ChemInform Abstract: A New Stereoselective Synthesis of Chiral Optically Pure 4-Piperidones.

ChemInform ◽  
2010 ◽  
Vol 26 (52) ◽  
pp. no-no
Author(s):  
I. RIPOCHE ◽  
J. GELAS ◽  
D. GREE ◽  
R. GREE ◽  
Y. TROIN
Keyword(s):  
Stereoselective Synthesis ◽  
Optically Pure

Highly Stereoselective Synthesis of Optically Pure C-Aryl Imines from α-L-Amino Acid Methyl Esters.

ChemInform ◽  
2004 ◽  
Vol 35 (17) ◽  
Author(s):  
Antonella Leggio ◽  
Adolfo Le Pera ◽  
Angelo Liguori ◽  
Anna Napoli ◽  
Claudio Romeo ◽  
...  
Keyword(s):  
Amino Acid ◽  
Stereoselective Synthesis ◽  
Methyl Esters ◽  
Acid Methyl ◽  
Optically Pure ◽  
Amino Acid Methyl Esters

Stereoselective Synthesis of the Optically Pure AB-Ring Moiety of Trichothecene Sesquiterpene (+)-Calonectrin

Heterocycles ◽  
2003 ◽  
Vol 59 (2) ◽  
pp. 595 ◽  
Author(s):  
Kiyoshi Tomioka ◽  
Akira Iida ◽  
Kazuhide Konishi ◽  
Hironobu Matsumoto ◽  
Masafumi Kaneko
Keyword(s):  
Stereoselective Synthesis ◽  
Optically Pure ◽  
Ab Ring

Stereoselective Synthesis of Optically Pure 2-Amino-2′-hydroxy-1,1′-binaphthyls

2018 ◽  
Vol 20 (8) ◽  
pp. 2459-2463 ◽  
Author(s):  
Hagit Forkosh ◽  
Vlada Vershinin ◽  
Hagai Reiss ◽  
Doron Pappo
Keyword(s):  
Stereoselective Synthesis ◽  
Optically Pure

scholarly journals Stereoselective synthesis of substituted 2,5-diazabicyclo[2.2.1]heptanes by iodine-mediated cyclization of optically pure compounds containing the 4,5-diamino-1,7-octadiene and 1,2-diamino-4-alkene moieties

Tetrahedron ◽  
2007 ◽  
Vol 63 (50) ◽  
pp. 12446-12453 ◽  
Author(s):  
Giuseppe Alvaro ◽  
Romano Di Fabio ◽  
Andrea Gualandi ◽  
Claudio Fiorelli ◽  
Magda Monari ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Pure Compounds ◽  
Optically Pure

scholarly journals InCI3-catalyzed stereoselective synthesis of optically pure 1,5-benzodiazepines

ARKIVOC ◽  
2005 ◽  
Vol 2005 (3) ◽  
pp. 221-227 ◽  
Author(s):  
J.S. Yadav ◽  
B.V.S. Reddy ◽  
G. Satheesh G. Srinivasulu ◽  
A. C. Kunwar
Keyword(s):  
Stereoselective Synthesis ◽  
Optically Pure

Enantioselective ring opening of tropinone. A new entry into tropane alkaloids

1997 ◽  
Vol 75 (6) ◽  
pp. 754-761 ◽  
Author(s):  
Marek Majewski ◽  
Ryszard Lazny ◽  
Agnieszka Ulaczyk
Keyword(s):  
Ring Opening ◽  
Stereoselective Synthesis ◽  
Tropane Alkaloids ◽  
Amine Hydrochloride ◽  
Lithium Amides ◽  
Ring Opening Reaction ◽  
Alkyl Chloroformates ◽  
Optically Pure ◽  
Enantioselective Deprotonation

The lithium enolate of tropinone reacts with alkyl chloroformates to give 6-N-carboalkoxy-N-methyl-2-cycloheptenones (4). These compounds can be produced enantioselectively, in up to 95% ee, if chiral lithium amides (derived from optically pure amines 5–7) are used for deprotonation of tropinone in the presence of additives. The effect of additives such as LiCl, LiBr, LiF, LiClO4, CeCl3, ZnCl2, LiOH, TMEDA, HMPA, and DMPU on enantioselectivity of this deprotonation–ring opening sequence varies from slight to very large depending on the chiral amide – additive combination. Especially large increases in enantioselectivity are observed when the chiral, C2 symmetrical, lithium bis-α,α′-methylbenzylamide (Li-5a) is used with one equivalent of LiCl. This reagent is best generated in situ from the corresponding amine hydrochloride and n-BuLi (2 equiv.). The ring-opening reaction combined with transposition of the carbonyl group (via Wharton reaction or allylic oxidation) provides a new method of stereoselective synthesis of tropane alkaloids having a protected hydroxyl at C-6 or C-7 (6β- and 7β-acetoxytropanes 14a, b) and physoperuvine (19). Keywords: enantioselective deprotonation, tropane alkaloids.

Stereoselective synthesis of optically pure γ-fluoro-β-enaminosulfoxides and reduction to γ-fluoro-β-aminosulfoxides

1995 ◽  
Vol 36 (17) ◽  
pp. 3043-3046 ◽  
Author(s):  
Pierfrancesco Bravo ◽  
Marcello Crucianelli ◽  
Matteo Zanda
Keyword(s):  
Stereoselective Synthesis ◽  
Optically Pure
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