ChemInform Abstract: Model Studies for the Synthesis of the Marine Hepatotoxin Cylindrospermopsin. Preparation of a Bicyclic Guanidine with the Hydroxymethyluracil Side Chain.

ChemInform ◽  
2010 ◽  
Vol 29 (50) ◽  
pp. no-no
Author(s):  
B. B. SNIDER ◽  
C. XIE
1983 ◽  
Vol 36 (4) ◽  
pp. 803 ◽  
Author(s):  
IK Boddy ◽  
RC Cambie ◽  
G Dixon ◽  
PS Rutledge ◽  
PD Woodgate

The Claisen rearrangement of some allyl naphthalen-1-yl ethers has been examined, together with methods for modification of the resulting 2-ally1 side chain. Isomerization of the C-allyl substituent to a prop-1-enyl group followed by ozonolysis gives a formyl derivative, while ozonolysis of a 2-(2-methylprop-2-enyl) moiety or mercuriation of a 2-(2-chloroprop-2-enyl) substituent leads to an acetonyl derivative. Treatment of phenols with iodine(I) acetate and an excess of silver(I) acetate gives 4-hydroxyaryl acetates, probably via dienone intermediates.


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