ChemInform Abstract: Synthesis and Biological Activities of Aldose Reductase Inhibitors Bearing Acyl Benzenesulfonamides as Carboxylic Acid Surrogates.

ChemInform ◽  
2010 ◽  
Vol 29 (28) ◽  
pp. no-no
Author(s):  
I. O. DONKOR ◽  
Y. S. ABDEL-GHANY ◽  
P. F. KADOR ◽  
T. MIZOGUCHI ◽  
A. BARTOSZKO-MALIK ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Aldose Reductase ◽  
Biological Activities ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors

Synthesis and biological activities of aldose reductase inhibitors bearing acyl benzenesulfonamides as carboxylic acid surrogates

1998 ◽  
Vol 33 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Isaac O. Donkor ◽  
Yasser S. Abdel-Ghany ◽  
Peter F. Kador ◽  
Tadashi Mizoguchi ◽  
Anita Bartoszko-Malik ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Aldose Reductase ◽  
Biological Activities ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors

scholarly journals Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2867
Author(s):  
Lucia Kovacikova ◽  
Marta Soltesova Prnova ◽  
Magdalena Majekova ◽  
Andrej Bohac ◽  
Cimen Karasu ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Complications ◽  
Therapeutic Potential ◽  
Ex Vivo ◽  
Biological Activities ◽  
In Vivo Models ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors ◽  
Promising Therapeutic Approach

Aldose reductase (AR, ALR2), the first enzyme of the polyol pathway, is implicated in the pathophysiology of diabetic complications. Aldose reductase inhibitors (ARIs) thus present a promising therapeutic approach to treat a wide array of diabetic complications. Moreover, a therapeutic potential of ARIs in the treatment of chronic inflammation-related pathologies and several genetic metabolic disorders has been recently indicated. Substituted indoles are an interesting group of compounds with a plethora of biological activities. This article reviews a series of indole-based bifunctional aldose reductase inhibitors/antioxidants (ARIs/AOs) developed during recent years. Experimental results obtained in in vitro, ex vivo, and in vivo models of diabetic complications are presented. Structure–activity relationships with respect to carboxymethyl pharmacophore regioisomerization and core scaffold modification are discussed along with the criteria of ‘drug-likeness”. Novel promising structures of putative multifunctional ARIs/AOs are designed.

Design of Benzothiazolone‐Based Carboxylic Acid Aldose Reductase Inhibitors

2021 ◽  
Vol 6 (20) ◽  
pp. 4874-4880
Author(s):  
Yanqi Lei ◽  
Xin Zhang ◽  
Xiaonan Zhang ◽  
Long Xu ◽  
Wenchao Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Aldose Reductase ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors

Discovery of potential aldose reductase inhibitors using in silico docking studies

2012 ◽  
Vol 12 (2) ◽  
pp. 157-161 ◽  
Author(s):  
Arumugam Madeswaran ◽  
Muthuswamy Umamaheswari ◽  
Kuppusamy Asokkumar ◽  
Thirumalaisamy Sivashanmugam ◽  
Varadharajan Subhadradevi ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
In Silico ◽  
Docking Studies ◽  
In Silico Docking ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors

Isolation of aldose reductase inhibitors from the flowers ofChrysanthemum boreale

1995 ◽  
Vol 18 (2) ◽  
pp. 65-68 ◽  
Author(s):  
Kuk Hyun Shin ◽  
Sam Sik Kang ◽  
Eun Ah Seo ◽  
Seung Won Shin
Keyword(s):  
Aldose Reductase ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors

ChemInform Abstract: Thermorubin and 2-Hydroxyphenyl Acetic Acid, Aldose Reductase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 27 (17) ◽  
pp. no-no
Author(s):  
K. HAYASHI ◽  
M. DOMBOU ◽  
M. SEKIYA ◽  
H. NAKAJIMA ◽  
T. FUJITA ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Aldose Reductase ◽  
Aldose Reductase Inhibitors ◽  
Reductase Inhibitors
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