ChemInform Abstract: Model Insect Antifeedants. Synthesis of Azadiradione Fragments Through Acyl Radical Cyclizations and Stannane Coupling Reactions.

ChemInform ◽  
2010 ◽  
Vol 27 (29) ◽  
pp. no-no
Author(s):  
A. FERNANDEZ-MATEOS ◽  
G. P. COCA ◽  
R. RUBIO GONZALES ◽  
C. TAPIA HERNANDEZ
Keyword(s):  
Radical Cyclizations ◽  
Coupling Reactions ◽  
Abstract Model ◽  
Acyl Radical ◽  
Insect Antifeedants

Acyl radical cyclizations in synthesis. part 2 further substituent effects on the mode and efficiency of cyclizaion of 6-heptenoyl radicals.

Tetrahedron ◽  
1990 ◽  
Vol 46 (6) ◽  
pp. 2135-2148 ◽  
Author(s):  
David Crich ◽  
K. Angeline Eustace ◽  
Simon M. Fortt ◽  
Timodthy J. Ritchie
Keyword(s):  
Substituent Effects ◽  
Radical Cyclizations ◽  
Acyl Radical

Synthesis of polyhydroxylated xanthones via acyl radical cyclizations

2012 ◽  
Vol 53 (2) ◽  
pp. 111-114 ◽  
Author(s):  
George A. Kraus ◽  
Feng Liu
Keyword(s):  
Radical Cyclizations ◽  
Acyl Radical

Bromine-Radical-Mediated Synthesis of β-Functionalized β,γ- and δ,ε-Unsaturated Ketones via C–H Functionalization of Aldehydes

Synlett ◽  
2017 ◽  
Vol 28 (14) ◽  
pp. 1733-1737 ◽  
Author(s):  
Takashi Kippo ◽  
Yuki Kimura ◽  
Mitsuhiro Ueda ◽  
Takahide Fukuyama ◽  
Ilhyong Ryu
Keyword(s):  
Hydrogen Abstraction ◽  
Coupling Reactions ◽  
Elimination Reaction ◽  
Acyl Radical ◽  
Unsaturated Ketones ◽  
Radical Initiator ◽  
Three Component Coupling

The bromine-radical-mediated allylation reaction of aldehydes was studied. In the presence of V-65 as radical initiator, the reaction of aldehydes with allyl bromides gave β,γ-unsaturated ketones in good yields (13 examples, 45–84%). The reaction is triggered by hydrogen abstraction from the aldehyde by bromine radical to form an acyl radical, which undergoes an SH2′-type addition–elimination reaction with allyl bromides to give coupling products with liberation of bromine radical. Three-component coupling reactions comprising aldehydes, electron-deficient alkenes, and methallyl bromide also proceeded to give δ,ε-unsaturated ketones.

Synthetic and Computational Studies of Acyl Radical Cyclizations with β-Alkoxyacrylates: Formal Synthesis of (±)-Longianone

2011 ◽  
Vol 64 (4) ◽  
pp. 409 ◽  
Author(s):  
Heather M. Aitken ◽  
Carl H. Schiesser ◽  
Christopher D. Donner
Keyword(s):  
Density Functional ◽  
Density Functional Theory Calculations ◽  
Radical Cyclizations ◽  
Computational Studies ◽  
Fungal Metabolite ◽  
Acyl Radical ◽  
Functional Theory ◽  
Formal Synthesis ◽  
Acyl Radicals ◽  
Insight Into

An investigation into the cyclization of acyl radicals with mono- and disubstituted β-alkoxyacrylates is described. Ether-tethered acyl radicals, generated directly from the corresponding aldehyde, undergo cyclization to form dioxaspiro heterocyclic systems including 1,7-dioxaspiro[4,4]nonane-4,8-dione and 1,8-dioxaspiro[5,4]decane-5,9-dione. This strategy is applied to a concise formal synthesis of the fungal metabolite longianone. Density functional theory calculations provide insight into the chemistry of the acyl radicals in this study.

ChemInform Abstract: Model Studies of Palladium-Catalyzed Coupling Reactions for the “South- North” Attachment of Avermectins.

ChemInform ◽  
2010 ◽  
Vol 22 (20) ◽  
pp. no-no
Author(s):  
J. P. FEREZOU ◽  
M. JULIA ◽  
Y. LI ◽  
W. LIU ◽  
A. PANCRAZI
Keyword(s):  
Coupling Reactions ◽  
Abstract Model ◽  
The South ◽  
Model Studies ◽  
Palladium Catalyzed
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