ChemInform Abstract: New Developments in Synthetic Methods for the Preparation of Fluoro- Containing Heterocyclic Compounds

ChemInform ◽  
2010 ◽  
Vol 26 (46) ◽  
pp. no-no
Author(s):  
G. G. FURIN
Keyword(s):  
Heterocyclic Compounds ◽  
Synthetic Methods ◽  
New Developments

scholarly journals General sociolinguistics, social semiotics and semiotics of culture – ex pluribus unum? Forty years after Language as Social Semiotic

2020 ◽  
Vol 47 (3/4) ◽  
Author(s):  
Suren Zolyan
Keyword(s):  
Social Sciences ◽  
Goal Setting ◽  
Synthetic Methods ◽  
Social Semiotics ◽  
Dynamic Approach ◽  
Functional Characteristics ◽  
New Developments ◽  
Meaning Production ◽  
Linguistic Structures

The birth of social semiotics is usually associated with the publication of Michael Halliday’s book Language as Social Semiotic (1978). We try to draw attention to possible new developments in social semiotics, which still remain a potential transdisciplinary project for social sciences. In order to do this, we address the interrelation between sociolinguistics, social semiotics and the semiotics of culture. All of these describe mechanisms of meaning production and translation beyond linguistic structures. The differentiation between these workings is based on a distinc tion between various aspects of meaning production and communication and functional characteristics of goal setting. The complexity of these processes legitimates the complexity of methodology used to describe them. Interconnection between different domains and aspects may create synthetic methods based on the dynamic approach to meaning production and transmission.

scholarly journals Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent

2021 ◽  
Vol 12 (3) ◽  
pp. 279-283
Author(s):  
Gautam Sadawarte ◽  
Samadhan Jagatap ◽  
Mukesh Patil ◽  
Vasant Jagrut ◽  
Jamatsing Darbarsing Rajput
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Research Work ◽  
Synthetic Methods ◽  
Alpha Amylase ◽  
Spectroscopic Techniques ◽  
Inhibition Activity ◽  
Antidiabetic Agent ◽  
Biological Functions ◽  
Ir Spectroscopic

This research work describes the synthesis of a new series of heterocyclic compounds, namely sulfonamide derivatives. Sulfonamides are a diverse class of organic compounds having significant and potent biological activities. Diverse synthetic methods have been engaged to build up its various derivatives for different biological functions. In this study, the production of novel pyridine-based heterocyclic compounds having sulfonamide moieties has been elaborated. The obtained sulfonamide-based pyridine scaffold was used to investigate their alpha-amylase inhibition activity. The structures of freshly prepared compounds were described using 1H NMR, 13C NMR, and IR spectroscopic techniques. The molecular docking of sulfonamides performed against porcine pancreatic alpha-amylase using PDB file 1LP was used for generation of grid. All the new synthesized compounds were shown notable anti-diabetic activity.

Recent Progress in Chemistry of β-Lactams

2019 ◽  
Vol 16 (6) ◽  
pp. 544-567 ◽  
Author(s):  
Japheth O. Ombito ◽  
Girija S. Singh
Keyword(s):  
Heterocyclic Compounds ◽  
Bond Cleavage ◽  
Biological Significance ◽  
Synthetic Methods ◽  
Biologically Relevant ◽  
Amino Esters ◽  
Ring Expansions ◽  
Amide Carbonyl ◽  
Amide Carbonyl Group ◽  
Lactam Ring

The β-lactams constitute a well-known class of compounds having tremendous biological significance. Besides being a motif of biological interest, they serve as versatile synthons in organic chemistry. In fact, their easy accessibility in the laboratory by several methods combined with inherent reactivity of the β -lactam ring due to ring-strain places it among the most sought for substrate in the arsenal of synthetic organic chemists. Several chemical reagents, heat, and light promote its ring-opening, ring-expansions and rearrangement reactions yielding a wide variety of biologically relevant nitrogen-containing acyclic and heterocyclic compounds. In recent years, the reactivity of differently functionalized β-lactam rings towards diverse kinds of reagents has been investigated. These investigations exploit selective bond cleavage of the β-lactam nucleus via N1-C2, C3- C4, C2-C3 or N1-C4 bond cleavage using simple reagents. The reduction of amide carbonyl group, thionation, and pyrolysis/photolysis have also been explored. These investigations have led to the discovery of many easy synthetic methods for biologically important classes of compounds such as β-amino acids, β-amino esters, amino sugars, amino alcohols, peptides, azetidines, and other heterocyclic compounds. This article discusses the advances made in the studies on the reactivity of β- lactam ring during the last ten years.

scholarly journals Biomimetic molecular design tools that learn, evolve, and adapt

2017 ◽  
Vol 13 ◽  
pp. 1288-1302 ◽  
Author(s):  
David A Winkler
Keyword(s):  
Molecular Design ◽  
Optimization Methods ◽  
Synthetic Methods ◽  
Biological Processes ◽  
New Developments ◽  
Design And Optimization ◽  
Bioactive Natural Products ◽  
Unit Operations ◽  
S Curve ◽  
Pass Through

A dominant hallmark of living systems is their ability to adapt to changes in the environment by learning and evolving. Nature does this so superbly that intensive research efforts are now attempting to mimic biological processes. Initially this biomimicry involved developing synthetic methods to generate complex bioactive natural products. Recent work is attempting to understand how molecular machines operate so their principles can be copied, and learning how to employ biomimetic evolution and learning methods to solve complex problems in science, medicine and engineering. Automation, robotics, artificial intelligence, and evolutionary algorithms are now converging to generate what might broadly be called in silico-based adaptive evolution of materials. These methods are being applied to organic chemistry to systematize reactions, create synthesis robots to carry out unit operations, and to devise closed loop flow self-optimizing chemical synthesis systems. Most scientific innovations and technologies pass through the well-known “S curve”, with slow beginning, an almost exponential growth in capability, and a stable applications period. Adaptive, evolving, machine learning-based molecular design and optimization methods are approaching the period of very rapid growth and their impact is already being described as potentially disruptive. This paper describes new developments in biomimetic adaptive, evolving, learning computational molecular design methods and their potential impacts in chemistry, engineering, and medicine.

scholarly journals A Review of the Pharmacological Activities and Recent Synthetic Advances of γ-Butyrolactones

2021 ◽  
Vol 22 (5) ◽  
pp. 2769
Author(s):  
Joonseong Hur ◽  
Jaebong Jang ◽  
Jaehoon Sim
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Small Molecules ◽  
Biologically Active ◽  
Synthetic Methods ◽  
Pharmacological Activities ◽  
New Developments ◽  
The Past ◽  
Privileged Structures ◽  
Significant Attention

γ-Butyrolactone, a five-membered lactone moiety, is one of the privileged structures of diverse natural products and biologically active small molecules. Because of their broad spectrum of biological and pharmacological activities, synthetic methods for γ-butyrolactones have received significant attention from synthetic and medicinal chemists for decades. Recently, new developments and improvements in traditional methods have been reported by considering synthetic efficiency, feasibility, and green chemistry. In this review, the pharmacological activities of natural and synthetic γ-butyrolactones are described, including their structures and bioassay methods. Mainly, we summarize recent advances, occurring during the past decade, in the construction of γ-butyrolactone classified based on the bond formation in γ-butyrolactone between (i) C5-O1 bond, (ii) C4-C5 and C2-O1 bonds, (iii) C3-C4 and C2-O1 bonds, (iv) C3-C4 and C5-O1 bonds, (v) C2-C3 and C2-O1 bonds, (vi) C3-C4 bond, and (vii) C2-O1 bond. In addition, the application to the total synthesis of natural products bearing γ-butyrolactone scaffolds is described.

scholarly journals 1,6-Naphthyridin-2(1H)-ones: Synthesis and Biomedical Applications

2021 ◽  
Vol 14 (10) ◽  
pp. 1029
Author(s):  
Juan Marcos Oliveras ◽  
Raimon Puig de la Bellacasa ◽  
Roger Estrada-Tejedor ◽  
Jordi Teixidó ◽  
José I. Borrell
Keyword(s):  
Double Bond ◽  
Heterocyclic Compounds ◽  
Biomedical Applications ◽  
The Body ◽  
Synthetic Methods

Naphthyridines, also known as diazanaphthalenes, are a group of heterocyclic compounds that include six isomeric bicyclic systems containing two pyridine rings. 1,6-Naphthyridines are one of the members of such a family capable of providing ligands for several receptors in the body. Among such structures, 1,6-naphthyridin-2(1H)-ones (7) are a subfamily that includes more than 17,000 compounds (with a single or double bond between C3 and C4) included in more than 1000 references (most of them patents). This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, C7, and C8 of 1,6-naphthyridin-2(1H)-ones, the synthetic methods used for their synthesis (both starting from a preformed pyridine or pyridone ring), and the biomedical applications of such compounds.

Synthetic Methods and Pharmacological Potential of Different Oxazine Analogs

2021 ◽  
Vol 18 ◽  
Author(s):  
Mohammad Asif ◽  
Mohd. Imran
Keyword(s):  
Organic Chemistry ◽  
Drug Resistance ◽  
Sodium Hydroxide ◽  
Crucial Role ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Synthetic Methods ◽  
Wide Range ◽  
Different Types ◽  
Pharmacological Potential

: Oxazine analog is a vital class of heterocyclic compounds and has attracted synthetic interest owing to their wide range of biological activities. Oxazine analogs are valuable in medicinal organic chemistry and exhibited different varieties of biological activities such as antimicrobial, anticancer, antimalarial, antitubercular, sedative, anticonvulsant, analgesic, anti-inflammatory, antipyretic, etc. Oxazine can be derived from benzene by appropriate substitution of carbon atoms of the ring by nitrogen and oxygen atoms. Nowadays, the development of drug resistance is a key problem, and to defeat this problem, it is crucial to synthesize novel compounds. So novel oxazine analogs may play a crucial role to overcome these problems. Oxazine analogs are prepared by reaction of chalcone derivatives with thiourea in the presence of alcohol and sodium hydroxide. The present aims of this review to give an outline of some different synthetic methods and different types of biological activities of oxazine analogs. We hope that this review will be motivating for researchers concerned with oxazine analogs.

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