ChemInform Abstract: Magnesium Iodide-Diethyl Ether-Acetic Anhydride: A New and Efficient Acylating System for Primary, Secondary and Tertiary Alcohols and Phenols.

ChemInform ◽  
2010 ◽  
Vol 24 (50) ◽  
pp. no-no
Author(s):  
P. K. CHOWDHURY
Keyword(s):  
Acetic Anhydride ◽  
Diethyl Ether ◽  
Tertiary Alcohols

Formation of iodides and esters from alcohols and tributyldiiodophosphorane and diiodotriphenylphosphorane

1982 ◽  
Vol 35 (3) ◽  
pp. 517 ◽  
Author(s):  
RK Haynes ◽  
M Holden
Keyword(s):  
Diethyl Ether ◽  
Room Temperature ◽  
Temperature Treatment ◽  
Butyl Alcohol ◽  
Secondary Alcohols ◽  
Benzoic Acids ◽  
Lithium Iodide ◽  
Hexamethylphosphoric Triamide ◽  
Tertiary Alcohols

Tributyldiiodophosphorane and diiodotriphenylphosphorane, prepared in situ from the corresponding phosphine and iodine, are generally able to convert primary and secondary alcohols into iodides at room temperature in diethyl ether or benzene containing two equivalents of hexamethylphosphoric triamide. Tertiary alcohols, as gauged by the lack of reactivity of t-butyl alcohol, are, however, inert to these iodinating agents. 6-Hydroxyhexanoic acid yields a mixture of 6-iodohexanoic acid and 7-heptanolide. The first reagent also promotes facile condensation of secondary and tertiary alcohols with carboxylic acids to form hindered esters in good yields. The phosphorane derived from tris-(dimethy1amino)phosphine and iodine, while less effective as an iodinating agent, rapidly converts 6-hydroxyhexanoic acid into 6-iodo-N,N-dimethylhexanamide, and hexanoic and benzoic acids into the corresponding N,N-dimethylamides in excellent yields at room temperature. Treatment of 3β- tosyloxycholest-5-ene with lithium iodide yields 3β-iodocholest-5-ene, and not 3α-iodocholest-5-ene, as previously reported.

Methylthiomethyl ethers: Their use in the protection and methylation of hydroxyl groups

1978 ◽  
Vol 31 (5) ◽  
pp. 1031 ◽  
Author(s):  
PM Pojer ◽  
SJ Angyal
Keyword(s):  
Acetic Acid ◽  
Acetic Anhydride ◽  
Dimethyl Sulfoxide ◽  
Methyl Iodide ◽  
Good Yield ◽  
Hydroxyl Groups ◽  
Nickel Boride ◽  
Tertiary Alcohols ◽  
Methylthiomethyl Ethers

Methylthiomethyl ethers are obtained in good yield from primary, secondary and tertiary alcohols by treating them with a mixture of dimethyl sulfoxide, acetic anhydride and acetic acid. The methyl- thiomethyl groups are readily removed on heating the compounds with methyl iodide in moist acetone. The methylthiomethyl ethers are converted into methyl ethers by the action of 'nickel boride'.

RADIOIMMUNOASSAY OF OESTRONE AND OESTRADIOL IN THE PERIPHERAL PLASMA OF THE DOMESTIC FOWL IN VARIOUS PHYSIOLOGICAL STATES AND OF HYPOPHYSECTOMIZED AND OVARIECTOMIZED FOWLS

1974 ◽  
Vol 75 (1) ◽  
pp. 133-140 ◽  
Author(s):  
B. E. Senior
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Diethyl Ether ◽  
Bovine Serum ◽  
Domestic Fowl ◽  
Laying Hens ◽  
Peripheral Plasma ◽  
The Mean ◽  
Precision And Accuracy ◽  
Chicken Ovary

ABSTRACT A radioimmunoassay was developed to measure the levels of oestrone and oestradiol in 0.5–1.0 ml of domestic fowl peripheral plasma. The oestrogens were extracted with diethyl ether, chromatographed on columns of Sephadex LH-20 and assayed with an antiserum prepared against oestradiol-17β-succinyl-bovine serum albumin using a 17 h incubation at 4°C. The specificity, sensitivity, precision and accuracy of the assays were satisfactory. Oestrogen concentrations were determined in the plasma of birds in various reproductive states. In laying hens the ranges of oestrone and oestradiol were 12–190 pg/ml and 29–327 pg/ml respectively. Levels in immature birds, in adult cockerels and in an ovariectomized hen were barely detectable. The mean concentrations of oestrone and oestradiol in the plasma of four non-laying hens (55 pg/ml and 72 pg/ml respectively) and one partially ovariectomized hen (71 pg/ml and 134 pg/ml respectively) were well within the range for laying hens. It is evident that the large, yolk-filled follicles are not the only source of oestrogens in the chicken ovary.

DETERMINATION OF ALDOSTERONE AND DEOXYCORTICOSTERONE IN PLASMA USING 3H-ACETIC ANHYDRIDE AND VAPOUR PHASE ACETYLATION

1969 ◽  
Vol 61 (1_Suppl) ◽  
pp. S12 ◽  
Author(s):  
V. H. T. James ◽  
A. E. Rippon ◽  
M. L. Arnold
Keyword(s):  
Acetic Anhydride ◽  
Vapour Phase
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