ChemInform Abstract: Solvent-Free Organic Reactions Using Microwaves: Applications in the Synthesis of Heterocyclic Compounds

ChemInform ◽  
2010 ◽  
Vol 30 (13) ◽  
pp. no-no
Author(s):  
Rajender S. Varma ◽  
Dalip Kumar ◽  
Rajender Dahiya ◽  
Per J. Liesen
Keyword(s):  
Heterocyclic Compounds ◽  
Solvent Free ◽  
Organic Reactions

The Synthesis of Heterocyclic Compounds Based on 3-Formylchromone via Organic Reactions

Heterocycles ◽  
2020 ◽  
Vol 100 (7) ◽  
pp. 993 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Parisa Mofatehnia ◽  
Fatemeh Mohajer ◽  
Razieh Moradi
Keyword(s):  
Heterocyclic Compounds ◽  
Organic Reactions

Studies on the thermal coking of bitumen. I. The use of pyrene-d10 as a probe for evaluating the extent of hydrogen shuttling reaction

1991 ◽  
Vol 69 (1) ◽  
pp. 116-120 ◽  
Author(s):  
M. J. Kirk ◽  
T. S. Sorensen
Keyword(s):  
Free Radicals ◽  
Key Words ◽  
Hydrogen Exchange ◽  
Solvent Free ◽  
Hydrogen Donor ◽  
Organic Reactions ◽  
Hydrogen Atoms ◽  
Donor Solvent ◽  
Key Words Bitumen

The organic reactions that take place during the thermal coking of bitumen are extremely complex and deep-seated, but obviously hydrogen atoms originally attached to carbons that form coke will have moved to a new carbon site (net addition of hydrogen, resulting in upgraded bitumen). Accompanying this process, one expects some general hydrogen shuttling between non-coking molecules. This paper describes an approach to determing the extent of this latter process by the addition of a small amount of perdeuterated pyrene to the bitumen prior to the coking operation. The in situ pyrene functions as in indicator, allowing one to establish the extent and other mechanistic details of the "hydrogen donor" reactions that take place during coking. There is no indication that the pyrene substantially modifies the normal course of the reaction, hence the analogy to an indicator. Key words: bitumen coking, pyrene, hydrogen exchange, donor solvent, free radicals.

ChemInform Abstract: Solvent-Free Microwave-Assisted Organic Reactions. Preparation of β-Keto Esters.

ChemInform ◽  
2010 ◽  
Vol 31 (34) ◽  
pp. no-no
Author(s):  
Massimo Gianotti ◽  
Giorgio Martelli ◽  
Giuseppe Spunta ◽  
Eileen Campana ◽  
Mauro Panunzio ◽  
...  
Keyword(s):  
Solvent Free ◽  
Organic Reactions ◽  
Keto Esters ◽  
Microwave Assisted

scholarly journals Organic synthesis by Twin Screw Extrusion (TSE): continuous, scalable and solvent-free

2017 ◽  
Vol 19 (6) ◽  
pp. 1507-1518 ◽  
Author(s):  
Deborah E. Crawford ◽  
Clodagh K. G. Miskimmin ◽  
Ahmad B. Albadarin ◽  
Gavin Walker ◽  
Stuart L. James
Keyword(s):  
Organic Synthesis ◽  
Solvent Free ◽  
Pure Form ◽  
Organic Reactions ◽  
Twin Screw Extrusion ◽  
Continuous Basis ◽  
Screw Extrusion ◽  
Twin Screw ◽  
Work Up

Several organic reactions have been achieved quantitatively without any added solvent, using solid or liquid reagents, on a continuous basis; products are typically obtained directly in analytically pure form, requiring no work-up.

Green Synthesis, Biological Activity Evaluation, and Molecular Docking Studies of Aryl Alkylidene 2, 4-thiazolidinedione and Rhodanine Derivatives as Antimicrobial Agents

2020 ◽  
Vol 22 (10) ◽  
pp. 716-727
Author(s):  
Malihe Akhavan ◽  
Naser Foroughifar ◽  
Hoda Pasdar ◽  
Ahmadreza Bekhradnia
Keyword(s):  
Antimicrobial Activity ◽  
Free Energy ◽  
Molecular Docking ◽  
Heterocyclic Compounds ◽  
Antimicrobial Agents ◽  
Binding Free Energy ◽  
Docking Studies ◽  
Solvent Free ◽  
Gram Negative ◽  
Molecular Docking Studies

Aim and Objective: The magic scaffolds rhodanine and thiazolidine are very important heterocyclic compounds in drug design and discovery. Those are important heterocyclic compounds that have attracted a great deal of attention due to the fact that they exhibit a variety of bioactivities including antibacterial, antifungal, antiviral, antimalarial, and anti-inflammatory activities. These agents often exhibit selective toxicity. The goal of this study was molecular docking, green and solvent-free efficient synthesis of a new series of hetero/aromatic substituted rhodanine and thiazolidine analogues and then investigation of their antimicrobial activity. Materials and Methods: To a mixture of TZD or rhodanine (1 mmol) in the presence of ionic liquid ChCl/urea, various aldehyde (1 mmol) was added. After completion of the reaction, obtained crude compound was collected by filtration and products were recrystallized from ethanol. The binding-free energy between all synthesized compounds with 3EEJ protein (C. glabrata enzyme) were obtained by molecular docking studies. These compounds were evaluated using microdilution method against (ATCC 6538) and (ATCC 12228) Gram-negative, (ATCC 8739) and (ATCC 9027) as Gram-positive and (ATCC 1012), (ATCC 339), C. (ATCC 1057), (ATCC 503), (ATCC 340) and (ATCC 194) as fungi. Results: All of the acceptable products were determined by 1H NMR, 13C NMR, Mas and FT-IR spectroscopy. The binding-free energy between compounds 10a and 10b with 3EEJ protein were found to be -8.08 kcal/mol and -8.15 kcal/mol, respectively. These compounds having a heteroaromatic ring attached to the TZD or rhodanine core showed excellent antimicrobial activity with MIC values of 0.25-8 μg/mL (compound 10a) and 0.5-16 μg/mL (compound 10b) against the most tested fungi strains, Gram-positive and Gram-negative bacteria. Conclusion: A convenient and rapid method has been developed for the synthesis of rhodanine and thiazolidine-2,4-dione (TZD) derivatives as efficient antimicrobial agents using a Deep Eutectic Ionic Liquids (DEILs) choline chloride urea under solvent-free condition. Among the newly synthesized compounds, (Z)-5-((quinoxalin-3-yl) methylene) thiazolidine-2, 4-dione (10a) and (Z)- 5- ((quinoxalin-3-yl) methylene)-2-thioxothiazolidin-one (10b) exerted the promising effect and these compounds can be considered to be further probed as inhibitors of cgDHFR enzyme.

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