Synthesis of branched ribofuranans and their sulfates with strong anti-AIDS virus activity by selective ring-opening copolymerization of 1,4-anhydro-α-D-ribopyranose derivatives.

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pp. 4051-4057 ◽  
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Yoshiaki Katayama ◽  
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Synthesis ◽  
2018 ◽  
Vol 51 (07) ◽  
pp. 1655-1661 ◽  
Author(s):  
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An iridium-catalyzed branch-selective ring-opening reaction of vinylcyclopropanes with indoles has been established, which afforded C3-allylindoles in generally good to excellent yields (up to 95%). Considering that no wastes were generated in the whole process and branch-selective ring-opening reaction of vinylcyclopropanes was rarely reported, this strategy not only can be regarded as a highly atom-economic approach for C3-allylindoles, but also will greatly enrich the chemistry of vinylcyclopropanes.


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