ChemInform Abstract: A Novel Approach Towards 2,3,5-Trisubstituted Thiophenes via Tandem Michael Addition/Intramolecular Knoevenagel Condensation.

ChemInform ◽  
2010 ◽  
Vol 28 (23) ◽  
pp. no-no
Author(s):  
D. OBRECHT ◽  
F. GERBER ◽  
D. SPRENGER ◽  
T. MASQUELIN
Keyword(s):  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Novel Approach

Nmp-based ionic liquids: Recyclable catalysts for both hetero-Michael addition and Knoevenagel condensation in water

2018 ◽  
Vol 48 (9) ◽  
pp. 1060-1067 ◽  
Author(s):  
Pengkun Yang ◽  
Yawei Liu ◽  
Ling Chai ◽  
Zhenzhen Lai ◽  
Xiaomin Fang ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Recyclable Catalysts

Water-prompted synthesis of alkyl nitrile derivatives via Knoevenagel condensation and Michael addition reaction

2011 ◽  
Vol 13 (3) ◽  
pp. 566 ◽  
Author(s):  
Ebrahim Soleimani ◽  
Mohammad Mehdi Khodaei ◽  
Nasim Batooie ◽  
Mostafa Baghbanzadeh
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Knoevenagel Condensation ◽  
Michael Addition Reaction

scholarly journals Ball milling for the quantitative and specific solvent-free Knoevenagel condensation + Michael addition cascade in the synthesis of various 2-amino-4-aryl-3-cyano-4H-chromenes without heating

RSC Advances ◽  
2014 ◽  
Vol 4 (89) ◽  
pp. 48191-48201 ◽  
Author(s):  
Omid Hosseinchi Qareaghaj ◽  
Sara Mashkouri ◽  
M. Reza Naimi-Jamal ◽  
Gerd Kaupp
Keyword(s):  
Ball Milling ◽  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Solvent Free

Various 2-amino-4-aryl-3-cyano-4H-chromenes have been quantitatively prepared by dry ball milling in the presence of catalytic Na2CO3. The orientation specificities are discussed; existing misattributions are pointed out and clarified by NMR.

Enantioselective total synthesis of (S)-nakinadine B

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25913-25917 ◽  
Author(s):  
Yuvraj Garg ◽  
Satyendra Kumar Pandey
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Michael Addition ◽  
Marine Natural Product ◽  
Enantioselective Total Synthesis ◽  
Novel Approach ◽  
Key Steps

A novel approach for the synthesis of (S)-nakinadine B, a marine natural product is described. The synthesis utilizes the optimized combination of organocatalyzed Michael addition and aminoxylation reactions as key steps.

scholarly journals Synthesis and Molecular Docking Studies of N,N-Dimethyl Arylpyranopyrimidinedione Derivatives

SynOpen ◽  
2022 ◽  
Vol 06 (01) ◽  
pp. 1-6
Author(s):  
Sivan Velmathi ◽  
Srinivasan Prabhakaran
Keyword(s):  
Molecular Docking ◽  
Reaction Mechanism ◽  
Binding Energy ◽  
Michael Addition ◽  
Barbituric Acid ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Docking Studies ◽  
Reaction Sequence ◽  
Kinesin Eg5

AbstractThe synthesis of N,N-dimethyl arylpyranopyrimidinedione derivatives from aromatic aldehydes, N-methyl-1-(methylthio)-2-nitroethamine (NMSM) and 1,3-dimethyl barbituric acid, in the presence of piperidine as a catalyst, is reported. The reaction mechanism involves a Knoevenagel condensation, followed by Michael addition and intramolecular O-cyclization reaction sequence. The synthesized compounds were docked with human kinesin Eg5 protein to calculate binding energy, inhibition constant and H-bond interaction. All the compounds show good binding affinity towards the protein, with significant docking score.

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