ChemInform Abstract: ipso-Substitution on an Acyl Group in Reactions of 3-Acyl-Substituted Ethyl 7,8-Difluoro-5-oxo-5,9a-dihydropyrazolo(1,5-a)quinoline-4- carboxylates (I), (III) with Electrophilic Reagents.

ChemInform ◽  
2010 ◽  
Vol 25 (33) ◽  
pp. no-no
Author(s):  
YU. A. AZEV ◽  
S. V. SHORSHNEV ◽  
S. G. ALEXEEV ◽  
V. N. CHARUSHIN ◽  
O. N. CHUPAKHIN
Keyword(s):  
Ipso Substitution ◽  
Electrophilic Reagents

ipso-Substitution of an Acyl group in Reactions of 3-Acyl-substituted Ethyl 7,8-Difluoro-5-oxo-5,9a-dihydropyrazolo[1,5-a]quinoline-4-carboxylates with Electrophilic Reagents

1993 ◽  
Vol 3 (3) ◽  
pp. 99-100 ◽  
Author(s):  
Yurii A. Azev ◽  
Sergei V. Shorshnev ◽  
Sergei G. Alexeev ◽  
Valerii N. Charushin ◽  
Oleg N. Chupakhin
Keyword(s):  
Ipso Substitution ◽  
Electrophilic Reagents

Research Progress on Cross-coupling Reactions of Alkenylaluminum with Electrophilic Reagents

2018 ◽  
Vol 22 (15) ◽  
pp. 1523-1535 ◽  
Author(s):  
Qing Han Li ◽  
Xue Bei Shao ◽  
Yong Ding ◽  
Chang Wen ◽  
Zhi Gang Zhao
Keyword(s):  
Cross Coupling ◽  
Research Progress ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Electrophilic Reagents

ChemInform Abstract: RADICAL ALKYLDENITRATION. A SYNTHETICALLY USEFUL EXAMPLE OF HOMOLYTIC AROMATIC IPSO-SUBSTITUTION REACTIONS

1978 ◽  
Vol 9 (24) ◽  
Author(s):  
L. TESTAFERRI ◽  
M. TIECCO ◽  
M. TINGOLI ◽  
M. FIORENTINO ◽  
L. TROISI
Keyword(s):  
Substitution Reactions ◽  
Ipso Substitution

scholarly journals Catalytic Antioxidant Activity of Bis-Aniline-Derived Diselenides as GPx Mimics

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4446
Author(s):  
Giancarlo V. Botteselle ◽  
Welman C. Elias ◽  
Luana Bettanin ◽  
Rômulo F. S. Canto ◽  
Drielly N. O. Salin ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Hydrogen Bond ◽  
Electronic Properties ◽  
Partial Charge ◽  
Amino Group ◽  
Diphenyl Diselenide ◽  
Charge Delocalization ◽  
Ipso Substitution ◽  
Efficient Route ◽  
Catalytic Performances

Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides were obtained in good yields via ipso-substitution/reduction from the readily available 2-nitroaromatic halides (Cl, Br, I). These diselenides present GPx-mimetic properties, showing better antioxidant activity than the standard GPx-mimetic compounds, ebselen and diphenyl diselenide. DFT analysis demonstrated that the electronic properties of the substituents determine the charge delocalization and the partial charge on selenium, which correlate with the catalytic performances. The amino group concurs in the stabilization of the selenolate intermediate through a hydrogen bond with the selenium.

scholarly journals Ruthenium Catalyzed β-Selective Alkylation of Vinylpyridines with Aldehydes/Ketones via N2H4 Mediated Deoxygenative Couplings

2021 ◽  
Author(s):  
Leiyang Lv ◽  
Chao-Jun Li
Keyword(s):  
Polarity Reversal ◽  
Electrophilic Reagents ◽  
Selective Alkylation

Umpolung (polarity reversal) tactics of aldehydes/ketones have greatly broadened the carbonyl chemistry by enabling transformations with electrophilic reagents and deoxygenative functionalizations. Herein, we reported the first ruthenium-catalyzed β-selective alkylation of...

ChemInform Abstract: REACTIONS OF 2,4,6-TRIARYLDIHYDRO-1,3,5-DITHIAZINES WITH ELECTROPHILIC REAGENTS

1984 ◽  
Vol 15 (20) ◽  
Author(s):  
Y. TAKIKAWA ◽  
K. SHIMADA ◽  
T. MAKABE ◽  
S. TAKIZAWA
Keyword(s):  
Electrophilic Reagents

Ketalised 3,4-dihydroxybutyllithiums: New intermediates to transfer four-carbon diol functionality to electrophilic reagents

Tetrahedron ◽  
1996 ◽  
Vol 52 (24) ◽  
pp. 8333-8340 ◽  
Author(s):  
Fernando F. Huerta ◽  
Cecilia Gómez ◽  
Miguel Yus
Keyword(s):  
Electrophilic Reagents

Synthesis of Fullerols as Polyhydroxylated Fullerene Derivatives

1992 ◽  
Vol 247 ◽  
Author(s):  
Long Y. Chiang ◽  
Ravi Upasani ◽  
John W. Swirczewski ◽  
Kathy Creegan
Keyword(s):  
Structural Components ◽  
Synthetic Methodology ◽  
Fullerene Derivatives ◽  
Aqueous Acid ◽  
Epoxidation Reaction ◽  
Electrophilic Reagents

ABSTRACTwe outline three methods for the preparation of fullerols as polyhydroxylated fullerene derivatives through the reaction of fullerenes with electrophilic reagents. The synthetic methodology includes a sequence of reactions using an aqueous acid chemistry, the epoxidation reaction, or the interesting nitronium chemistry as an key approach for the conversion of fullerenes to fullerols. The structure of fullerols was characterized and proposed to consist of at least 13 hydroxy functional moieties incorporating both hydroxy and hemi-ketal as parts of the structural components.

scholarly journals Synthesis and antimicrobial activities of novel n-substituted 8-(1-alkyl/alkylsulphonyl/alkoxycarbonyl-benzimidazol-2-ylmethoxy)-5-chloroquinolines

2011 ◽  
Vol 76 (9) ◽  
pp. 1199-1206 ◽  
Author(s):  
Raju Chaudhari ◽  
Sahebrao Rindhe
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Nitrogen Heterocycles ◽  
Antimicrobial Activities ◽  
Mass Spectral Data ◽  
Antifungal Activities ◽  
Mass Spectral ◽  
Electrophilic Reagents ◽  
Almost All ◽  
And Staphylococcus Aureus

Herein the synthesis of a series of novel 8-(1- alkyl/alkylsulphonyl/alkoxycarbonyl-benzimidazol-2-ylmethoxy)-5- chloroquinoline derivatives is reported. These derivatives were prepared by the condensation of o-phenylenediamine with [(5-chloroquinolin-8- yl)oxy]acetic acid, followed by substitution at nitrogen with different electrophilic reagents in presence of an appropriate base to give a series of nitrogen heterocycles containing the benzimidazole and quinoline nuclei. The structures of the compounds were confirmed based on 1H-NMR, 13CNMR, IR and mass spectral data. Almost all the compounds exhibited promising antibacterial activity against Salmonella typhimurium and Staphylococcus aureus. Some of the compounds showed good antifungal activities against Aspergillus niger but the antifungal activities against Candida albicans were disappointing.

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