◽  
Transient Component ◽  
Mitochondrial Rna Polymerase

scholarly journals The effect of rifampicin on mitochondrial RNA polymerase from rat liver

FEBS Letters ◽  
1970 ◽  
Vol 10 (1) ◽  
pp. 54-56 ◽  
Author(s):  
M.N. Gadaleta ◽  
M. Greco ◽  
C. Saccone
Keyword(s):  
Rna Polymerase ◽  
Rat Liver ◽  
Mitochondrial Rna ◽  
Mitochondrial Rna Polymerase
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