ChemInform Abstract: One-Pot Efficient Green Synthesis of Spirooxindole-Annulated Thiopyran Derivatives via Knoevenagel Condensation Followed by Michael Addition.

ChemInform ◽  
2012 ◽  
Vol 43 (29) ◽  
pp. no-no
Author(s):  
K. C. Majumdar ◽  
Sudipta Ponra ◽  
Raj Kumar Nandi
Keyword(s):  
Green Synthesis ◽  
Michael Addition ◽  
Knoevenagel Condensation ◽  
One Pot

Base-Promoted Tandem Cyclization for the Synthesis of Polyfunctional 2-Hydroxy-2,3-dihydrofurans from Arylglyoxal Monohydrates and 3-(1H-Indol-3-yl)-3-oxopropanenitrile

Synlett ◽  
2018 ◽  
Vol 29 (14) ◽  
pp. 1926-1932
Author(s):  
Yi Liu ◽  
An-Xin Wu ◽  
Qun Cai ◽  
Hui-Yang Sheng ◽  
Deng-Kui Li
Keyword(s):  
Functional Groups ◽  
Michael Addition ◽  
Knoevenagel Condensation ◽  
One Pot ◽  
Wide Range ◽  
Reaction Proceeds ◽  
Tandem Cyclization ◽  
Arylglyoxal Monohydrates

An efficient base-promoted tandem cyclization for the synthesis of polyfunctional 2-hydroxy-2,3-dihydrofurans from arylglyoxal monohydrates and 3-(1H-indol-3-yl)-3-oxopropanenitrile has been established. The investigation of the mechanism suggested that this reaction proceeds through a Knoevenagel condensation–Michael addition–oxidation–cyclization sequence. This method demonstrates the compatibility with a wide range of functional groups to produce the 2-hydroxy-2,3-dihydrofuran scaffolds in good to excellent yields in one pot.

Synthesis of Dihydrospiro Furo[2,3-c]pyrazoles Promoted by Hypervalent Iodine in Water

Synlett ◽  
2018 ◽  
Vol 29 (08) ◽  
pp. 1037-1042 ◽  
Author(s):  
Krishnaiah Atmakur ◽  
Ashok Kale ◽  
Nagaraju Medishetti ◽  
Chiranjeevi Bingi
Keyword(s):  
Ambient Temperature ◽  
Aqueous Medium ◽  
Michael Addition ◽  
Title Compound ◽  
Knoevenagel Condensation ◽  
Hypervalent Iodine ◽  
One Pot ◽  
Green Protocol ◽  
Work Up

A simple, green protocol has been accomplished for the synthesis of dihydrospirofuro[2,3-c]pyrazoles in aqueous medium involving pyrazolone and aldehydes in a one-pot reaction promoted by bis(acetoxy)iodobenzene (BAIB) at ambient temperature. The protocol presented herein describes a new transformation where two molecules of pyrazolone react with an aldehyde in a Knoevenagel condensation followed by a Michael addition, and the resulting dienol was rearranged to the title compound. High compatibility, easy work-up, and excellent yields are the advantages of this protocol.

scholarly journals Synthesis, Characterization of Novel Benzothiophene

2021 ◽  
pp. 38-41
Author(s):  
Veerappan Jeyachandranan
Keyword(s):  
Michael Addition ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Domino Reactions ◽  
One Pot ◽  
The One

A library of novel benzo[b] thiophenehave been synthesized regioselectively in good yields through the one-pot domino reactions of thiophenone, malononitrile and aromatic aldehydes in the presence of NaOEt. This transformation presumably involves Knoevenagel condensation–Michael addition–intramolecular Thorpe-Ziegler cyclization-Tautomerization-Elimination sequence of reactions.

scholarly journals Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process

2018 ◽  
Vol 14 ◽  
pp. 2907-2915 ◽  
Author(s):  
Muthumani Muthu ◽  
Rakkappan Vishnu Priya ◽  
Abdulrahman I Almansour ◽  
Raju Suresh Kumar ◽  
Raju Ranjith Kumar
Keyword(s):  
Michael Addition ◽  
Nucleophilic Addition ◽  
Ammonium Acetate ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Air Oxidation ◽  
One Pot ◽  
Tandem Process ◽  
The One

The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation–nucleophilic addition to carbonyl–Michael addition–N-cyclization–elimination–air oxidation sequence to afford structurally intriguing indole–cycloalkyl[b]pyridine-3-carbonitrile hybrid heterocycles in excellent yields.

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