ChemInform Abstract: Synthesis of Sulfated Polysaccharides and Oligosaccharide Derivatives with Potent anti-AIDS Virus Activity

ChemInform ◽  
2010 ◽  
Vol 28 (22) ◽  
pp. no-no
Author(s):  
T. URYU ◽  
K. KATSURAYA ◽  
T. YOSHIDA
Keyword(s):  
Sulfated Polysaccharides ◽  
Virus Activity ◽  
Aids Virus

Synthesis of sulfated octadecyl ribo-oligosaccharides with potent anti-AIDS virus activity by ring-opening polymerization of a 1,4-anhydroribose derivative

1996 ◽  
Vol 282 (1) ◽  
pp. 113-123 ◽  
Author(s):  
YoonSoung Choi ◽  
Takashi Yoshida ◽  
Toru Mimura ◽  
Yutaro Kaneko ◽  
Hideki Nakashima ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Virus Activity ◽  
Aids Virus

Synthesis of Cellulose-Type Polyriboses and Their Branched Sulfates with Anti-AIDS Virus Activity by Selective Ring-Opening Copolymerization of 1,4-Anhydro-.alpha.-D-ribopyranose Derivatives

1994 ◽  
Vol 27 (16) ◽  
pp. 4422-4428 ◽  
Author(s):  
Takashi Yoshida ◽  
Chengpei Wu ◽  
Lixin Song ◽  
Toshiyuki Uryu ◽  
Yutaro Kaneko ◽  
...  
Keyword(s):  
Ring Opening ◽  
Virus Activity ◽  
Aids Virus ◽  
Selective Ring Opening

scholarly journals Synthesis of Sulfated Deoxy-Ribofuranans Having Selective Anti-AIDS Virus Activity by Ring-Opening Copolymerization of 1,4-Anhydro Ribose Derivatives

1997 ◽  
Vol 29 (4) ◽  
pp. 374-379 ◽  
Author(s):  
Yoon Soung Choi ◽  
Byoung Won Kang ◽  
Rong Lu ◽  
Mitsuru Osawa ◽  
Kazuyuki Hattori ◽  
...  
Keyword(s):  
Ring Opening ◽  
Virus Activity ◽  
Aids Virus

scholarly journals Anti-AIDS Virus Activity in vitro of Dextran Sulfates Obtained by Sulfation of Synthetic and Natural Dextrans

1993 ◽  
Vol 25 (10) ◽  
pp. 1069-1077 ◽  
Author(s):  
Takashi Yoshida ◽  
Hideki Nakashima ◽  
Naoki Yamamoto ◽  
Toshiyuki Uryu
Keyword(s):  
Virus Activity ◽  
Aids Virus

The Fine Structure of the Sheath of Volvox Carteri f. Weismannia

1977 ◽  
Vol 35 ◽  
pp. 346-347
Author(s):  
Regina Birchem
Keyword(s):  
Developmental Stages ◽  
Ruthenium Red ◽  
Sulfated Polysaccharides ◽  
Volvox Carteri ◽  
High Voltage Electron Microscopy ◽  
Ultrastructural Studies ◽  
Voltage Electron ◽  
Sheath Formation ◽  
And Inversion ◽  
Sheath Material

Spheroids of the green colonial alga Volvox consist of biflagellate Chlamydomonad-like cells embedded in a transparent sheath. The sheath, important as a substance through which metabolic materials, light, and the sexual inducer must pass to and from the cells, has been shown to have an ordered structure (1,2). It is composed of both protein and carbohydrate (3); studies of V. rousseletii indicate an outside layer of sulfated polysaccharides (4).Ultrastructural studies of the sheath material in developmental stages of V. carteri f. weismannia were undertaken employing variations in the standard fixation procedure, ruthenium red, diaminobenzidine, and high voltage electron microscopy. Sheath formation begins after the completion of cell division and inversion of the daughter spheroids. Golgi, rough ER, and plasma membrane are actively involved in phases of sheath synthesis (Fig. 1). Six layers of ultrastructurally differentiated sheath material have been identified.

Compounds with anti-respiratory syncytial virus activity from endophytic fungus Pestalotiopsis thea

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
PF Uzor ◽  
DC Odimegwu ◽  
W Ebrahim ◽  
PO Osadebe ◽  
NJ Nwodo ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Endophytic Fungus ◽  
Virus Activity ◽  
Syncytial Virus

Further Studies on the Mechanisms for the Antithrombotic Effects of Sulfated Polysaccharides in Rabbits

1988 ◽  
Vol 60 (02) ◽  
pp. 188-192 ◽  
Author(s):  
F A Ofosu ◽  
F Fernandez ◽  
N Anvari ◽  
C Caranobe ◽  
F Dol ◽  
...  
Keyword(s):  
Antithrombin Iii ◽  
Ex Vivo ◽  
Thrombus Formation ◽  
Minimum Weight ◽  
Sulfated Polysaccharides ◽  
Pentosan Polysulfate ◽  
Heparin Cofactor Ii ◽  
Thrombin Inhibition ◽  
The Relationship ◽  
Prothrombin Activation

SummaryA recent study (Fernandez et al., Thromb. Haemostas. 1987; 57: 286-93) demonstrated that when rabbits were injected with the minimum weight of a variety of glycosaminoglycans required to inhibit tissue factor-induced thrombus formation by —80%, exogenous thrombin was inactivated —twice as fast in the post-treatment plasmas as the pre-treatment plasmas. In this study, we investigated the relationship between inhibition of thrombus formation and the extent of thrombin inhibition ex vivo. We also investigated the relationship between inhibition of thrombus formation and inhibition of prothrombin activation ex vivo. Four sulfated polysaccharides (SPS) which influence coagulation in a variety of ways were used in this study. Unfractionated heparin and the fraction of heparin with high affinity to antithrombin III potentiate the antiproteinase activity of antithrombin III. Pentosan polysulfate potentiates the activity of heparin cofactor II. At less than 10 pg/ml of plasma, all three SPS also inhibit intrinsic prothrombin activation. The fourth agent, dermatan sulfate, potentiates the activity of heparin cofactor II but fails to inhibit intrinsic prothrombin activation even at concentrations which exceed 60 pg/ml of plasma. Inhibition of thrombus formation by each sulfated polysaccharides was linearly related to the extent of thrombin inhibition achieved ex vivo. These observations confirm the utility of catalysis of thrombin inhibition as an index for assessing antithrombotic potential of glycosaminoglycans and other sulfated polysaccharides in rabbits. With the exception of pentosan polysulfate, there was no clear relationship between inhibition of thrombus formation and inhibition of prothrombin activation ex vivo.

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