1,2,4-Triazine Chemistry Part IV: Synthesis and Chemical Behavior of 3-Functionalized 5,6-Diphenyl-1,2,4-triazines towards Some Nucleophilic and Electrophilic Reagents

2014 ◽  
Vol 52 (6) ◽  
pp. 1595-1607 ◽  
Author(s):  
Reda M. Abdel-Rahman ◽  
Mohamed S. T. Makki ◽  
Tarik E. Ali ◽  
Magdy A. Ibrahim
Keyword(s):  
Chemical Behavior ◽  
Electrophilic Reagents

Research Progress on Cross-coupling Reactions of Alkenylaluminum with Electrophilic Reagents

2018 ◽  
Vol 22 (15) ◽  
pp. 1523-1535 ◽  
Author(s):  
Qing Han Li ◽  
Xue Bei Shao ◽  
Yong Ding ◽  
Chang Wen ◽  
Zhi Gang Zhao
Keyword(s):  
Cross Coupling ◽  
Research Progress ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Electrophilic Reagents

Bio-organometallic Peptide Conjugates: Recent Advances in Their Synthesis and Prospects for Biomedical Application

2020 ◽  
Vol 24 (21) ◽  
pp. 2508-2523
Author(s):  
Johana Gómez ◽  
Diego Sierra ◽  
Constanza Cárdenas ◽  
Fanny Guzmán
Keyword(s):  
Amino Acids ◽  
Biomedical Application ◽  
Structural Diversity ◽  
Biological Properties ◽  
Therapeutic Agents ◽  
Organometallic Complexes ◽  
Chemical Behavior ◽  
Metal Compounds ◽  
Bioorganometallic Chemistry ◽  
Pharmacological Control

One area of organometallic chemistry that has attracted great interest in recent years is the syntheses, characterization and study of organometallic complexes conjugated to biomolecules with different steric and electronic properties as potential therapeutic agents against cancer and malaria, as antibiotics and as radiopharmaceuticals. This minireview focuses on the unique structural diversity that has recently been discovered in α- amino acids and the reactions of metallocene complexes with peptides having different chemical behavior and potential medical applications. Replacing α-amino acids with metallocene fragments is an effective way of selectively influencing the physicochemical, structural, electrochemical and biological properties of the peptides. Consequently, research in the field of bioorganometallic chemistry offers the opportunity to develop bioactive metal compounds as an innovative and promising approach in the search for pharmacological control of different diseases.

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