ChemInform Abstract: Synthesis of Met- and Leu-Enkephalin Analogues Containing Chiral N,N′- Ethylene-Bridged Phenylalanyl-Methionine and -Leucine

ChemInform ◽  
2010 ◽  
Vol 24 (34) ◽  
pp. no-no
Author(s):  
H. TAKENAKA ◽  
H. MIYAKE ◽  
Y. KOJIMA ◽  
M. YASUDA ◽  
M. GEMBA ◽  
...  
Keyword(s):  
Enkephalin Analogues

Synthesis and biological activity of branched enkephalin analogues containing two amino acids in a side chain

1998 ◽  
Vol 33 (4) ◽  
pp. 331-334 ◽  
Author(s):  
Irina Bobrova ◽  
Natalia Mishlakova ◽  
Anette Selander ◽  
Elena Mekshun ◽  
Guntis Rozental
Keyword(s):  
Amino Acids ◽  
Biological Activity ◽  
Side Chain ◽  
Enkephalin Analogues

New Dimeric Tetrapeptide Enkephalin Analogues with Fiveor Six-Carbon Hydrophilic Spacers

1995 ◽  
Vol 50 (9) ◽  
pp. 1329-1334 ◽  
Author(s):  
I. Zajączkowski ◽  
J. Stępiński ◽  
A. Temeriusz ◽  
S. W. Tam
Keyword(s):  
Opioid Peptide ◽  
Enkephalin Analogues ◽  
Kappa Receptors ◽  
Kappa Receptor ◽  
Delta Receptors

AbstractTo investigate the role of distance between two opioid peptide pharmacophores on binding activities to delta, mu and kappa receptor in vitro, a number of new dimeric enkephalin analogues were synthesized in which two identical tetrapeptides: Tyr-D-Ala-Gly-Phe were connected together at their C-termini by α,ω-diamino-α,ω-dideoxyalditols. The length of the hydrophilic spacer (3 -6 carbons) did not affect the affinities for delta receptors, whereas the affinities for mu and kappa receptors were dependent on the length as well as the configuration of the spacer. The analogues had high affinities, and some of them possessed moderate delta selectivity.

scholarly journals Amino acids and peptides. X. Leu-enkephalin analogues containing a fluorinated aromatic amino acid.

1989 ◽  
Vol 37 (3) ◽  
pp. 826-828 ◽  
Author(s):  
Mitsuko MAEDA ◽  
Koichi KAWASAKI ◽  
Joe WATANABE ◽  
Hiroshi KANETO
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Enkephalin Analogues

[Cys(O2NH2)2]enkephalin analogues and dalargin: Selectivity for δ-opioid receptors

1996 ◽  
Vol 304 (1-3) ◽  
pp. 99-108 ◽  
Author(s):  
Nevena Pencheva ◽  
Adriana Bocheva ◽  
Emil Dimitrov ◽  
Christina Ivancheva ◽  
Radomir Radomirov
Keyword(s):  
Opioid Receptors ◽  
Enkephalin Analogues

Novel Design of Bicyclic β-Turn Dipeptides on Solid-Phase Supports and Synthesis of [3.3.0]-Bicyclo[2,3]-Leu-enkephalin Analogues

2004 ◽  
Vol 6 (19) ◽  
pp. 3285-3288 ◽  
Author(s):  
Xuyuan Gu ◽  
Jinfa Ying ◽  
Richard S. Agnes ◽  
Edita Navratilova ◽  
Peg Davis ◽  
...  
Keyword(s):  
Solid Phase ◽  
Enkephalin Analogues ◽  
Novel Design

Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted β-turn bicyclic dipeptide mimetics

2003 ◽  
pp. 1598-1599 ◽  
Author(s):  
Chiyi Xiong ◽  
Junyi Zhang ◽  
Peg Davis ◽  
Wei Wang ◽  
Jinfa Ying ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Enkephalin Analogues
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