ChemInform Abstract: An Iterative Approach to Biologically Important Fused Polycyclic Ethers via Acyl Radical Cyclizations.

ChemInform ◽  
2010 ◽  
Vol 27 (49) ◽  
pp. no-no
Author(s):  
P. A. EVANS ◽  
J. D. ROSEMAN ◽  
L. T. GARBER
Keyword(s):  
Radical Cyclizations ◽  
Iterative Approach ◽  
Acyl Radical ◽  
Polycyclic Ethers

Acyl radical cyclizations in synthesis. part 2 further substituent effects on the mode and efficiency of cyclizaion of 6-heptenoyl radicals.

Tetrahedron ◽  
1990 ◽  
Vol 46 (6) ◽  
pp. 2135-2148 ◽  
Author(s):  
David Crich ◽  
K. Angeline Eustace ◽  
Simon M. Fortt ◽  
Timodthy J. Ritchie
Keyword(s):  
Substituent Effects ◽  
Radical Cyclizations ◽  
Acyl Radical

Convergent Assembly of Polycyclic Ethers via Acyl Radical Addition to Unactivated Enol Ether

2006 ◽  
Vol 8 (25) ◽  
pp. 5801-5804 ◽  
Author(s):  
Masayuki Inoue ◽  
Yuuki Ishihara ◽  
Shuji Yamashita ◽  
Masahiro Hirama
Keyword(s):  
Radical Addition ◽  
Enol Ether ◽  
Acyl Radical ◽  
Convergent Assembly ◽  
Polycyclic Ethers

Synthesis of polyhydroxylated xanthones via acyl radical cyclizations

2012 ◽  
Vol 53 (2) ◽  
pp. 111-114 ◽  
Author(s):  
George A. Kraus ◽  
Feng Liu
Keyword(s):  
Radical Cyclizations ◽  
Acyl Radical

Synthetic and Computational Studies of Acyl Radical Cyclizations with β-Alkoxyacrylates: Formal Synthesis of (±)-Longianone

2011 ◽  
Vol 64 (4) ◽  
pp. 409 ◽  
Author(s):  
Heather M. Aitken ◽  
Carl H. Schiesser ◽  
Christopher D. Donner
Keyword(s):  
Density Functional ◽  
Density Functional Theory Calculations ◽  
Radical Cyclizations ◽  
Computational Studies ◽  
Fungal Metabolite ◽  
Acyl Radical ◽  
Functional Theory ◽  
Formal Synthesis ◽  
Acyl Radicals ◽  
Insight Into

An investigation into the cyclization of acyl radicals with mono- and disubstituted β-alkoxyacrylates is described. Ether-tethered acyl radicals, generated directly from the corresponding aldehyde, undergo cyclization to form dioxaspiro heterocyclic systems including 1,7-dioxaspiro[4,4]nonane-4,8-dione and 1,8-dioxaspiro[5,4]decane-5,9-dione. This strategy is applied to a concise formal synthesis of the fungal metabolite longianone. Density functional theory calculations provide insight into the chemistry of the acyl radicals in this study.

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